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Cytopathology in the Diagnosis of Lymphoma

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 160))

Abstract

Fine needle aspiration (FNA) is a relatively simple, safe, and cost-effective procedure that has been used for decades in the evaluation of lymphadenopathy and mass lesions. However, its role in the diagnosis of lymphoma remains controversial. The key to enhancing the accuracy of FNA diagnosis of lymphoma is the multiparameter approach in which the cytomorphologic features should be interpreted in correlation with the results of ancillary studies and clinical context. This chapter focuses on the lymphomas that are more commonly encountered in cytopathology. The cytomorphologic, immunophenotypic, and molecular genetic features of various lymphoma subtypes and their diagnostic pitfalls are discussed.

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References

  1. Buley ID (1998) Fine needle aspiration of lymph nodes. J Clin Pathol 51:881–885

    Article  PubMed  CAS  Google Scholar 

  2. Serrano Egea A, Martinez Gonzalez MA, Perez Barrios A, Alberti Masgrau N, de Agustin P (2002) Usefulness of light microscopy in lymph node fine needle aspiration biopsy. Acta Cytol 46:364–368

    Google Scholar 

  3. Nasuti JF, Yu G, Boudousquie A, Gupta P (2000) Diagnostic value of lymph node fine needle aspiration cytology: an institutional experience of 387 cases observed over a 5-year period. Cytopathology 11:18–31

    Article  PubMed  CAS  Google Scholar 

  4. Kardos TF, Maygarden SJ, Blumberg AK, Wakely PE Jr, Frable WJ (1989) Fine needle aspiration biopsy in the management of children and young adults with peripheral lymphadenopathy. Cancer 63:703–707

    Article  PubMed  CAS  Google Scholar 

  5. Sandhaus LM (2000) Fine-needle aspiration cytology in the diagnosis of lymphoma. The next step. Am J Clin Pathol 113:623–627

    Article  PubMed  CAS  Google Scholar 

  6. Nakahara O, Yamao K, Bhatia V et al (2009) Usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for undiagnosed intra-abdominal lymphadenopathy. J Gastroenterol 44:562–567

    Article  PubMed  Google Scholar 

  7. Catalano MF, Nayar R, Gress F et al (2002) EUS-guided fine needle aspiration in mediastinal lymphadenopathy of unknown etiology. Gastrointest Endosc 55:863–869

    Article  PubMed  Google Scholar 

  8. Hayder S, Das DK, Bjork O, Lowhagen T (1988) Fine needle aspiration cytology (FNAC) of the testes in childhood acute lymphoblastic leukemia and non-Hodgkin’s lymphoma: preliminary report. Pediatr Hematol Oncol 5:29–34

    Article  PubMed  CAS  Google Scholar 

  9. de Almeida MM, Chagas M, de Sousa JV, Mendonca ME (1994) Fine-needle aspiration cytology as a tool for the early detection of testicular relapse of acute lymphoblastic leukemia in children. Diagn Cytopathol 10:44–46

    Article  PubMed  Google Scholar 

  10. Russell J, Orell S, Skinner J, Seshadri R (1983) Fine needle aspiration cytology in the management of lymphoma. Aust N Z J Med 13:365–368

    Article  PubMed  CAS  Google Scholar 

  11. Hehn ST, Grogan TM, Miller TP (2004) Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol 22:3046–3052

    Article  PubMed  Google Scholar 

  12. Landgren O, Porwit MacDonald A, Tani E et al (2004) A prospective comparison of fine-needle aspiration cytology and histopathology in the diagnosis and classification of lymphomas. Hematol J 5:69–76

    Article  PubMed  Google Scholar 

  13. Tarantino DR, McHenry CR, Strickland T, Khiyami A (1998) The role of fine-needle aspiration biopsy and flow cytometry in the evaluation of persistent neck adenopathy. Am J Surg 176:413–417

    Article  PubMed  CAS  Google Scholar 

  14. Wakely PE Jr (2000) Fine-needle aspiration cytopathology in diagnosis and classification of malignant lymphoma: accurate and reliable? Diagn Cytopathol 22:120–125

