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Squamous Cell Carcinoma of the Lip

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Book cover Lip Cancer

Abstract

The lips serve as the functional sphincter of the oral cavity, oropharynx, and entryway to the upper aerodigestive tract and play a critical role in speech, deglutition, and oral-motor function. Lip cancer in general refers to epithelial malignancies that take origin form the vermillion of the lower lip (de Visscher and van der Waal 1998). Lip cancer is frequently grouped analytically with oral cavity cancers; however, the etiopathogenesis is notably different. For all intent and purposes, lip cancer is more closely related to skin cancer than to oral cavity squamous cell carcinoma and therefore warrants separate and distinct discussion regarding its pathogenesis.

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References

  1. Abreu MA, Silva OM, Neto Pimentel DR, Hirata CH, Weckx LL, Alchorne MM, Michalany NS (2006) Actinic cheilitis adjacent to squamous carcinoma of the lips as an indicator of prognosis. Braz J Otorhinolaryngol 72(6):767–771

    PubMed  Google Scholar 

  2. Berg D, Otley CC (2002) Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol 47(1):1–17; quiz 18–20

    Article  PubMed  Google Scholar 

  3. Blomqvist G, Hirsch JM, Alberius P (1991) Association between development of lower lip cancer and tobacco habits. J Oral Maxillofac Surg 49(10):1044–1047; discussion 1048–1049

    Article  PubMed  CAS  Google Scholar 

  4. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ (1996) Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Investig Dermatol Symp Proc 1(2):136–142

    PubMed  CAS  Google Scholar 

  5. Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP (2010) Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. J Am Acad Dermatol 62(1):31–37

    Article  PubMed  CAS  Google Scholar 

  6. Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y, Khavari PA (2003) NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421(6923):639–643

    Article  PubMed  CAS  Google Scholar 

  7. de Visscher JG, van der Waal I (1998) Etiology of cancer of the lip. A review. Int J Oral Maxillofac Surg 27(3):199–203

    Article  PubMed  Google Scholar 

  8. English DR, Armstrong BK, Kricker A, Fleming C (1997) Sunlight and cancer. Cancer Causes Control 8(3):271–283

    Article  PubMed  CAS  Google Scholar 

  9. English DR, Armstrong BK, Kricker A, Winter MG, Heenan PJ, Randell PL (1998) Demographic characteristics, pigmentary and cutaneous risk factors for squamous cell carcinoma of the skin: a case-control study. Int J Cancer 76(5):628–634

    Article  PubMed  CAS  Google Scholar 

  10. Gallagher RP, Hill GB, Bajdik CD, Coldman AJ, Fincham S, McLean DI, Threlfall WJ (1995) Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer. II. Squamous cell carcinoma. Arch Dermatol 131(2):164–169

    Article  PubMed  CAS  Google Scholar 

  11. Grodstein F, Speizer FE, Hunter DJ (1995) A prospective study of incident squamous cell carcinoma of the skin in the nurses’ health study. J Natl Cancer Inst 87(14):1061–1066

    Article  PubMed  CAS  Google Scholar 

  12. Hall J, Artuso M, English DR (1996) Molecular epidemiology of skin cancers: DNA repair and non-melanocytic skin cancer. Ann Ist Super Sanita 32(1):43–51

    PubMed  CAS  Google Scholar 

  13. Hutchinson F (1994) Induction of tandem-base change mutations. Mutat Res 309(1):11–15

    Article  PubMed  CAS  Google Scholar 

  14. Jadotte YT, Schwartz RA (2012) Solar cheilosis: an ominous precursor: part I. Diagnostic insights. J Am Acad Dermatol 66(2):173–184; quiz 185–176

    Article  PubMed  Google Scholar 

  15. Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP (2008) EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol 10(8):902–911

    Article  PubMed  CAS  Google Scholar 

  16. Kricker A, Armstrong BK, English DR (1994) Sun exposure and non-melanocytic skin cancer. Cancer Causes Control 5(4):367–392

