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Non-coding RNAs in Dictyostelium discoideum and Other Dictyostelid Social Amoebae

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Dictyostelids

Abstract

Non-coding (nc)RNAs have recently emerged as ubiquitous and important regulators of a multitude of different processes, such as stress response, cell differentiation, infection, and cell death. The means by which ncRNAs affect these processes are numerous and diverse, ranging from protein localization to regulation of gene expression. ncRNA-mediated gene expression control has been the subject of especially intense study in recent years and has shown to occur through several mechanisms. Different ncRNAs can regulate gene expression transcriptionally by inducing modification of DNA or chromatin, or post-transcriptionally by directing cleavage, degradation, or translational inhibition of messenger (m)RNAs. ncRNAs come in a broad spectrum of sizes, from ~20 nucleotides (nt) to several thousand nt, and function in complexes with various proteins that usually exert a catalytic function while the RNAs act as guides. In Dictyostelia, we have only started to understand the extent of ncRNA regulation, mostly from studies in Dictyostelium discoideum, which is the focus of this chapter.

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Acknowledgments

We thank present and former members of the laboratory for experimental input and helpful discussions. This work was supported by The Swedish Research Council (to F.S. and to Uppsala RNA Research Center), The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), and the European Community (FOSRAK, EC005120).

Author information

Author notes

  1. Lotta Avesson

    Present address: Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia

  2. Fredrik Söderbom

    Present address: Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Box 596, S-75124, Uppsala, Sweden

Authors and Affiliations

  1. Department of Molecular Biology, Biomedical Center, Swedish University of Agricultural Sciences, Box 590, SE-75124, Uppsala, Sweden

    Lotta Avesson & Fredrik Söderbom

  2. Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-75124, Uppsala, Sweden

    Andrea Hinas

  3. Science for Life Laboratory, SE-75124, Uppsala, Sweden

    Andrea Hinas & Fredrik Söderbom

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  1. Lotta Avesson
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Correspondence to Fredrik Söderbom .

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  1. , Department of Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Maria Romeralo

  2. , Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Sandra Baldauf

  3. Alberto Sols CSIC-UAM, Instituto de Investigaciones Biomedicas, Arturo Duperier 4, Madrd, 28029, Spain

    Ricardo Escalante

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Avesson, L., Hinas, A., Söderbom, F. (2013). Non-coding RNAs in Dictyostelium discoideum and Other Dictyostelid Social Amoebae. In: Romeralo, M., Baldauf, S., Escalante, R. (eds) Dictyostelids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38487-5_6

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