    Article  PubMed  Google Scholar 

  15. Das DK (1999) Value and limitations of fine-needle aspiration cytology in diagnosis and classification of lymphomas: a review. Diagn Cytopathol 21:240–249

    Article  PubMed  CAS  Google Scholar 

  16. Swerdlow SH CE, Harrie NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of tumours of Haematopoietic and lymphoid tissues. IARC, Lyon

    Google Scholar 

  17. Caraway NP (2005) Strategies to diagnose lymphoproliferative disorders by fine-needle aspiration by using ancillary studies. Cancer 105:432–442

    Article  PubMed  Google Scholar 

  18. Dey P (2006) Role of ancillary techniques in diagnosing and subclassifying non-Hodgkin’s lymphomas on fine needle aspiration cytology. Cytopathology 17:275–287

    Article  PubMed  CAS  Google Scholar 

  19. Verstovsek G, Chakraborty S, Ramzy I, Jorgensen JL (2002) Large B-cell lymphomas: fine-needle aspiration plays an important role in initial diagnosis of cases which are falsely negative by flow cytometry. Diagn Cytopathol 27:282–285

    Article  PubMed  Google Scholar 

  20. Kocjan G (2005) Best Practice No 185. Cytological and molecular diagnosis of lymphoma. J Clin Pathol 58:561–567

    Article  PubMed  CAS  Google Scholar 

  21. Young NA, Al-Saleem T (1999) Diagnosis of lymphoma by fine-needle aspiration cytology using the revised European-American classification of lymphoid neoplasms. Cancer 87:325–345

    Article  PubMed  CAS  Google Scholar 

  22. Barroca H, Marques C, Candeias J (2008) Fine needle aspiration cytology diagnosis, flow cytometry immunophenotyping and histology in clinically suspected lymphoproliferative disorder: a comparative study. Acta Cytol 52:124–132

    Article  PubMed  Google Scholar 

  23. Bangerter M, Brudler O, Heinrich B, Griesshamnuer M (2007) Fine needle aspiration cytology and flow cytometry in the diagnosis and subclassification of non-Hodgkin’s lymphoma based on the World Health Organization classification. Acta Cytol 51:390–398

    Article  PubMed  Google Scholar 

  24. Mathiot C, Decaudin D, Klijanienko J et al (2006) Fine-needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions. Diagn Cytopathol 34:472–478

    Article  PubMed  Google Scholar 

  25. Liu K, Stern RC, Rogers RT, Dodd LG, Mann KP (2001) Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: a review of 127 cases. Diagn Cytopathol 24:1–10

    Article  PubMed  Google Scholar 

  26. Meda BA, Buss DH, Woodruff RD et al (2000) Diagnosis and subclassification of primary and recurrent lymphoma. The usefulness and limitations of combined fine-needle aspiration cytomorphology and flow cytometry. Am J Clin Pathol 113:688–699

    Article  PubMed  CAS  Google Scholar 

  27. Monaco SE, Teot LA, Felgar RE, Surti U, Cai G (2009) Fluorescence in situ hybridization studies on direct smears: an approach to enhance the fine-needle aspiration biopsy diagnosis of B-cell non-Hodgkin lymphomas. Cancer Cytopathol 117:338–348

    Article  CAS  Google Scholar 

  28. Al-Haddad M, Savabi MS, Sherman S et al (2009) Role of endoscopic ultrasound-guided fine-needle aspiration with flow cytometry to diagnose lymphoma: a single center experience. J Gastroenterol Hepatol 24:1826–1833

    Article  PubMed  Google Scholar 

  29. Geisinger KR, Stanley MW, Raab SS, Silverman JF, Abati A (2003) Modern cytopathology. Churchill Livingstone, Philadelphia

    Google Scholar 

  30. Caraway NP, Gu J, Lin P, Romaguera JE, Glassman A, Katz R (2005) The utility of interphase fluorescence in situ hybridization for the detection of the translocation t(11;14)(q13;q32) in the diagnosis of mantle cell lymphoma on fine-needle aspiration specimens. Cancer 105:110–118

    Article  PubMed  Google Scholar 

  31. Gong Y, Caraway N, Gu J et al (2003) Evaluation of interphase fluorescence in situ hybridization for the t(14;18)(q32;q21) translocation in the diagnosis of follicular lymphoma on fine-needle aspirates: a comparison with flow cytometry immunophenotyping. Cancer 99:385–393

