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Polyurethane Implant (ACTIFIT)

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Book cover Meniscal Transplantation

Abstract

Increased awareness of potentially detrimental outcomes following partial meniscectomy led to the development of a novel meniscal scaffold, Actifit™, by Orteq Bioengineering. It received the CE Mark in July 2008 for treatment of medial or lateral irreparable partial meniscal tears. Actifit™ consists of highly interconnected porous synthetic material enabling tissue ingrowth. Over time, transformation into meniscus-like tissue takes place as the implant slowly degrades. Furthermore, Actifit™ is made of an aliphatic polyurethane, which provides optimal mechanical strength, biocompatibility, porosity, safe degradation and ease of use required for the indication. It is available in two shapes, medial and lateral.

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Notes

  1. 1.

    Kamerlingheplein 16, 9712 TR, Groningen, The Netherlands. e-mail: jenhde.groot@wxs.nl

  2. 2.

    Department of Orthopaedics and Trauma, University Hospital, De Pintelaan 185, 9000 Gent, Belgium. e-mail: Rene.verdonk@ugent.be

  3. 3.

    Department of orthopaedics and trauma, Monica ziekenhuizen, 2000 Antwerpen, Belgium.

  4. 4.

    Tissue Therapies Europe Limited, Unit F34, Daresbury Innovation Centre, Keckwick Lane, Daresbury, Cheshire WA4 4FS, England. e-mail: heinrichsel@aol.com

References

  1. Elema H, de Groot JH, Nijenhuis AJ, Pennings AJ, Veth RPH, Klompmaker J, Jansen HWB (1990) Use of biodegradable polymer implants in meniscus reconstruction: 2 biological evaluation of porous biodegradable implants in menisci. Colloid Polym Sci 268:1082–1088

    Article  CAS  Google Scholar 

  2. de Groot JH (1995) Porous polymeric elastomers for repair and replacement of the knee joint meniscus. PhD thesis, State University Groningen, The Netherlands. http://dissertations.ub.rug.nl/FILES/faculties/science/1995/j.h.de.groot/titlecon.pdf

  3. de Groot JH, Nijenhuis AJ, Bruin P, Pennings AJ, Veth RPH, Klompmaker J, Jansen HWB (1990) Use of biodegradable polymer implants in meniscus reconstruction. 1 Preparation of porous biodegradable polyurethanes for the reconstruction of the meniscus. Colloid Polym Sci 268:1073–1081

    Article  Google Scholar 

  4. de Groot JH, de Vrijer R, Pennings AJ, Klompmaker J, Veth RPH, Jansen HWB (1996) Use of porous polyurethanes for meniscal reconstruction and prosthesis. Biomaterials 17:163–173

    Article  PubMed  Google Scholar 

  5. de Groot JH, Zijlstra FM, Kuipers HW, Pennings AJ, Klompmaker J, Veth RPH, Jansen HWB (1997) Meniscal tissue regeneration in porous 50/50 copoly (L-lactide/ε-caprolactone) implants. Biomaterials 18:613–622

    Article  PubMed  Google Scholar 

  6. de Groot JH, Kuiper HW, Pennings AJ (1997) A novel method for fabrication biodegradable scaffolds with high compression moduli. J Mater Sci Mater Med 8:703

    Article  Google Scholar 

  7. Heijkants RG, van Calck RV, van Tienen TG, de Groot JH, Pennings AJ, Buma P, Veth RP, Schouten AJ (2008) Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation. J Biomed Mater Res A 15(87):921–932

    Google Scholar 

  8. Klompmaker J (1992) Porous polymers for repair and replacement of the knee joint meniscus and articualr cartilage. PhD thesis, State University Groningen, The Netherlands

    Google Scholar 

  9. Klompmaker J, Jansen HWB, Veth RPH, de Groot JH, Nijenhuis AJ, Pennings AJ (1991) Porous polymer implants for repair of meniscal lesions: a preliminary study in dogs. Biomaterials 12:810–816

    Article  PubMed  CAS  Google Scholar 

  10. Klompmaker J, Jansen HWB, Veth RPH, de Groot JH, Penings Kuijer R (1992) Meniscal repair by fibrocartilage: An experimental study in the dog. J Orthop Res 10:359–370

    Article  PubMed  CAS  Google Scholar 

  11. Klompmaker J, Jansen HWB, Veth RPH, de Groot JH, Nijenhuis AJ, Pennings AJ (1992) Porous polymer implants for repair of full-thickness defects of articular cartilage: an experimental study in the dog. Biomaterials 13:625–634

    Article  PubMed  CAS  Google Scholar 

  12. Klompmaker J, Jansen HWB, Veth RPH, Nielsen HKL, de Groot JH, Pennings AJ (1994) Porous implants for the knee joint meniscus reconstruction: A preliminary study on the role of pore sizes in ingrowth and differentiation of fibrocartilage. Clin Mater 14:1–11

