Abstract
Due to many reasons, potent and new antifungal agents are still required, especially for the large populations of immunocompromised patients; it is lifesaving to protect them from systemic infections. Scientists around the globe are hunting for new and potent antifungal molecules. Nature as well as ethnomedicine thought to be a very good source of novel molecules not only against fungal infections, but also against many other clinical complications, like cancers and so on. This chapter puts some emphasis on and discusses about the natural products as source of antifungal agents.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Afolayan AJ, Meyer JJ (1997) The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol 57(3):177–181
Arendrup MC, Fuursted K, Gahrn-Hansen B, Jensen IM, Knudsen JD, Lundgren B, Schonheydar HC, Tvede M (2005) Seminational surveillance of fungemia in Denmark: notably high rates of fungemia and numbers of isolates with reduced azole susceptibility. J Clin Microbiol 43(9):4434–4440
Arif T, Bhosale JD, Kumar N, Mandal TK, Bendre RS, Lavekar GS, Dabur R (2009) Natural products: antifungal agents derived from plants. J Asian Nat Prod Res 11(7):621–638
Arif T, Mandal TK, Dabur R (2011) Natural products: anti-fungal agents derived from plants. In: Tiwari VK, Mishra BB (eds) Opportunity, challenge and scope of natural products in medicinal chemistry. Research Signpost, Kerala, pp 283–311
Athikomkulchai S, Prawat H, Thasana N, Ruangrungsi N, Ruchirawat S (2006) COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus. Chem Pharm Bull 54(2):262–264 (Tokyo)
Bansod S, Rai M (2008) Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World J Med Sci 3(2):81–88
Bathoorn E, Escobar Salazar N, Sepehrkhouy S, Meijer M, de Cock H, Haas PJ (2013) Involvement of the opportunistic pathogen Aspergillus tubingensis in osteomyelitis of the maxillary bone: a case report. BMC Infect Dis 1(13):59. doi:10.1186/1471-2334-13-59
Bylka W, Szaufer-Hajdrych M, Mattawska I, Goślińska O (2004) Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. Lett Appl Microbiol 39(1):93–97
Chapman SW, Sullivan DC, Cleary JD (2008) In search of the holy grail of antifungal therapy. Trans Am Clin Climatol Assoc 119:197–215
Chen LC, Blank ES, Casadevall A (1996) Extracellular proteinase activity of Cryptococcus neoformans. Clin Diagn Lab Immunol 3(5):570–574
Cox PA, Balick MJ (1994) The ethnobotanical approach to drug discovery. Sci Am 270(6):82–87
Denning DW, Hope WW (2010) Therapy for fungal diseases: opportunities and priorities. Trends Microbiol 18(5):195–204
Dismukes WE (2012) Introduction to antifungal drugs. Guidelines for antibiotic therapy at the hospital of the University of Pennsylvania. Retrieved 13 July 2012, from http://www.uphs.upenn.edu/bugdrug/
Enoch DA, Ludlam HA, Brown NM (2006) Invasive fungal infections: a review of epidemiology and management options. J Med Microbiol 55(Pt 7):809–818
Espinel-Ingroff A (2009) Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005–2009). Rev Iberoam Micol 26(1):15–22
Espinell-IngroffAPfaller MA (1995) Antifungal agents and susceptibility testing. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds) Manual of clinical microbiology. ASM Press, Washington
Fabricant DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environ Health Prospect 109(1):69–75
Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, van Staden J (2004) Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. J Ethnopharmacol 94(2–3):205–217
Fortes TO, Alviano DS, Tupinambá G, Padrón TS, Antoniolli AR, Alviano CS, Seldin L (2008) Production of an antimicrobial substance against Cryptococcus neoformans by Paenibacillus brasilensis Sa3 isolated from the rhizosphere of Kalanchoe brasiliensis. Microbiol Res 163(2):200–207
Fostel JM, Lartey PA (2000) Emerging novel antifungal agents. Drug Discov Today 5(1):25–32
Garbino J, Kolarova L, Lew D, Hirschel B, Rohner P (2001) Fungemia in HIV-infected patients: a 12-year study in a tertiary care hospital. AIDS Patient Care STDS 15(8):407–410
Goa KL, Barradell LB (1995) Fluconazole: an update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients. Drugs 50(4):658–690
Grant SM, Clissold SP (1989) Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs 37(3):310–344
