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Carbonylative Sonogashira Reactions

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Transition Metal Catalyzed Carbonylation Reactions

Abstract

The Sonogashira reaction is generally known as a coupling reaction of terminal alkynes with aryl or vinyl halides. This reaction was first reported by Sonogashira and Hagihara in 1975. Today the Sonogashira coupling reaction is one of most powerful processes for C–C bond formation, especially for the synthesis of substituted alkynes. From the reaction mechanism aspect, a transmetalation step was included between the palladium center and the in situ-formed organocopper intermediate.

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Authors and Affiliations

  1. Leibniz Institute for Catalysis, Universität Rostock, Albert-Einstein-Strasse 29a, 18059, Rostock, Germany

    Matthias Beller & Xiao-Feng Wu

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  1. Matthias Beller
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  2. Xiao-Feng Wu
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Correspondence to Matthias Beller .

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Beller, M., Wu, XF. (2013). Carbonylative Sonogashira Reactions. In: Transition Metal Catalyzed Carbonylation Reactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39016-6_5

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