    Article  PubMed  Google Scholar 

  32. Gong JZ, Snyder MJ, Lagoo AS et al (2004) Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma. Diagn Cytopathol 31:23–30

    Article  PubMed  Google Scholar 

  33. Ho AK, Hill S, Preobrazhensky SN, Miller ME, Chen Z, Bahler DW (2009) Small B-cell neoplasms with typical mantle cell lymphoma immunophenotypes often include chronic lymphocytic leukemias. Am J Clin Pathol 131:27–32

    Article  PubMed  Google Scholar 

  34. Gao J, Peterson L, Nelson B, Goolsby C, Chen YH (2009) Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol 132:699–706

    Article  PubMed  Google Scholar 

  35. Beck RC, Stahl S, O’Keefe CL, Maciejewski JP, Theil KS, Hsi ED (2003) Detection of mature T-cell leukemias by flow cytometry using anti-T-cell receptor V beta antibodies. Am J Clin Pathol 120:785–794

    Article  PubMed  CAS  Google Scholar 

  36. Collins RD (1997) Is clonality equivalent to malignancy: specifically, is immunoglobulin gene rearrangement diagnostic of malignant lymphoma? Hum Pathol 28:757–759

    Article  PubMed  CAS  Google Scholar 

  37. Saxena A, Alport EC, Moshynska O, Kanthan R, Boctor MA (2004) Clonal B cell populations in a minority of patients with Hashimoto’s thyroiditis. J Clin Pathol 57:1258–1263

    Article  PubMed  CAS  Google Scholar 

  38. Saxena A, Moshynska O, Kanthan R, Bhutani M, Maksymiuk AW, Lukie BE (2000) Distinct B-cell clonal bands in Helicobacter pylori gastritis with lymphoid hyperplasia. J Pathol 190:47–54

    Article  PubMed  CAS  Google Scholar 

  39. Witzens M, Mohler T, Willhauck M, Scheibenbogen C, Lee KH, Keilholz U (1997) Detection of clonally rearranged T-cell-receptor gamma chain genes from T-cell malignancies and acute inflammatory rheumatic disease using PCR amplification, PAGE, and automated analysis. Ann Hematol 74:123–130

    Article  PubMed  CAS  Google Scholar 

  40. Dunphy CH, Katz RL, Fanning CV, Dalton WT Jr (1989) Leukemic lymphadenopathy: diagnosis by fine needle aspiration. Hematol Pathol 3:35–44

    PubMed  CAS  Google Scholar 

  41. Jacobs JC, Katz RL, Shabb N, el-Naggar A, Ordonez NG, Pugh W (1992) Fine needle aspiration of lymphoblastic lymphoma. A multiparameter diagnostic approach. Acta Cytol 36:887–894

    PubMed  CAS  Google Scholar 

  42. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma (1997). The Non-Hodgkin’s Lymphoma Classification Project. Blood 89:3909–3918

    Google Scholar 

  43. Binet JL, Auquier A, Dighiero G et al (1981) A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48:198–206

    Article  PubMed  CAS  Google Scholar 

  44. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46:219–234

    PubMed  CAS  Google Scholar 

  45. Hallek M, Cheson BD, Catovsky D et al (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111:5446–5456

    Article  PubMed  CAS  Google Scholar 

  46. Molica S (2010) A systematic review on Richter syndrome: what is the published evidence? Leuk Lymphoma 51:415–421

    Google Scholar 

  47. Tsimberidou AM, O’Brien S, Kantarjian HM et al (2006) Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Cancer 107:1294–1302

    Article  PubMed  CAS  Google Scholar 

  48. Tsimberidou AM, Keating MJ (2006) Richter’s transformation in chronic lymphocytic leukemia. Semin Oncol 33:250–256

    Article  PubMed  Google Scholar 

  49. Catrina Reading F, Schlette EJ, Stewart JM, Keating MJ, Katz RL, Caraway NP (2007) Fine-needle aspiration biopsy findings in patients with small lymphocytic lymphoma transformed to hodgkin lymphoma. Am J Clin Pathol 128:571–578

