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Insights into Structural Basis of Mammalian Mitochondrial Translation

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Translation in Mitochondria and Other Organelles

Abstract

Mitochondrial ribosomes are known to be quite divergent from cytoplasmic ribosomes in both composition and structure even as their main functional cores, such as the mRNA decoding and peptidyl transferase sites, are highly conserved. The translational factors that interact with these ribosomes to facilitate the process of protein synthesis in mitochondria have also likewise acquired unique structural features, apparently to complement the structure and function of the mitochondrial ribosome. In this chapter, we describe the current state of structural knowledge of the mammalian mitochondrial ribosome, some of its component proteins, and key translational factors.

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Acknowledgments

This work was supported by the National Institutes of Health grant R01 GM61576 (to R.K.A.).

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Authors and Affiliations

  1. Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA

    Manjuli R. Sharma, Prem S. Kaushal, Mona Gupta & Rajendra K. Agrawal

  2. Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA

    Nilesh K. Banavali

  3. Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA

    Nilesh K. Banavali & Rajendra K. Agrawal

Authors
  1. Manjuli R. Sharma
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  2. Prem S. Kaushal
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  3. Mona Gupta
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  4. Nilesh K. Banavali
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  5. Rajendra K. Agrawal
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Corresponding author

Correspondence to Rajendra K. Agrawal .

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Editors and Affiliations

  1. Institut de Biologie Moleculaire des Plantes, Strasbourg CX, France

    Anne-Marie Duchêne

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Sharma, M.R., Kaushal, P.S., Gupta, M., Banavali, N.K., Agrawal, R.K. (2013). Insights into Structural Basis of Mammalian Mitochondrial Translation. In: Duchêne, AM. (eds) Translation in Mitochondria and Other Organelles. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39426-3_1

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