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Challenges and Opportunities for Respiratory Syncytial Virus Vaccines pp 155–171Cite as

The Adaptive Immune Response to Respiratory Syncytial Virus

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 372))

Abstract

Respiratory syncytial virus (RSV) causes severe respiratory disease in children, the elderly and immunocompromised individuals. The combined actions of CD4 and CD8 T cells play a critical role in terminating an acute RSV infection whereas antibodies can provide protection from re-infection. Despite eliciting an immune response that mediates clearance of the virus, immunity to the virus appears to wane over time and individuals remain susceptible to reinfection with RSV throughout their lifetime. The ineffectiveness of the natural infection to induce long-term immunity has hampered vaccine efforts and there is currently no licensed RSV vaccine. In this review, we summarize our current understanding of the adaptive immune response to RSV and its contribution to disease.

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Authors and Affiliations

  1. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA

    Steven M. Varga

  2. Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA

    Steven M. Varga

  3. Department of Microbiology, University of Iowa, Iowa City, IA, 52242, USA

    Steven M. Varga

  4. Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA, 22908, USA

    Thomas J. Braciale

  5. Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA, 22908, USA

    Thomas J. Braciale

  6. Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, VA, 22908, USA

    Thomas J. Braciale

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  1. Steven M. Varga
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  2. Thomas J. Braciale
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Correspondence to Steven M. Varga .

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Editors and Affiliations

  1. Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA

    Larry J. Anderson

  2. Vaccine Research Center, NIH Natl. Inst. of Allergy & Infect. Dis., Bethesda, Maryland, USA

    Barney S. Graham

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Varga, S.M., Braciale, T.J. (2013). The Adaptive Immune Response to Respiratory Syncytial Virus. In: Anderson, L., Graham, B. (eds) Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Current Topics in Microbiology and Immunology, vol 372. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38919-1_8

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