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Dictyostelium discoideum as a Model in Biomedical Research

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Dictyostelids

Abstract

The simple eukaryote Dictyostelium discoideum has been traditionally used to understand basic principles of cell and developmental biology and now has also become a useful system in biomedical research. What are the similarities and differences between D. discoideum and other simple microbial models such as Saccharomyces cerevisiae? Which aspects are more advantageous to address in D. discoideum? Are there any processes or specific proteins present in D. discoideum that are difficult or impossible to study in other systems? Does it make sense to use such a simple organism in biomedicine? These and other questions will be addressed in this chapter, together with some specific examples in which D. discoideum has proved its potential to model human disease.

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Acknowledgments

This work was supported by grants BFU2009-09050 and BFU2012-32536 from the Spanish Ministerio de Ciencia e Innovación. Thanks to Dr. Ron Hartong for linguistic assistance and suggestions. A.M. is supported by a FPI fellowship from the Spanish Government. S.M.B. has been supported by "Obra Social Caja de Burgos y Fundación Gutiérrez Manrique”.

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  1. Instituto de Investigaciones Biomedicas Alberto Sols, CSIC-UAM, Arturo Duperier 4, 28029, Madrid, Spain

    Sandra Muñoz-Braceras, Ana Mesquita & Ricardo Escalante

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  1. Sandra Muñoz-Braceras
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Correspondence to Ricardo Escalante .

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  1. , Department of Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Maria Romeralo

  2. , Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Sandra Baldauf

  3. Alberto Sols CSIC-UAM, Instituto de Investigaciones Biomedicas, Arturo Duperier 4, Madrd, 28029, Spain

    Ricardo Escalante

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Muñoz-Braceras, S., Mesquita, A., Escalante, R. (2013). Dictyostelium discoideum as a Model in Biomedical Research. In: Romeralo, M., Baldauf, S., Escalante, R. (eds) Dictyostelids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38487-5_1

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