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Clinical Ophthalmic Oncology pp 229–239Cite as

Systemic Associations

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Abstract

Conjunctival tumors may be some of the prominent manifestations of systemic inherited diseases. In such instances, ophthalmologists should recognize the systemic association and initiate appropriate systemic and genetic evaluation. Conjunctival tumors and tumor-like conditions with syndromic association can be considered under the categories of pigmented lesions (Peutz–Jeghers syndrome), benign tumors (Goldenhar syndrome), malignant tumors (xeroderma pigmentosum), and amyloidosis (Table 22.1). We will briefly review such conjunctival lesions and the associated systemic disorders. Other entities may also have associated eyelid tumors and are covered in detail elsewhere (see Chaps. 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11). Where applicable, inheritance patterns of the syndromic association and molecular genetics are also included.

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Author information

Authors and Affiliations

  1. Cleveland Clinic Lerner College of Medicine (NA-21), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Lucy T. Xu BSc

  2. Center for Genetic Eye Diseases, Cole Eye Institute(i-32), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Lucy T. Xu BSc

  3. Department of Ophthalmic Oncology, Cole Eye Institute and Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Arun D. Singh MD

  4. Department of Pediatric Ophthalmology and Strabismus, Center for Genetic Eye Diseases, Cole Eye Institute (i-32), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Elias I. Traboulsi MD

Authors
  1. Lucy T. Xu BSc
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  2. Arun D. Singh MD
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  3. Elias I. Traboulsi MD
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Correspondence to Arun D. Singh MD .

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Editors and Affiliations

  1. Department of Ophthalmology, Hadassah-Hebrew University, Jerusalem, Israel

    Jacob Pe'er

  2. Dept. of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

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Xu, L.T., Singh, A.D., Traboulsi, E.I. (2014). Systemic Associations. In: Pe'er, J., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38336-6_22

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  • DOI: https://doi.org/10.1007/978-3-642-38336-6_22

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