Skip to main content

Eyelid Tumors: Cutaneous Melanoma

  • Chapter
  • First Online:
Clinical Ophthalmic Oncology

Abstract

Cutaneous melanoma of the eyelid is a rare tumor, representing fewer than 1 % of all malignant neoplasms of the eyelid skin [1], 1 % of all skin melanomas [2], and 7 % of cutaneous malignant melanomas of the head and neck region [3]. Many primary melanomas of the eyelid involve the mucosal surfaces of the palpebral and bulbar conjunctiva, and in these cases, one must manage not only the eyelid but also the conjunctival component of the lesion. One may argue reasonably that primary conjunctival melanomas may affect the eyelid secondarily.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cook Jr BE, Bartley GB. Treatment options and future prospects for the management of eyelid malignancies: an evidence-based update. Ophthalmology. 2001;108(11):2088–100.

    Article  PubMed  Google Scholar 

  2. Rodriguez-Sains RS, Jakobiec FA, Iwamoto T. Lentigo maligna of the lateral canthal skin. Ophthalmology. 1981;88(12):1186–92.

    PubMed  CAS  Google Scholar 

  3. Batsakis J. Tumors of the head and neck. Baltimore: Williams and Wilkins; 1974.

    Google Scholar 

  4. Naidoff MA, Bernardino VB, Clark WH. Melanocytic lesions of the eyelid skin. Am J Ophthalmol. 1976;82(3):371–82.

    PubMed  CAS  Google Scholar 

  5. Garner A, Koornneef L, Levene A, et al. Malignant melanoma of the eyelid skin: histopathology and behaviour. Br J Ophthalmol. 1985;69(3):180–6.

    Article  PubMed  CAS  Google Scholar 

  6. Zoltie N, O’Neill TJ. Malignant melanomas of eyelid skin. Plast Reconstr Surg. 1989;83(6):994–6.

    Article  PubMed  CAS  Google Scholar 

  7. Grossniklaus HE, McLean IW. Cutaneous melanoma of the eyelid. Clinicopathologic features. Ophthalmology. 1991;98(12):1867–73.

    PubMed  CAS  Google Scholar 

  8. Tahery DP, Goldberg R, Moy RL. Malignant melanoma of the eyelid. A report of eight cases and a review of the literature. J Am Acad Dermatol. 1992;27(1):17–21.

    Article  PubMed  CAS  Google Scholar 

  9. Vaziri M, Buffam FV, Martinka M, et al. Clinicopathologic features and behavior of cutaneous eyelid melanoma. Ophthalmology. 2002;109(5):901–8.

    Article  PubMed  Google Scholar 

  10. Chan FM, O’Donnell BA, Whitehead K, et al. Treatment and outcomes of malignant melanoma of the eyelid: a review of 29 cases in Australia. Ophthalmology. 2007;114(1):187–92.

    Article  PubMed  Google Scholar 

  11. Wang JK, Liao SL, Jou JR, et al. Malignant eyelid tumours in Taiwan. Eye. 2003;17(2):216–20.

    Article  PubMed  Google Scholar 

  12. Takamura H, Yamashita H. Clinicopathological analysis of malignant eyelid tumor cases at Yamagata University Hospital: statistical comparison of tumor incidence in Japan and in other countries. Jpn J Ophthalmol. 2005;49(5):349–54.

    Article  PubMed  Google Scholar 

  13. Then SY, Malhotra R, Barlow R, et al. Early cure rates with narrow-margin slow-Mohs surgery for periocular malignant melanoma. Dermatol Surg. 2009;35(1):17–23.

    Article  PubMed  CAS  Google Scholar 

  14. Kostopoulos E, Champsas G, Konofaos P, et al. Eyelid melanoma: our experience a propos of 23 cases. Ann Chir Plast Esthet. 2012;57(2):158–63.

    Article  PubMed  CAS  Google Scholar 

  15. Patel BC, Egan CA, Lucius RW, et al. Cutaneous malignant melanoma and oculodermal melanocytosis (nevus of Ota): report of a case and review of the literature. J Am Acad Dermatol. 1998;38(5 Pt 2):862–5.

    Article  PubMed  CAS  Google Scholar 

  16. Demirci H, Johnson TM, Frueh BR, et al. Management of periocular cutaneous melanoma with a staged excision technique and permanent sections: the square procedure. Ophthalmology. 2008;115(12):2295–300.

    Article  PubMed  Google Scholar 

  17. Clark Jr WH, From L, Bernardino EA, et al. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969;29(3):705–27.

    PubMed  Google Scholar 

  18. Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970;172(5):902–8.

    Article  PubMed  CAS  Google Scholar 

  19. Harris MN, Shapiro RL, Roses DF. Malignant melanoma. Primary surgical management (excision and node dissection) based on pathology and staging. Cancer. 1995;75(2 Suppl):715–25.

    Article  PubMed  CAS  Google Scholar 

  20. Malhotra R, Chen C, Huilgol S, et al. Mapped serial excision for periocular lentigo maligna and lentigo maligna melanoma. Ophthalmology. 2003;110(10):2011–8.

    Article  PubMed  Google Scholar 

  21. Boulos PR, Rubin PA. Cutaneous melanomas of the eyelid. Semin Ophthalmol. 2006;21(3):195–206.

    Article  PubMed  Google Scholar 

  22. Esmaeli B, Youssef A, Naderi A, et al. for the Collaborative Eyelid Skin Melanoma Group. Margins of excision for cutaneous melanoma of the eyelid skin: the Collaborative Eyelid Skin Melanoma Group report. Ophthal Plast Reconstr Surg. 2003; 19(2):96–101.

    Google Scholar 

  23. Glat P, Longaker M, Jelks EB, et al. Periorbital melanocytic lesions: excision and reconstruction in 40 patients. Plast Reconstr Surg. 1998;102(1):19–27.

    Article  PubMed  CAS  Google Scholar 

  24. Stanowsky A, Krey HF, Kopp J, et al. Irradiation of malignant eyelid melanoma with Iodine-125 plaque. Am J Ophthalmol. 1990;110(1):44–8.

    PubMed  CAS  Google Scholar 

  25. Shiose S, Sakamoto T, Yoshikawa H, et al. Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma. Invest Ophthalmol Vis Sci. 2000;41(9):2395–403.

    PubMed  CAS  Google Scholar 

  26. Savar A, Ross MI, Prieto VG, et al. Sentinel lymph node biopsy for ocular adnexal melanoma: experience in 30 patients. Ophthalmology. 2009;116(11):2217–23.

    Article  PubMed  Google Scholar 

  27. Esmaeli B, Wang B, Deavers M, et al. Prognostic factors for survival in malignant melanoma of the eyelid skin. Ophthal Plast Reconstr Surg. 2000;16(4):250–7.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jacob Pe’er MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Pe’er, J., Folberg, R. (2014). Eyelid Tumors: Cutaneous Melanoma. In: Pe'er, J., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38336-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-38336-6_7

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38335-9

  • Online ISBN: 978-3-642-38336-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics