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Respiratory Syncytial Virus and Reactive Airway Disease

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Book cover Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 372))

Abstract

Reactive airway disease (RAD) is a general term for respiratory illnesses manifested by wheezing. Respiratory syncytial virus (RSV) results in wheezing, either by causing bronchiolitis or by inducing acute exacerbations of asthma. There has been a long-standing interest in whether severe RSV bronchiolitis in infancy is a risk factor for the development of asthma later in childhood. While epidemiologic studies have suggested that such a link exists, a very recent study suggests that infants with greater airways responsiveness to methacholine instead have an increased prevalence of severe RSV bronchiolitis. Increased airways responsiveness to methacholine has been implicated as a key factor for loss of lung function in asthmatic subjects, suggesting that instead of being causal, severe RSV infection may instead be a marker of a predisposing factor for asthma. In this chapter, we will explore the evidence that RSV infection leads to RAD in infants and adults, and how these different forms of RAD may be linked.

Funding: National Institutes of Health R01 HL 090664, R01 AI 070672, R01 AI 059108, GM 015431, R21 HL106446, U19AI095227, and Veteran Affairs (1I01BX000624).

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Authors and Affiliations

  1. Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

    Matthew T. Lotz

  2. Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA

    Martin L. Moore

  3. T-1218 Medical Center North, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN, 37232-2650, USA

    R. Stokes Peebles Jr.

Authors
  1. Matthew T. Lotz
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  2. Martin L. Moore
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  3. R. Stokes Peebles Jr.
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Correspondence to R. Stokes Peebles Jr. .

Editor information

Editors and Affiliations

  1. Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA

    Larry J. Anderson

  2. Vaccine Research Center, NIH Natl. Inst. of Allergy & Infect. Dis., Bethesda, Maryland, USA

    Barney S. Graham

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Lotz, M.T., Moore, M.L., Peebles, R.S. (2013). Respiratory Syncytial Virus and Reactive Airway Disease. In: Anderson, L., Graham, B. (eds) Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Current Topics in Microbiology and Immunology, vol 372. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38919-1_5

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