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Definition and Classification of Pulmonary Hypertension

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Pharmacotherapy of Pulmonary Hypertension

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 218))

Abstract

Pulmonary hypertension is defined as an increase of mean pulmonary arterial pressure ≥25 mmHg at rest as assessed by right heart catheterization. According to different combinations of values of pulmonary wedge pressure, pulmonary vascular resistance and cardiac output, a hemodynamic classification of pulmonary hypertension has been proposed. Of major importance is the pulmonary wedge pressure which allows to distinguish pre-capillary (pulmonary wedge pressure ≤15 mmHg) and post-capillary (pulmonary wedge pressure >15 mmHg) pulmonary hypertension. Pre-capillary pulmonary hypertension includes the clinical groups 1 (pulmonary arterial hypertension), 3 (pulmonary hypertension due to lung diseases and/or hypoxia), 4 (chronic thrombo-embolic pulmonary hypertension) and 5 (pulmonary hypertension with unclear and/or multifactorial mechanisms). Post-capillary pulmonary hypertension corresponds to the clinical group 2 (pulmonary hypertension due to left heart diseases).

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Authors and Affiliations

  1. Faculté de Médecine, Univ Paris-Sud, Le Kremlin-Bicêtre, France

    Marc Humbert, David Montani & Gérald Simonneau

  2. Inserm U999, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France

    Marc Humbert, David Montani & Gérald Simonneau

  3. Service de Pneumologie et Réanimation respiratoire, Hôpital Bicêtre, Assistance Publique – Hôpitaux de Paris, 78, rue Gabriel Péri, 94270, Le Kremlin-Bicêtre, France

    Marc Humbert, David Montani & Gérald Simonneau

  4. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Oleg V. Evgenov

Authors
  1. Marc Humbert
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  2. David Montani
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  3. Oleg V. Evgenov
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  4. Gérald Simonneau
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Correspondence to Marc Humbert .

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Editors and Affiliations

  1. Faculte´ de Me´decine, Univ Paris-Sud, Le Kremlin Bicêtre, France

    Marc Humbert

  2. Dep of Anasthesia and Critical Care, Harvard Medical School Massachusetts General Hospital, Boston, Massachusetts, USA

    Oleg V. Evgenov

  3. Cardiovascular Research, Bayer Pharma AG, Wuppertal, Germany

    Johannes-Peter Stasch

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Humbert, M., Montani, D., Evgenov, O.V., Simonneau, G. (2013). Definition and Classification of Pulmonary Hypertension. In: Humbert, M., Evgenov, O., Stasch, JP. (eds) Pharmacotherapy of Pulmonary Hypertension. Handbook of Experimental Pharmacology, vol 218. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38664-0_1

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