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Pathogenese der Autoimmunpankreatitis

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Erkrankungen des Pankreas

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Zusammenfassung

Die Autoimmunpankreatitis ist eine Sonderform der chronischen Pankreatitis, definiert durch typische klinische Manifestation mit obstruktiver Gelbsucht, gegebenenfalls mit Nachweis einer tumorösen Läsion, gutes therapeutisches Ansprechen auf Steroide und ihr histologisches Bild mit lymphoplasmazellulären Infiltraten und Fibrose. Wenngleich die genauen Mechanismen der Krankheitsentstehung bislang ungeklärt sind, ist von einer Th1-mediierten Entzündungsreaktion auszugehen, die sich gegen Gangstrukturen und Azini richtet, offenbar unter dem Einfluss von unterschiedlichen Autoantikörpern. Prädisponierende genetische Veränderungen wurden beschrieben, ferner scheinen ethnische bzw. regionale Faktoren Einfluss zu nehmen. Analog zu chronischen Pankreatitiden anderer Ursache stellen Autoimmunpankreatitiden einen Risikofaktor für die Entstehung duktaler Pankreaskarzinome dar.

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Authors and Affiliations

  1. Pathologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland

    Frank Bergmann

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  1. Frank Bergmann
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Correspondence to Frank Bergmann .

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Editors and Affiliations

  1. Abt. Allgemeine- und Visceralchirurgie, Universitätsklinikum Ulm, Germany

    Hans G. Beger

  2. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Germany

    Markus W. Büchler

  3. Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Sachsen-Anhalt, Germany

    Henning Dralle

  4. Klinik und Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Germany

    Markus M. Lerch

  5. und Hepatologie (KGHI), Universitätsklinikum Magdeburg, Germany

    Peter Malfertheiner

  6. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Sachsen, Germany

    Joachim Mössner

  7. ehemals Klinikum der Stadt Ludwigshafen gGmbH, Rheinland-Pfalz, Germany

    Jürgen F. Riemann

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Bergmann, F. (2013). Pathogenese der Autoimmunpankreatitis. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_29

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  • DOI: https://doi.org/10.1007/978-3-642-37964-2_29

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37963-5

  • Online ISBN: 978-3-642-37964-2

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