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The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness

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Epigenetic Therapy of Cancer

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Abstract

In eukaryotes, DNA packaging into nucleosomes and higher-order chromatin structures is able to prevent the operation of the nuclear factors in charge of genetic functions. For this reason, during all DNA-templated cellular processes, chromatin structures must undergo dynamic remodeling (opening and closing of higher-order structures) in order to regulate access to their corresponding DNA segments. Epigenetics comprises a highly connected, dynamic set of mechanisms through which cells can execute this key remodeling: DNA methylation, covalent histone modifications, histone variants, and ATP-dependent chromatin-remodeling complexes. Additionally, microRNAs are usually incorporated into the same category, as their regulation can directly affect, and be affected by, the former. Disruption of any of these processes, which are essential for cell renewal, differentiation, and stemness, is intimately linked with cancer.

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Authors and Affiliations

  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet, Barcelona, Spain

    Manuel Rodríguez-Paredes & Manel Esteller

  2. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain

    Manel Esteller

  3. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

    Manel Esteller

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  1. Manuel Rodríguez-Paredes
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Correspondence to Manuel Rodríguez-Paredes or Manel Esteller .

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  1. Department of Hematology/Oncology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany

    Michael Lübbert

  2. Norris Comprehensive Cancer Center Urologic Cancer Res. Lab., University of Southern California Dept. Biochemistry & Molecular Biology, Los Angeles, California, USA

    Peter A. Jones

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Rodríguez-Paredes, M., Esteller, M. (2014). The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness. In: Lübbert, M., Jones, P. (eds) Epigenetic Therapy of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38404-2_1

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