    Article  PubMed  CAS  Google Scholar 

  17. Lopez-Pintor RM, Hernandez G, de Arriba L, de Andres A (2011) Lip cancer in renal transplant patients. Oral Oncol 47(1):68–71

    Article  PubMed  Google Scholar 

  18. Nakazawa H, English D, Randell PL, Nakazawa K, Martel N, Armstrong BK, Yamasaki H (1994) UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc Natl Acad Sci U S A 91(1):360–364

    Article  PubMed  CAS  Google Scholar 

  19. O’Donovan P, Perrett CM, Zhang X, Montaner B, Xu YZ, Harwood CA, McGregor JM, Walker SL, Hanaoka F, Karran P (2005) Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 309(5742):1871–1874

    Article  PubMed  Google Scholar 

  20. Perea-Milla Lopez E, Minarro-Del Moral RM, Martinez-Garcia C, Zanetti R, Rosso S, Serrano S, Aneiros JF, Jimenez-Puente A, Redondo M (2003) Lifestyles, environmental and phenotypic factors associated with lip cancer: a case-control study in southern Spain. Br J Cancer 88(11):1702–1707

    Article  PubMed  CAS  Google Scholar 

  21. Pogoda JM, Preston-Martin S (1996) Solar radiation, lip protection, and lip cancer risk in Los Angeles county women (California, United States). Cancer Causes Control 7(4):458–463

    Article  PubMed  CAS  Google Scholar 

  22. Ratushny V, Gober MD, Hick R, Ridky TW, Seykora JT (2012) From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest 122(2):464–472

    Article  PubMed  CAS  Google Scholar 

  23. Rehman I, Takata M, Wu YY, Rees JL (1996) Genetic change in actinic keratoses. Oncogene 12(12):2483–2490

    PubMed  CAS  Google Scholar 

  24. Rigel DS (2008) Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol 58(5 Suppl 2):S129–S132

    Article  PubMed  Google Scholar 

  25. Rosso S, Zanetti R, Martinez C, Tormo MJ, Schraub S, Sancho-Garnier H, Franceschi S, Gafa L, Perea E, Navarro C, Laurent R, Schrameck C, Talamini R, Tumino R, Wechsler J (1996) The multicentre south European study ‘Helios’. II: different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. Br J Cancer 73(11):1447–1454

    Article  PubMed  CAS  Google Scholar 

  26. Spitzer WO, Hill GB, Chambers LW, Helliwell BE, Murphy HB (1975) The occupation of fishing as a risk factor in cancer of the lip. N Engl J Med 293(9):419–424

    Article  PubMed  CAS  Google Scholar 

  27. Swerdlow AJ, Cooke KR, Skegg DC, Wilkinson J (1995) Cancer incidence in England and Wales and New Zealand and in migrants between the two countries. Br J Cancer 72(1):236–243

    Article  PubMed  CAS  Google Scholar 

  28. van Leeuwen MT, Grulich AE, McDonald SP, McCredie MR, Amin J, Stewart JH, Webster AC, Chapman JR, Vajdic CM (2009) Immunosuppression and other risk factors for lip cancer after kidney transplantation. Cancer Epidemiol Biomarkers Prev 18(2):561–569

    Article  PubMed  Google Scholar 

  29. Wei-Passanese EX, Han J, Lin W, Li T, Laden F, Qureshi AA (2012) Geographical variation in residence and risk of multiple nonmelanoma skin cancers in US women and men. Photochem Photobiol 88(2):483–489

    Article  PubMed  CAS  Google Scholar 

  30. Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP (2010) Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465(7296):368–372

    Article  PubMed  CAS  Google Scholar 

  31. Ziegler A, Jonason A, Simon J, Leffell D, Brash DE (1996) Tumor suppressor gene mutations and photocarcinogenesis. Photochem Photobiol 63(4):432–435

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Andrew Salama DDS, MD .

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© 2014 Springer-Verlag Berlin Heidelberg

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Salama, A. (2014). Squamous Cell Carcinoma of the Lip. In: Kolokythas, A. (eds) Lip Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38180-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-38180-5_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38179-9

  • Online ISBN: 978-3-642-38180-5

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