    Article  Google Scholar 

  13. Klompmaker J, Jansen HWB, Veth RPH, Nielsen NKL, de Groot JH, Pennings AJ (1996) Meniscal replacement using a porous polymer prosthesis: a preliminary study in the dog. Bimoaterials 17:1169–1176

    Article  CAS  Google Scholar 

  14. Lamba NMK, Woodhouse KA, Cooper SL (1998) Polyurethanes in Biomedical Applications. CRC press, Boca Raton

    Google Scholar 

  15. Leenslag JW (1987) Poly (L-lactide) and its biomedical applications. PhD thesis, State University Groningen, The Netherlands

    Google Scholar 

  16. Orteq report R08006 in vitro degradation study Actifit™

    Google Scholar 

  17. Spaans CJ, de Groot JH, Dekens FG, Veth RPH, Pennings AJ (1999) Development of new polyurethanes for repair and replacement of the knee joint meniscus. Polym Prep 40:589–590

    Article  CAS  Google Scholar 

  18. Spaans CJ, Belgraver VW, Rienstra OR, Veth RPH, de Groot JH, Pennings AJ (2000) Solvent-free fabrication of micro-porous polyurethane amide and polyurethane urea scaffolds for repair and replacement of the knee joint meniscus. Biomaterials 21:2453–2460

    Article  PubMed  CAS  Google Scholar 

  19. van Tienen TG (2004) In-vivo tissue engineering of knee joint meniscus. PhD thesis, University Nijmegen, The Netherlands

    Google Scholar 

  20. van Tienen TG, Heijkants RG, Buma P, de Groot JH, Pennings AJ, Veth RP (2002) Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes. Biomaterials 23:1731–1738

    Article  PubMed  Google Scholar 

  21. van Tienen TG, Heijkants RG, de Groot JH, Pennings AJ, Poole AR, Veth RP, Buma P (2003) Presence and mechanism of knee articular cartilage degeneration after meniscal reconstruction in dogs. Osteoarthritis Cartilage 11:78–84

    Article  PubMed  Google Scholar 

  22. Tienen TG, Heijkants RG, de Groot JH, Schouten AJ, Pennings AJ, Veth RP, Buma P (2006) Meniscal replacement in dogs. Tissue regeneration in two different materials with similar properties. J Biomed Mater Res B Appl Biomater 76:389–396

    PubMed  CAS  Google Scholar 

  23. Klompmaker J, Jansen HWB, Veth PRH, Nielsen NKL, de Groot JH, Pennings AJ, Kuijer R (1996) Meniscal repair by fibrocartilage in the dog: Characterization of the repair tissue and the role of vascularity. Biomaterials 17:1685–1692

    Article  PubMed  CAS  Google Scholar 

  24. van Tienen TG, Heijkants RG, Buma P, de Groot JH, Pennings AJ, Veth RP (2003) A porous polymer scaffold for meniscal lesion repair: A study in dogs. Biomaterials 24:2541–2548

    Article  PubMed  CAS  Google Scholar 

  25. de Groot JH, de Vrijer R, Wildeboer BS, Spaans CJ, Pennings AJ (1997) New biomedical polyurethane ureas with high tear strength. Polym Bull 38:211–218

    Article  Google Scholar 

  26. de Groot JH, Spaans CJ, Dekens FG, Pennings AJ (1998) On the role of aminolysis and transesterification in the synthesis of ε-caprolactone and L-lactide based polyurethanes. Polym Bull 41:299–306

    Article  Google Scholar 

  27. Heijkants RGJC (2004) Polyurethane scaffolds as meniscus reconstruction material. PhD thesis, State University Groningen, The Netherlands. http://dissertations.ub.rug.nl/faculties/science/2004/r.g.j.c.heijkants/

  28. Heijkants RG, van Calck RV, De Groot JH, Pennings AJ, Schouten AJ, van Tienen TG, Ramrattan N, Buma P, Veth RP (2004) Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration. J Mater Sci Mater Med 15:423–427

    Article  PubMed  CAS  Google Scholar 

  29. Heijkants RG, van Calck RV, van Tienen TG, de Groot JH, Buma P, Pennings AJ, Veth RP, Schouten AJ (2005) Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(epsilon-caprolactone) and 1,4-butane diisocyanate with uniform hard segment. Biomaterials 26:4219–4228

    Google Scholar 

  30. Orteq report R06036(2) Summary Biocompatibility Testing Actifit™

    Google Scholar 

  31. Ramrattan NN, Heijkants RG, van Tienen TG, Schouten AJ, Veth RP, Buma P (2005) Assessment of tissue ingrowth rates in polyurethane scaffolds for tissue engineering. Tissue Eng 11:1212–1223

