Dimensional Reduction of Cardiac Models for Effective Validation and Calibration
Complex 3D beating heart models are now available, but their complexity makes calibration and validation very difficult tasks. We thus propose a systematic approach of deriving simplified reduced-dimensional models, in “0D” – typically, to represent a cardiac cavity, or several coupled cavities – and in “1D” – to model elongated structures such as fibers or myocytes. As illustrations of our approach, we demonstrate model validation based on experiments performed with papillary muscles, and calibration using patient-specific pressure-volume loops.
KeywordsDimensional Reduction Papillary Muscle Myosin Head Couple Cavity Cardiac Cavity
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