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Effect of Fibre Orientation Optimisation in an Electromechanical Model of Left Ventricular Contraction in Rat

  • Conference paper
Functional Imaging and Modeling of the Heart (FIMH 2013)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 7945))

Abstract

Subject-specific, or personalised, modelling is one of the main targets in current cardiac modelling research. The aim of this study is to assess the improvement in predictive power gained by introducing subject-specific fibre models within an electromechanical model of left ventricular contraction in rat. A quantitative comparison of a series of global rule-based fibre models with an image-based locally optimised fibre model was performed. Our results show small difference in the predicted values of ejection fraction, wall thickening and base-to-apex shortening between the fibre models considered. In comparison, much larger differences appear between predicted values and those measured in experimental images. Further study of the constitutive behaviour and architecture of cardiac tissue is required before electromechanical models can fully benefit from the introduction of subject-specific fibres. Additionally, our study shows that, in the current model, an orthotropic description of the tissue is preferable to a transversely isotropic one, for the metrics considered.

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Author information

Authors and Affiliations

  1. Department of Computer Science, University of Oxford, UK

    Valentina Carapella, Rafel Bordas, Pras Pathmanathan, Peter Kohl, Kevin Burrage & Vicente Grau

  2. Department of Cardiovascular Medicine, University of Oxford, UK

    Jurgen E. Schneider

  3. National Heart and Lung Institute, Imperial College London, UK

    Peter Kohl

  4. Department of Engineering Science and Oxford e-Research Centre, University of Oxford, UK

    Vicente Grau

Authors
  1. Valentina Carapella
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  2. Rafel Bordas
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  3. Pras Pathmanathan
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  4. Jurgen E. Schneider
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  5. Peter Kohl
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  6. Kevin Burrage
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  7. Vicente Grau
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Editor information

Editors and Affiliations

  1. Centre for Medical Image Computing, University College London, Front Engineering Building, Malet Place, WC1E 6BT, London, UK

    Sébastien Ourselin

  2. Department of Computing, Imperial College London, 180 Queen’s Gate, SW7 2AZ, London, UK

    Daniel Rueckert

  3. Imaging Sciences & Biomedical Division, St. Thomas Hospital, King’s College London, St. Thomas Hospital, SE1 7EH, London, UK

    Nicolas Smith

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Carapella, V. et al. (2013). Effect of Fibre Orientation Optimisation in an Electromechanical Model of Left Ventricular Contraction in Rat. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-38899-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38898-9

  • Online ISBN: 978-3-642-38899-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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