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Rule-Based Formalization of Eligibility Criteria for Clinical Trials

  • Zhisheng Huang
  • Annette ten Teije
  • Frank van Harmelen
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7885)

Abstract

In this paper, we propose a rule-based formalization of eligibility criteria for clinical trials. The rule-based formalization is implemented by using the logic programming language Prolog. Compared with existing formalizations such as pattern-based and script-based languages, the rule-based formalization has the advantages of being declarative, expressive, reusable and easy to maintain. Our rule-based formalization is based on a general framework for eligibility criteria containing three types of knowledge: (1) trial-specific knowledge, (2) domain-specific knowledge and (3) common knowledge. This framework enables the reuse of several parts of the formalization of eligibility criteria. We have implemented the proposed rule-based formalization in SemanticCT, a semantically-enabled system for clinical trials, showing the feasibility of using our rule-based formalization of eligibility criteria for supporting patient recruitment in clinical trial systems.

Keywords

Eligibility Criterion Invasive Lobular Carcinoma SPARQL Query Temporal Reasoning Trial Feasibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Zhisheng Huang
    • 1
  • Annette ten Teije
    • 1
  • Frank van Harmelen
    • 1
  1. 1.Department of Computer ScienceVU University AmsterdamThe Netherlands

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