    Google Scholar 

  50. Caraway NP, Thomas E, Khanna A et al (2008) Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival. Cancer 114:315–322

    Article  PubMed  Google Scholar 

  51. Young NA (2006) Grading follicular lymphoma on fine-needle aspiration specimens–a practical approach. Cancer 108:1–9

    Article  PubMed  Google Scholar 

  52. Janikova A, Mayer J, Kren L et al (2009) The persistence of t(14;18)-bearing cells in lymph nodes of patients with follicular lymphoma in complete remission: the evidence for ‘a lymphoma stem cell’. Leuk Lymphoma 50:1102–1109

    Article  PubMed  CAS  Google Scholar 

  53. Bosch F, Lopez-Guillermo A, Campo E et al (1998) Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer 82:567–575

    Article  PubMed  CAS  Google Scholar 

  54. Yin CC, Medeiros LJ, Cromwell CC et al (2007) Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma. Mod Pathol 20:1–7

    Article  PubMed  CAS  Google Scholar 

  55. Laszlo T, Matolcsy A (1999) Blastic transformation of mantle cell lymphoma: genetic evidence for a clonal link between the two stages of the tumour. Histopathology 35:355–359

    Article  PubMed  CAS  Google Scholar 

  56. Norton AJ, Matthews J, Pappa V et al (1995) Mantle cell lymphoma: natural history defined in a serially biopsied population over a 20-year period. Ann Oncol 6:249–256

    PubMed  CAS  Google Scholar 

  57. Armitage JO, Weisenburger DD (1998) New approach to classifying non-Hodgkin’s lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin’s Lymphoma Classification Project. J Clin Oncol 16:2780–2795

    PubMed  CAS  Google Scholar 

  58. Nathwani BN, Anderson JR, Armitage JO et al (1999) Marginal zone B-cell lymphoma: a clinical comparison of nodal and mucosa-associated lymphoid tissue types. Non-Hodgkin’s Lymphoma Classification Project. J Clin Oncol 17:2486–2492

    PubMed  CAS  Google Scholar 

  59. Berger F, Felman P, Thieblemont C et al (2000) Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients. Blood 95:1950–1956

    PubMed  CAS  Google Scholar 

  60. Arcaini L, Paulli M, Burcheri S et al (2007) Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease. Br J Haematol 136:301–304

    Article  PubMed  Google Scholar 

  61. Kaba S, Hirokawa M, Kuma S et al (2009) Cytologic findings of primary thyroid MALT lymphoma with extreme plasma cell differentiation: FNA cytology of two cases. Diagn Cytopathol 37:815–819

    Article  PubMed  Google Scholar 

  62. Remstein ED, Dogan A, Einerson RR et al (2006) The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America. Am J Surg Pathol 30:1546–1553

    Article  PubMed  Google Scholar 

  63. Watkins AJ, Huang Y, Ye H et al (2009) Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis. J Pathol 220:461–474

    Google Scholar 

  64. Pangalis GA, Angelopoulou MK, Vassilakopoulos TP, Siakantaris MP, Kittas C (1999) B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including Waldenstrom’s macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. Semin Hematol 36:104–114

    PubMed  CAS  Google Scholar 

  65. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS (2006) Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood 107:265–276

    Article  PubMed  CAS  Google Scholar 

  66. Blum KA, Lozanski G, Byrd JC (2004) Adult Burkitt leukemia and lymphoma. Blood 104:3009–3020

    Article  PubMed  CAS  Google Scholar 

  67. Das DK, Gupta SK, Pathak IC, Sharma SC, Datta BN (1987) Burkitt-type lymphoma. Diagnosis by fine needle aspiration cytology. Acta Cytol 31:1–7

    PubMed  CAS  Google Scholar 

  68. Stastny JF, Almeida MM, Wakely PE Jr, Kornstein MJ, Frable WJ (1995) Fine-needle aspiration biopsy and imprint cytology of small non-cleaved cell (Burkitt’s) lymphoma. Diagn Cytopathol 12:201–207