Grant SM, Clissold SP (1990) Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs 39(6):877–916
Gupta AK, Tomas E (2003) New antifungal agents. Dermatol Clin 21(3):565–576
Hassan W, Al-Gendy A, Al-Youssef H, El-Shazely A (2012) Chemical constituents and biological activities of Senecio aegyptius var. discoideus Boiss. Z Naturforsch [C] 67(3–4):144–150
Hoesley C, Dismukes WE (1997) Overview of oral azole drugs as systemic antifungal therapy. Semin Resp Crit Care Med 18:301–309
Hufford CD, Jia Y, Croom EM Jr, Muhammed I, Okunade AL, Clark AM, Rogers RD (1993) Antimicrobial compounds from Petalostemum purpureum. J Nat Prod 56(11):1878–1889
Jacob MR, Walker LA (2005) Natural products and antifungal drug discovery. Methods Mol Med 118:83–109
Johann S, Pizzolatti MG, Donnici CL, Resende MA (2007) Antifungal properties of plants used in Brazilian traditional medicine against clinically relevant fungal pathogens. Braz J Microbiol 38:632–637
Kauffman CA, Carver PL (1997a) Antifungal agents in the 1990s. Current status and future developments. Drugs 53(4):539–549
Kauffman CA, Carver PL (1997b) Use of azoles for systemic antifungal therapy. Adv Pharmacol 39:143–189
Lago JH, Ramos CS, Casanova DC, Morandim Ade A, Bergamo DC, Cavalheiro AJ, Bolzanivda S, Furlan M, Guimarães EF, Young MC, Kato MJ (2004) Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum. J Nat Prod 67(11):1783–1788
Lass-Florl C, Mayr A, Mayr A, Gastl G, Bonatti H, Freund M, Kropshofer G, Dierich MP, Nachbaur D (2005) Epidemiology and outcome of infections due to Aspergillus terreus: 10-year single centre experience. Br J Haematol 131(2):201–217
Ma WG et al (1995) Polyphenols from Eriosema tuberosum. Phytochemistry 39(5):1049–1061
Meena AK, Niranjan US, Rao MM, Padhi MM, Babu R (2009) Review on antifungal activities of Ayurvedic medicinal plants. Drug Invention Today 2(2):146–148
Motsei ML, Lindsey KL, van Staden J, Jäger AK (2003) Screening of traditionally used South African plants for antifungal activity against Candida albicans. J Ethnopharmacol 86(2–3):235–241
Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20(1):133–163
Rahman MM, Alam AH, Sadik G, Islam MR, Khondkar P, Hossain MA, Rashid MA (2007) Antimicrobial and cytotoxic activities of Achyranthes ferruginea. Fitoterapia 78(3):260–262
Resende JCP, Resende MA (1999) In vitro antifungal susceptibility of clinical isolates of Candida spp. from hospitalized patients. Mycoses 42:641–644
Saleh MA, Belal MH, el-Baroty G (2006) Fungicidal activity of Artemisia herba alba Asso (Asteraceae). J Environ Sci Health B 41(3):237–244
Svetaz L, Agüero MB, Alvarez S, Luna L, Feresin G, Derita M, Tapia A, Zacchino S (2007) Antifungal activity of Zuccagnia punctata Cav.: evidence for the mechanism of action. Planta Med 73(10):1074–1080
Tan RX, Wolfender JL, Ma WG, Zhang LX, Hostettmann K (1996a) Secoiridoids and antifungal aromatic acids from Gentiana algida. Phytochemistry 41(1):111–116
Tan RX, Wolfender JL, Zhang LX, Ma WG, Fuzzati N, Marston A, Hostettmann K (1996b) Acyl secoiridoids and antifungal constituents from Gentiana macrophylla. Phytochemistry 42(5):1305–1313
Vazquez JA (2007) Combination antifungal therapy: the new frontier. Future Microbiol 2(2):115–139
Vollekova A, Kost’álová D, Kettmann V, Tóth J (2003) Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytother Res 17(7):834–837
Webster D, Taschereau P, René J, Sand C, Belland, Robert P, Rennie R (2008) Antifungal activity of medicinal plant extracts; preliminary screening studies. J Ethnopharmacol 115(1):140–146
Yenesew A, Derese S, Midiwo JO, Bii CC, Heydenreich M, Peter MG (2005) Antimicrobial flavonoids from the stem bark of Erythrina burttii. Fitoterapia 76(5):469–472
Zhai B, Lin X (2011) Recent progress on antifungal drug development. Curr Pharm Biotechnol 12(8):1255–1262
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Khan, M.T.H. (2013). Natural Products as Potential Resources for Antifungal Substances: A Survey. In: Razzaghi-Abyaneh, M., Rai, M. (eds) Antifungal Metabolites from Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38076-1_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-38076-1_5
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-38075-4
Online ISBN: 978-3-642-38076-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)