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6 T Cell Responses in Fungal Infections

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Human Fungal Pathogens

Part of the book series: The Mycota ((MYCOTA,volume 12))

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Abstract

Fungal diseases represent an important immunological paradigm because they can result from either defective immune recognition or overreacting inflammatory responses. The ever-growing number of patients suffering from life-threatening fungal diseases as a consequence of advances in medical care has created a pressing need to clarify both the molecular and cellular bases of fungal virulence as well as the mechanisms of host and fungal adaptation underlying immune homeostasis. Understanding the dynamics of the host–fungus interaction is central to the design of novel antifungal therapies and provides the foundation for successful vaccination strategies. This chapter reviews recent advances in the knowledge of adaptive immunity to fungi, positioning them within the conceptual framework of resistance-based versus tolerance-based antifungal responses, and how these mechanisms can be exploited for improved management of severe fungal infections and diseases.

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Acknowledgments

We thank Cristina Massi-Benedetti for editorial assistance. The authors’ work was supported by the ERC Advanced Grant FUNMETA (ERC-2011-AdG-293714). Cristina Cunha was supported by the Fundação para a Ciência e Tecnologia, Portugal (contract SFRH/BD/65962/2009). We sincerely apologize to all those colleagues whose important work is not cited because of space considerations.

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  1. Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Polo Unico Sant’Andrea delle Fratte, 06132, Perugia, Italy

    Cristina Cunha, Luigina Romani & Agostinho Carvalho

  2. Department of Clinical and Experimental Medicine, University of Parma, via Gramsci 14, 43126, Parma, Italy

    Franco Aversa

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  1. Cristina Cunha
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  2. Franco Aversa
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  3. Luigina Romani
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  4. Agostinho Carvalho
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Correspondence to Agostinho Carvalho .

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  1. Friedrich Schiller University of Jena, Jena, Germany

    Oliver Kurzai

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Cunha, C., Aversa, F., Romani, L., Carvalho, A. (2014). 6 T Cell Responses in Fungal Infections. In: Kurzai, O. (eds) Human Fungal Pathogens. The Mycota, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39432-4_6

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