    Article  PubMed  CAS  Google Scholar 

  69. Bellan C, Lazzi S, Hummel M et al (2005) Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. Blood 106:1031–1036

    Article  PubMed  CAS  Google Scholar 

  70. Chittal SM, Alard C, Rossi JF et al (1990) Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin’s disease is a large B-cell lymphoma in evolution. Am J Surg Pathol 14:1024–1035

    Article  PubMed  CAS  Google Scholar 

  71. Miettinen M, Franssila KO, Saxen E (1983) Hodgkin’s disease, lymphocytic predominance nodular. Increased risk for subsequent non-Hodgkin’s lymphomas. Cancer 51:2293–2300

    Article  PubMed  CAS  Google Scholar 

  72. Mayall F, Darlington A, Harrison B (2003) Fine needle aspiration cytology in the diagnosis of uncommon types of lymphoma. J Clin Pathol 56:821–825

    Article  PubMed  CAS  Google Scholar 

  73. Shahabuddin MD, Raghuveer CV (2003) Reed-Sternberg-like cells in T-cell rich B-cell lymphoma: a diagnostic dilemma. Indian J Pathol Microbiol 46:55–56

    PubMed  CAS  Google Scholar 

  74. Tani E, Johansson B, Skoog L (1998) T-cell-rich B-cell lymphoma: fine-needle aspiration cytology and immunocytochemistry. Diagn Cytopathol 18:1–4

    Article  PubMed  CAS  Google Scholar 

  75. Galindo LM, Havlioglu N, Grosso LE (1996) Cytologic findings in a case of T-cell rich B-cell lymphoma: potential diagnostic pitfall in FNA of lymph nodes. Diagn Cytopathol 14:253–257; discussion 7–8

    Google Scholar 

  76. Delecluse HJ, Anagnostopoulos I, Dallenbach F et al (1997) Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 89:1413–1420

    PubMed  CAS  Google Scholar 

  77. Nador RG, Cesarman E, Chadburn A et al (1996) Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood 88:645–656

    PubMed  CAS  Google Scholar 

  78. Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM (2004) KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol 28:1401–1416

    Article  PubMed  Google Scholar 

  79. Hans CP, Weisenburger DD, Greiner TC et al (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103:275–282

    Article  PubMed  CAS  Google Scholar 

  80. Rizvi MA, Evens AM, Tallman MS, Nelson BP, Rosen ST (2006) T-cell non-Hodgkin lymphoma. Blood 107:1255–1264

    Article  PubMed  CAS  Google Scholar 

  81. Vose J, Armitage J, Weisenburger D (2008) International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 26:4124–4130

    Article  PubMed  Google Scholar 

  82. Stein H, Foss HD, Durkop H et al (2000) CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood 96:3681–3695

    PubMed  CAS  Google Scholar 

  83. Falini B (2001) Anaplastic large cell lymphoma: pathological, molecular and clinical features. Br J Haematol 114:741–760

    Article  PubMed  CAS  Google Scholar 

  84. Gascoyne RD, Aoun P, Wu D et al (1999) Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood 93:3913–3921

    PubMed  CAS  Google Scholar 

  85. Ng WK, Ip P, Choy C, Collins RJ (2003) Cytologic and immunocytochemical findings of anaplastic large cell lymphoma: analysis of ten fine-needle aspiration specimens over a 9-year period. Cancer 99:33–43

    Article  PubMed  Google Scholar 

  86. Kim SE, Kim SH, Lim BJ, Hong SW, Yang WI (2004) Fine needle aspiration cytology of small cell variant of anaplastic large cell lymphoma. A case report. Acta Cytol 48:254–258

    Article  PubMed  CAS  Google Scholar 

  87. Aljajeh IA, Das DK, Krajci D (1995) Ki-1-positive anaplastic large cell lymphoma initially diagnosed as Hodgkin’s disease by fine needle aspiration (FNA) cytology. Cytopathology 6:226–235

    Article  PubMed  CAS  Google Scholar 

  88. Juco J, Holden JT, Mann KP, Kelley LG, Li S (2003) Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am J Clin Pathol 119:205–212

    Article  PubMed  Google Scholar 

  89. Muzzafar T, Wei EX, Lin P, Medeiros LJ, Jorgensen JL (2009) Flow cytometric immunophenotyping of anaplastic large cell lymphoma. Arch Pathol Lab Med 133:49–56

