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Understanding Prenatal Brain Sparing by Flow Redistribution Based on a Lumped Model of the Fetal Circulation

  • Patricia Garcia-Canadilla
  • Paula Rudenick
  • Fatima Crispi
  • Monica Cruz-Lemini
  • Georgina Palau
  • Eduard Gratacos
  • Bart H. Bijnens
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7945)

Abstract

Intrauterine Growth Restriction due to placental insufficiency leads to cardiac dysfunction in utero which can persist postnatally. Brain sparing by flow redistribution is an adaptive mechanism used by the restricted fetus to ensure delivery of oxygenated blood to the brain. The quantification of reversed flow in the aortic isthmus is used in clinical practice to detect signs of brain sparing. Two parameters are used to quantify reversed flow: pulsatility index and isthmic flow index. We developed a simplified 0-D lumped model of the fetal circulation to simulate brain-sparing for better understanding this compensatory mechanism and its influence on the mentioned parameters. We were able to reproduce the clinical phenomenon and to quantify the effect of brain sparing on pulsatility and isthmic flow indexes. Therefore, our model seems to be a good approximation of the fetal circulation and offers potential to study hemodynamic changes in intrauterine growth restricted fetuses.

Keywords

Peripheral Resistance Pulsatility Index Blood Velocity Arterial Segment Intrauterine Growth Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Patricia Garcia-Canadilla
    • 1
    • 2
  • Paula Rudenick
    • 3
  • Fatima Crispi
    • 1
    • 4
  • Monica Cruz-Lemini
    • 1
  • Georgina Palau
    • 2
  • Eduard Gratacos
    • 1
    • 4
  • Bart H. Bijnens
    • 2
    • 5
  1. 1.Fetal and Perinatal Medicine Research GroupInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)BarcelonaSpain
  2. 2.Physense, N-RASUniversitat Pompeu FabraBarcelonaSpain
  3. 3.University Hospital and Research Institute Vall d’Hebron, Universitat Autonoma de BarcelonaBarcelonaSpain
  4. 4.Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)BarcelonaSpain
  5. 5.Institució Catalana de Recerca i Estudis Avançats (ICREA)BarcelonaSpain

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