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DNA Nanotechnology: From Biology and Beyond

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Nucleic Acid Nanotechnology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 29))

Abstract

Over the past three decades, tremendous progress has been made in our understanding of how to use DNA molecules to design and construct intricate nanostructures and nanodevices and how to use these nanoconstructs as versatile tools to functionally arrange a variety of molecules and moieties with nanometer spatial resolution. This chapter summarizes recent development in DNA nanotechnology and addresses its potential applications in drug delivery, analysis and diagnosis, electronics, and photovoltaics.

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Abbreviations

ADP:

Adenosine diphosphate

aTAM:

abstract Tile Assembly Model

ATP:

Adenosine triphosphate

CHA:

Catalyzed hairpin assembly

CpG:

Cytosine-phosphate-guanine

DX:

Double crossover

FRET:

Fluorescence resonance energy transfer

GMP:

Good manufacturing practice

GOx:

Glucose oxidase

HB:

Helix bundle

HCR:

Hybridization chain reaction

HRP:

Horseradish peroxidase

IHF:

Integration host factor

JX2 :

A topoisomer of PX molecule, one end of JX2 rotates 180° relative to the PX molecule, producing two juxtaposed duplexes without crossovers in the middle

kTAM:

kinetic Tile Assembly Model

LAMP:

Loop-mediated isothermal amplification

OLED:

Organic light-emitting diodes

PDGF:

Platelet-derived growth factor

PX:

Paranemic crossover

ssDNA:

Single-stranded DNA

SST:

Single-stranded tile

STV:

Streptavidin

TLR9:

Toll-like receptor 9

TX:

Triple crossover

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Acknowledgments

This work was supported by the Welch Foundation (F-1654), the National Security Science and Engineering Faculty Fellowship (FA9550-10-1-0169), and the National Institutes of Health (1 R01 GM094933-02). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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  1. Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA

    Chunhua Liu & Andrew D. Ellington

  2. Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX, 78712, USA

    Chunhua Liu & Andrew D. Ellington

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  1. Chunhua Liu
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Correspondence to Andrew D. Ellington .

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  1. Dept. of Molecular Biology, University of Aarhus, Center for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus C, Denmark

    Jørgen Kjems

  2. Center for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, Denmark

    Elena Ferapontova

  3. Center for DNA Nanotechnology, Interdisciplinary Nanoscience Center and Department of Chemistry, Aarhus University, Aarhus C, Denmark

    Kurt V. Gothelf

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Liu, C., Ellington, A.D. (2014). DNA Nanotechnology: From Biology and Beyond. In: Kjems, J., Ferapontova, E., Gothelf, K. (eds) Nucleic Acid Nanotechnology. Nucleic Acids and Molecular Biology, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38815-6_6

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