    PubMed  Google Scholar 

  90. Foss HD, Demel G, Anagnostopoulos I, Araujo I, Hummel M, Stein H (1997) Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma. Pathobiology 65:83–90

    Article  PubMed  CAS  Google Scholar 

  91. Krenacs L, Wellmann A, Sorbara L et al (1997) Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin’s disease: evidence for distinct cellular origin. Blood 89:980–989

    PubMed  CAS  Google Scholar 

  92. Shin HJ, Thorson P, Gu J, Katz RL (2003) Detection of a subset of CD30+ anaplastic large cell lymphoma by interphase fluorescence in situ hybridization. Diagn Cytopathol 29:61–66

    Article  PubMed  Google Scholar 

  93. Krenacs L, Schaerli P, Kis G, Bagdi E (2006) Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells. Blood 108:1110–1111

    Article  PubMed  CAS  Google Scholar 

  94. de Leval L, Rickman DS, Thielen C et al (2007) The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 109:4952–4963

    Article  PubMed  Google Scholar 

  95. Mourad N, Mounier N, Briere J et al (2008) Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d’Etude des Lymphomes de l’Adulte (GELA) trials. Blood 111:4463–4470

    Article  PubMed  CAS  Google Scholar 

  96. Park BB, Ryoo BY, Lee JH et al (2007) Clinical features and treatment outcomes of angioimmunoblastic T-cell lymphoma. Leuk Lymphoma 48:716–722

    Article  PubMed  Google Scholar 

  97. Dogan A, Ngu LS, Ng SH, Cervi PL (2005) Pathology and clinical features of angioimmunoblastic T-cell lymphoma after successful treatment with thalidomide. Leukemia 19:873–875

    Article  PubMed  CAS  Google Scholar 

  98. Ng WK, Ip P, Choy C, Collins RJ (2002) Cytologic findings of angioimmunoblastic T-cell lymphoma: analysis of 16 fine-needle aspirates over 9-year period. Cancer 96:166–173

    Article  PubMed  Google Scholar 

  99. Rodriguez-Pinilla SM, Atienza L, Murillo C et al (2008) Peripheral T-cell lymphoma with follicular T-cell markers. Am J Surg Pathol 32:1787–1799

    Article  PubMed  Google Scholar 

  100. Yu H, Shahsafaei A, Dorfman DM (2009) Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma. Am J Clin Pathol 131:33–41

    Article  PubMed  Google Scholar 

  101. Tan BT, Warnke RA, Arber DA (2006) The frequency of B- and T-cell gene rearrangements and epstein-barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations. J Mol Diagn 8:466–475; quiz 527

    Google Scholar 

  102. Diehl V, Sextro M, Franklin J et al (1999) Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin’s disease and lymphocyte-rich classical Hodgkin’s disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin’s Disease. J Clin Oncol 17:776–783

    PubMed  CAS  Google Scholar 

  103. Anagnostopoulos I, Hansmann ML, Franssila K et al (2000) European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood 96:1889–1899

    PubMed  CAS  Google Scholar 

  104. Nogova L, Reineke T, Josting A et al (2005) Lymphocyte-predominant and classical Hodgkin’s lymphoma–comparison of outcomes. Eur J Haematol Suppl 75:106–110

    Google Scholar 

  105. Biasoli I, Stamatoullas A, Meignin V et al (2010) Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. Cancer 116:631–639

    Google Scholar 

  106. Huang JZ, Weisenburger DD, Vose JM et al (2004) Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant Hodgkin lymphoma: a report of 21 cases from the Nebraska Lymphoma Study Group. Leuk Lymphoma 45:1551–1557

    Article  PubMed  Google Scholar 

  107. Das DK, Francis IM, Sharma PN et al (2009) Hodgkin’s lymphoma: diagnostic difficulties in fine-needle aspiration cytology. Diagn Cytopathol 37:564–573

    Article  PubMed  Google Scholar 

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Chen, YH., Gong, Y. (2014). Cytopathology in the Diagnosis of Lymphoma. In: Nayar, R. (eds) Cytopathology in Oncology. Cancer Treatment and Research, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38850-7_9

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