The Effect of Active Cross-Fiber Stress on Shear-Induced Myofiber Reorientation
It has been hypothesized that myofiber orientation adapts to achieve a preferred mechanical loading state. To test this hypothesis, a model has been proposed in which myofiber orientation adapts in a response to fiber cross-fiber shear. However, the model lacked active cross-fiber stress that significantly reduces shear amplitudes, according to models of left ventricular (LV) mechanics. Therefore, we included generation of active stress perpendicular to the myofiber direction in an LV mechanics model with shear-induced myofiber reorientation. We tested the effect on fiber orientation, global and local LV function, and shear deformation. The developed pattern of the transverse component in myofiber orientation was similar with and without active cross-fiber stress. Angles of the transverse component were smaller with active cross-fiber stress. In both cases, global and local function increased during restructuring of the LV wall. Amplitudes of circumferential-radial shear strain were decreased after reorientation in both cases, and predicted and measured circumferential-radial shear strain matched better when active cross-fiber stress was included.
KeywordsShear Strain Transverse Component Heart Circ Helix Angle Rigid Body Rotation
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