    Article  PubMed  CAS  Google Scholar 

  32. Spaans CJ (2000) Biomedical polyurethanes based on 1,4-butanediisocyanate. PhD thesis, State University Groningen, The Netherlands

    Google Scholar 

  33. Spaans CJ, de Groot JH, Dekens FG, Pennings AJ (1998) High molecular weight polyurethanes and a polyurethane urea based on 1,4-butanediisocyanate. Polym Bull 41:131–138

    Article  CAS  Google Scholar 

  34. Maher SA, Doty SB, Rodeo SA, Brophy R, Potter H, Foo L, Rosenblatt L, Deng X-H, Turner AS, Wright TM, Warren RF. Evaluation of a Porous Polyurethane Scaffold in a partial meniscal defect ovine model. To be published

    Google Scholar 

  35. Veth RP, Jansen HW, Leenslag JW, Pennings AJ, Hartel RM, Nielsen HK (1986) Experimental meniscal lesions reconstructed with a carbon fiber-polyurethane-poly (L-lactide) graft. Clin Orthop Relat Res 202:286–293

    PubMed  CAS  Google Scholar 

  36. van Minnen B, van Leeuwen MB, Kors G, Zuidema J, van Kooten TG, Bos RR (2008) In vivo resorption of a biodegradable polyurethane foam, based on 1,4-butanediisocyanate: a three-year subcutaneous implantation study. J Biomed Mater Res A 15(85):972–982

    Google Scholar 

  37. Spaans CJ, Belgraver VW, de Groot JH, Pennings AJ (1998) A new biomedical polyurethane with a high modulus based on 1,4-butanediisocyanate. J Mater Sci Mater Med 9:675–678

    Article  PubMed  CAS  Google Scholar 

  38. Welsing RT, van Tienen TG, Ramrattan N, Heijkants R, Schouten AJ, Veth RP, Buma P (2008) Effect on tissue differentiation and articular cartilage degradation of a polymer meniscus implant: A 2-year follow-up study in dogs. Am J Sports Med 36:1978–1989

    Article  PubMed  Google Scholar 

  39. Zuidema J, van Minnen B, Span MM, Hissink CE, van Kooten TG, Bos RR (2008) In vitro degradation of a biodegradable polyurethane foam, based on 1,4-butanediisocyanate: A 3-year study at physiological and elevated temperature. J Biomed Mater Res A (Epub ahead of print)

    Google Scholar 

  40. Verdonk P, Verdonk R on behalf of the Actifit Study Group (2009) Clinical efficacy and safety of a resorbable meniscus scaffold for the treatment of partial meniscal tear or meniscal loss. International Meeting on Early Intervention for Knee Arthritis, Maastricht 4–6 February 2009

    Google Scholar 

  41. Leenslag JW, Nijenhuis AJ, Pennings AJ, Veth RPH, Nielsen HKL, Jansen HWB (1986) Porous composites for repair of the meniscus. Proceedings of the P.I.M.S V, Noordwijkerhout, The Netherlands, 10–12 September, pp 10/1–10/9

    Google Scholar 

  42. Tienen TG, Heijkants RG, de Groot JH, Pennings AJ, Schouten AJ, Veth RP, Buma P (2006) Replacement of the knee meniscus by a porous polymer implant: a study in dogs. Am J Sports Med 34:64–71

    Article  PubMed  Google Scholar 

  43. Verdonk P, Beaufils P, Bellemans J, Djian P, Heinrichs EL, Huysse W, Laprell H, Siebold R, Verdonk R, Actifit Study Group (2012) Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold: two-year safety and clinical outcomes. Am J Sports Med 40(4):844–853 (Epub 2012 Feb 9)

    Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedics and Trauma, University Hospital, De Pintelaan 185, 9000, Gent, Belgium

    Rene Verdonk

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  1. Rene Verdonk
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Correspondence to Rene Verdonk .

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Editors and Affiliations

  1. , Dept. of Orthopaedic Surgery and Traumat, Ghent University Hospital, De Pintelaan 18, Gent, 9000, Belgium

    René Verdonk

  2. Clínica Espregueira Mendes, Estádio do Dragão, Porto, 4350-415, Portugal

    João Espregueira Mendes

  3. , Dept. of Orthopaedic Surgery, Hospital de la Sta Creu i Sant Pau, St Antoni m Claret 167, Barcelona, 08025, Spain

    Joan Carles Monllau

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Verdonk, R. (2013). Polyurethane Implant (ACTIFIT). In: Verdonk, R., Espregueira Mendes, J., Monllau, J. (eds) Meniscal Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38106-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-38106-5_7

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38105-8

  • Online ISBN: 978-3-642-38106-5

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