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1 From Commensal to Pathogen: Candida albicans

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Book cover Human Fungal Pathogens

Part of the book series: The Mycota ((MYCOTA,volume 12))

Abstract

The attributes that allow Candida albicans to be a successful human commensal overlap with its ability to cause opportunistic disease. The ways in which C. albicans successfully transitions from a commensal to a pathogen involve many aspects of its growth and interaction with the host, including the host recognition of and response to the various cell types that characterise this fungal species. We discuss the factors that are important for commensal growth, stress responses, the role of the cell wall in immune recognition, attachment to and interactions with epithelial cells, and interactions with immune cells as key aspects of the commensal–pathogenic life style of this fungus.

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Acknowledgements

NG and AW were supported by the Wellcome Trust (080088, 086827, 075470 & 097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338). BH is supported by the Federal Ministry of Education and Research (BMBF: ERA Net PathoGenoMics CandiCol 0315901B), the Center for Sepsis Control and Care (CSCC – BMBF 01EO1002), the Deutsche Forschungsgemeinschaft (DFG Hu 528/15, 16 and 17), the Jena School for Microbial Communication (JSMC), and the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS).

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  1. School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK

    Amy Whittington & Neil A. R. Gow

  2. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute Jena (HKI), Friedrich Schiller University, Center for Sepsis Control and Care, Beutenbergstrasse 11a, 07745, Jena, Germany

    Bernhard Hube

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  1. Amy Whittington
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  2. Neil A. R. Gow
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  3. Bernhard Hube
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Correspondence to Neil A. R. Gow .

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  1. Friedrich Schiller University of Jena, Jena, Germany

    Oliver Kurzai

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Whittington, A., Gow, N.A.R., Hube, B. (2014). 1 From Commensal to Pathogen: Candida albicans . In: Kurzai, O. (eds) Human Fungal Pathogens. The Mycota, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39432-4_1

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