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A Note on Neoplastic Skin Lesions

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Abstract

Most of the benign and all of the malignant cutaneous neoplasias can be taken as mosaic lesions. They usually reflect either loss of heterozygosity or postzygotic new mutations present in a heterozygous state. By tradition, benign melanocytic proliferations are called nevi. All other benign cutaneous neoplasias do not represent nevi. For these tumors and for some malignant neoplasias such as basal cell carcinoma, the two-hit model may not always be true. Rather, a four-mutation model of tumorigenesis may be envisaged. For other malignant skin tumors such as squamous cell carcinoma or malignant melanoma, a multistep model of carcinogenesis can be taken as certain.

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Authors and Affiliations

  1. Department of Dermatology, Freiburg University Medical Center, Freiburg, Germany

    Rudolf Happle

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  1. Rudolf Happle
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© 2014 Springer-Verlag Berlin Heidelberg

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Happle, R. (2014). A Note on Neoplastic Skin Lesions. In: Mosaicism in Human Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38765-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-38765-4_13

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38764-7

  • Online ISBN: 978-3-642-38765-4

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