Noninvasive Localization of Ectopic Foci: A New Optimization Approach for Simultaneous Reconstruction of Transmembrane Voltages and Epicardial Potentials
The goal of ECG imaging is the reconstruction of cardiac electrical activities from the potentials measured on the thorax surface. The tool can gain prominent clinical value for diagnosis and pre-interventional planning. The problem is however ill-posed, i.e. it is highly sensitive to modelling and measurement errors. In order to overcome this obstacle a regularization technique must be applied. In this paper we propose a new optimization based method for simultaneous reconstruction of transmembrane voltages and epicardial potentials for localizing the origin of ventricular ectopic beats.
Compared to second-order Tikhonov regularization, the new approach showed superior performance in marking activated regions and provided meaningful results where Tikhonov method failed.
KeywordsInverse Problem Transmembrane Voltage Ventricular Ectopic Beat Cardiac Electrical Activity Bidomain Model
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