Abstract
Different cytologic methods are frequently employed for diagnosis in lung lesions, as demand for less invasive procedures has increased. Fungal and viral organisms can be readily appreciated in both exfoliative and aspirated cytologic specimens. Cytopathologists play a vital role in the diagnosis of lung cancer as most of these neoplasms are diagnosed by small biopsies or cytology specimens. The need to report the precise histologic subtyping of the tumor has increased due to the selection of the targeted therapy for these patients. Molecular methods can be readily performed on cytologic specimens with accurate results.
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References
Linder J (2000) Lung cancer cytology. Something old, something new. Am J Clin Pathol 114(2):169–171
Mullan CP et al (2004) CT-guided fine-needle aspiration of lung nodules: effect on outcome of using coaxial technique and immediate cytological evaluation. Ulster Med J 73(1):32–36
Sidawy MK (2007) Fine needle aspiration cytology. In: Goldblum JR (ed) Foundations in diagnostic pathology. Churchill Livingstone, London, pp 159–199
DeMay R (1996) The art and science of cytopathology. American Society of Clinical Pathologists, Chicago, pp 948–981
Khajotia RR et al (1991) Induced sputum and cytological diagnosis of lung cancer. Lancet 338(8773):976–977
Larsen SS, Krasnik M, Vilmann P et al (2002) Endoscopic ultrasound guided biopsy of mediastinal lesions has a major impact on patient management. Thorax 57:98–103
Johnston WW (1984) Percutaneous fine needle aspiration biopsy of the lung. A study of 1,015 patients. Acta Cytol 28(3):218–224
Naryshkin S, Daniels J, Young NA (1992) Diagnostic correlation of fiberoptic bronchoscopic biopsy and bronchoscopic cytology performed simultaneously. Diagn Cytopathol 8(2):119–123
Zarbo RJ, Fenoglio-Preiser CM (1992) Interinstitutional database for comparison of performance in lung fine-needle aspiration cytology. A college of american pathologists Q-probe study of 5264 cases with histologic correlation. Arch Pathol Lab Med 116(5):463–470
Motherby H et al (1999) Diagnostic accuracy of effusion cytology. Diagn Cytopathol 20(6):350–357
Saad RS, Silverman JF (2009) Respiratory cytology: Differential diagnosis and pitfalls. Diagn Cytopathol 38:297–307
Roggli VL, Piantadosi CA, Bell DY (1986) Asbestos bodies in bronchoalveolar lavage fluid. A study of 20 asbestos-exposed individuals and comparison to patients with other chronic interstitial lung diseases. Acta Cytol 30(5):470–476
Edman JC et al (1988) Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature 334(6182):519–522
Maiese SC, Naryshkin S (1991) Diagnosis of Pneumocystis carinii by cytologic examination of Papanicolaou-stained sputum specimens. Diagn Cytopathol 7(1):111–112
Naryshkin S et al (1991) Cytology of treated and minimal Pneumocystis carinii pneumonia and a pitfall of the Grocott methenamine silver stain. Diagn Cytopathol 7(1):41–47
Ness MJ et al (1988) Detection of Candida antigen in bronchoalveolar lavage fluid. Acta Cytol 32(3):347–352
Weiss RL et al (1991) Diagnosis of cytomegalovirus pneumonitis on bronchoalveolar lavage fluid: comparison of cytology, immunofluorescence, and in situ hybridization with viral isolation. Diagn Cytopathol 7(3):243–247
Hughes JH et al (2005) Fine-needle aspiration of pulmonary hamartoma: a common source of false-positive diagnoses in the college of American pathologists interlaboratory comparison program in nongynecologic cytology. Arch Pathol Lab Med 129(1):19–22
Xiao S et al (1997) HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma. Am J Pathol 150(3):901–910
Siegel R, Naishadham D, Jemal A et al (2012) Cancer statistics. CA Cancer J Clin. 62(1):10–29
Travis WD, Brambilla E, Noguchi M, et al (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol : official publication of the International Association for the Study of Lung Cancer. 6(2):244–285
Bell DW et al (2005) Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 23(31):8081–8092
Li AR et al (2008) EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression. J Mol Diagn 10(3):242–248
Marty M et al (2005) Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 23(19):4265–4274
Sequist LV et al (2007) Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 25(5):587–595
Atkins KA (2004) The diagnosis of bronchioloalveolar carcinoma by cytologic means. Am J Clin Pathol 122(1):14–16
Ohori NP, Santa Maria EL (2004) Cytopathologic diagnosis of bronchioloalveolar carcinoma: does it correlate with the 1999 World Health Organization definition? Am J Clin Pathol 122(1):44–50
Mukhopadhyay S, Katzenstein AL (2011) Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol 35(1):15–25
Rekhtman N et al (2011) Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testing. J Thorac Oncol 6(3):451–458
Liu J, Farhood A (2004) Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors: a comparison of direct smears and cell block preparations. Cancer 102(2):109–114
Soga J, Yakuwa Y (1999) Bronchopulmonary carcinoids: An analysis of 1,875 reported cases with special reference to a comparison between typical carcinoids and atypical varieties. Ann Thorac Cardiovasc Surg 5(4):211–219
Nicholson SA, Ryan MR (2000) A review of cytologic findings in neuroendocrine carcinomas including carcinoid tumors with histologic correlation. Cancer 90(3):148–161
Travis WD et al (1998) Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol 22(8):934–944
Johnston WW (1985) The malignant pleural effusion. A review of cytopathologic diagnoses of 584 specimens from 472 consecutive patients. Cancer 56(4):905–909
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Zydowicz, S., Yeldandi, A., Raparia, K. (2014). Cytology of the Lung. In: Nayar, R. (eds) Cytopathology in Oncology. Cancer Treatment and Research, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38850-7_4
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DOI: https://doi.org/10.1007/978-3-642-38850-7_4
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