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Estimation of In Vivo Myocardial Fibre Strain Using an Architectural Atlas of the Human Heart

  • Christopher Casta
  • Vicky Y. Wang
  • Yue-Min Zhu
  • Brett R. Cowan
  • Pierre Croisille
  • Alistair A. Young
  • Martyn P. Nash
  • Patrick Clarysse
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7945)

Abstract

We propose a methodology to estimate 3D+time maps of left ventricular (LV) fibre strain from human structural and dynamic MRI data. A biomechanical finite element model integrates fibre direction throughout the LV extracted from ex vivo human diffusion tensor MRI (DT-MRI) acquisition and motion tracked from tagged MRI (TMRI). This combination enables the estimation of fibre strain and its spatio-temporal variation throughout the cardiac cycle. The sensitivity of fibre strain estimation on the underlying fibre orientation is evaluated using a database of 7 DT-MRI and 1 TMRI datasets acquired on normal subjects. Our analysis indicates that the structure of the LV is designed for maximum homogeneity of fibre strain during ejection.

Keywords

Human cardiac fibre strain Tagged MRI Diffusion tensor MRI FE modelling Statistical analysis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Christopher Casta
    • 1
  • Vicky Y. Wang
    • 2
  • Yue-Min Zhu
    • 1
  • Brett R. Cowan
    • 3
  • Pierre Croisille
    • 1
  • Alistair A. Young
    • 2
    • 3
  • Martyn P. Nash
    • 2
    • 4
  • Patrick Clarysse
    • 1
  1. 1.CREATIS, CNRS UMR5220, INSERM U1044, INSA-LyonUniv. de LyonFrance
  2. 2.Auckland Bioengineering InstituteUniversity of AucklandNew Zealand
  3. 3.Centre for Advanced MRIUniversity of AucklandNew Zealand
  4. 4.Department of Engineering ScienceUniversity of AucklandNew Zealand

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