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Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

  • Conference paper
Clinical Image-Based Procedures. From Planning to Intervention (CLIP 2012)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 7761))

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Abstract

Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more suitable for setup and execution errors. In this study we use the GTV delineations made by 6 experienced clinicians to create delineation-specific dose plans. These dose plans are then used to calculate theoretic tumor control probabilities (TCP) differences between delineations. The results show that current margin recipes are inadequate for maintaining the same TCP despite manual delineation variation. New methods to account for delineation variation should be developed.

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Author information

Authors and Affiliations

  1. Department of Informatics and Mathematical Modelling, Technical University of Denmark, Denmark

    Christian Hollensen & Rasmus Larsen

  2. Department of Radiation Oncology, University of Copenhagen, Rigshospitalet, Denmark

    Gitte Persson, Liselotte Højgaard & Lena Specht

  3. Department of Clinical Physiology, Nuclear Medicine and PET, University of Copenhagen, Rigshospitalet, Denmark

    Christian Hollensen, Gitte Persson, Liselotte Højgaard, Lena Specht & Rasmus Larsen

Authors
  1. Christian Hollensen
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  2. Gitte Persson
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  3. Liselotte Højgaard
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  4. Lena Specht
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  5. Rasmus Larsen
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Editor information

Editors and Affiliations

  1. Cognitive Computing and Medical Imaging, Fraunhofer IGD, Fraunhoferstr. 5, 64283, Darmstadt, Germany

    Klaus Drechsler , Cristina Oyarzun Laura  & Stefan Wesarg ,  & 

  2. Fraunhofer IDM@NTU, Nanyang Avenue, 639798, Singapore, Singapore

    Marius Erdt

  3. Children’s National Medical Center, Sheikh Zayed Institute for Pediatric Surgical Innovation, 111 Michigan Avenue,NW, 20010, Washington, D.C., USA

    Marius George Linguraru

  4. Interventional Radiology, Georgetown University Hospital, 3800 Reservoir Rd., NW, 20007-2113, Washington, D.C., USA

    Karun Sharma

  5. Children’s National Medical Center, Sheikh Zayed Institute for Pediatric Surgical Innovation, 111Michigan Avenue, NW, 20010, Washington, D.C., USA

    Raj Shekhar

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© 2013 Springer-Verlag Berlin Heidelberg

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Hollensen, C., Persson, G., Højgaard, L., Specht, L., Larsen, R. (2013). Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation. In: Drechsler, K., et al. Clinical Image-Based Procedures. From Planning to Intervention. CLIP 2012. Lecture Notes in Computer Science, vol 7761. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38079-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-38079-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38078-5

  • Online ISBN: 978-3-642-38079-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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