Noninvasive Localization of Ectopic Foci: A New Optimization Approach for Simultaneous Reconstruction of Transmembrane Voltages and Epicardial Potentials

  • Danila Potyagaylo
  • Max Segel
  • Walther H. W. Schulze
  • Olaf Dössel
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7945)


The goal of ECG imaging is the reconstruction of cardiac electrical activities from the potentials measured on the thorax surface. The tool can gain prominent clinical value for diagnosis and pre-interventional planning. The problem is however ill-posed, i.e. it is highly sensitive to modelling and measurement errors. In order to overcome this obstacle a regularization technique must be applied. In this paper we propose a new optimization based method for simultaneous reconstruction of transmembrane voltages and epicardial potentials for localizing the origin of ventricular ectopic beats.

Compared to second-order Tikhonov regularization, the new approach showed superior performance in marking activated regions and provided meaningful results where Tikhonov method failed.


Inverse Problem Transmembrane Voltage Ventricular Ectopic Beat Cardiac Electrical Activity Bidomain Model 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Danila Potyagaylo
    • 1
  • Max Segel
    • 1
  • Walther H. W. Schulze
    • 1
  • Olaf Dössel
    • 1
  1. 1.Institute of Biomedical EngineeringKarlsruhe Institute of Technology (KIT)KarlsruheGermany

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