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HTLV-1 and Leukemogenesis: Virus–Cell Interactions in the Development of Adult T-Cell Leukemia

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Viruses and Human Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 193))

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1) was originally discovered in the early 1980s. It is the first retrovirus to be unambiguously linked causally to a human cancer. HTLV-1 currently infects approximately 20 million people worldwide. In this chapter, we review progress made over the last 30 years in our understanding of HTLV-1 infection, replication, gene expression, and cellular transformation.

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Acknowledgments

Work in our laboratory is supported in part by intramural funding from the NIAID and by the IATAP program from the Office of the Director, NIH. We thank Lauren Lee for her assistance in the preparation of the figures.

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  1. Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, 20892-0460, USA

    Linda Zane & Kuan-Teh Jeang

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  1. Linda Zane
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  2. Kuan-Teh Jeang
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Correspondence to Kuan-Teh Jeang .

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  1. Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

    Mei Hwei Chang

  2. Molecular Virology Section, Lab. of Mole, National Institute of Allergy and Infect, Bethesda, Maryland, USA

    Kuan-Teh Jeang

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Zane, L., Jeang, KT. (2014). HTLV-1 and Leukemogenesis: Virus–Cell Interactions in the Development of Adult T-Cell Leukemia. In: Chang, M., Jeang, KT. (eds) Viruses and Human Cancer. Recent Results in Cancer Research, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38965-8_11

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