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Systems Biology of Metabolic and Signaling Networks pp 3–17Cite as

From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity

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Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 16))

Abstract

Systems Biology represents a new paradigm aiming at a whole organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. Historically, the roots of Systems Biology are multiple and of a diverse nature, comprising theoretical and conceptual developments, mathematical and modeling tools, and comprehensive analytical methodologies aimed at listing molecular components.

As a systemic approach, modern Systems Biology is deeply rooted in Integrative Physiology from which it inherits two big foundational principles: (1) a non-reductionist, integrative, view and (2) the capability of defining the context within which genes and their mutations will find meaning.

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Author information

Authors and Affiliations

  1. School of Medicine, Johns Hopkins University, Baltimore, MD, 21205l, USA

    M. A. Aon

  2. School of Biosciences, Cardiff University, Main Building, Museum Avenue, Cathays Park, Cardiff CF, 10 3AT, Wales, UK

    D. Lloyd

  3. INSERM U1055 Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France

    V. Saks

  4. Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia

    V. Saks

Authors
  1. M. A. Aon
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  2. D. Lloyd
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  3. V. Saks
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Correspondence to M. A. Aon .

Editor information

Editors and Affiliations

  1. School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

    Miguel A. Aon

  2. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Valdur Saks

  3. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Uwe Schlattner

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Aon, M.A., Lloyd, D., Saks, V. (2014). From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity. In: Aon, M., Saks, V., Schlattner, U. (eds) Systems Biology of Metabolic and Signaling Networks. Springer Series in Biophysics, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38505-6_1

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