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Therapeutic Potential of Hydroxamic Acids for Microbial Diseases

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Hydroxamic Acids

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Abstract

Hydroxamic acid derivatives have recently been recommended for therapeutic treatment of several diseases, such as hypertension, cancer, as well as inflammations and infectious diseases due to their ability to chelate metals, especially in metalloenzymes. This chapter will focus on the role of metallopeptidases and their homologs in microbial diseases and the potential use of hydroxamates and their derivates for the treatment and control of such diseases. A general overview of the structure, synthesis, and inhibition mechanisms of hydroxamates as well as their potential use, including the advantages and relative problems, for medicinal chemistry will be discussed.

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Abbreviations

AAT:

Aminoglycoside acetyltransferases

AIDS:

Acquired immunodeficiency syndrome

ANTs:

Aminoglycoside nucleotidyltransferases

APH(3’)s:

Aminoglycoside 3′-phosphotransferases

BNZ:

Benznidazole

cART:

Combination antiretroviral therapy

DC:

Dendritic cells

ECM:

Extracellular matrix

Glu:

Glutamate

HDACs:

Histone deacetylases

HDACi:

Histone deacetylase inhibitors

HIV:

Human immunodeficiency virus

LmaCP1:

Leishmania major carboxypeptidase

LpxC:

UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase

LPS:

Lipopolysaccharide

MCPs:

Metallocarboxypeptidases

MMPs:

Matrix metalloproteinases

MRSA:

Gram-positive methicillin-resistant Staphylococcus aureus

MVEC:

macrovascular endothelial cells

NFX:

Nifurtimox

6-PGDH:

6-Phosphogluconate dehydrogenase

TcMCP-t :

Trypanosoma cruzi metallocarboxypeptidase-type

Ex. Trypanosoma cruzi metallocarboxypeptidase-1

TIMPs:

Tissue inhibitors of metalloproteinases

TNF-α:

Tumor necrosis factor-alpha

WHO:

World Health Organization

ZBG:

Zinc-binding group

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Acknowledgments

This work was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (MCT/CNPq), Coordenação de Aperfeiçoamento Pessoal de Nível Superior (CAPES).

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Authors and Affiliations

  1. Department of General Microbiology, Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Giseli Capaci Rodrigues & Alane Beatriz Vermelho

  2. Department of Science and Technology, Universidade do Grande Rio (UNIGRANRIO), Duque de Caxias, Rio de Janeiro, RJ, Brazil

    Giseli Capaci Rodrigues, Flavia Alexandra Gomes de Souza & Whei Oh Lin

  3. Biocatalysis, Bioproducts and Bioenergy Unit, Biotechnology Center-BIOINOVAR, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Alane Beatriz Vermelho

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  1. Giseli Capaci Rodrigues
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  4. Alane Beatriz Vermelho
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Correspondence to Alane Beatriz Vermelho .

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  1. Department of Pharmaceutical Technology Department of Applied Sciences, Meerut Institute of Engineering and Technology, Meerut, India

    Satya P. Gupta

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Rodrigues, G.C., de Souza, F.A.G., Lin, W.O., Vermelho, A.B. (2013). Therapeutic Potential of Hydroxamic Acids for Microbial Diseases. In: Gupta, S. (eds) Hydroxamic Acids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38111-9_10

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