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Ätiologie und Pathogenese der chronischen Pankreatitis

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Erkrankungen des Pankreas

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Zusammenfassung

Ein erhöhter Alkoholkonsum ist für 70–85 % der Fälle verantwortlich und damit mit Abstand die häufigste Ursache der chronischen Pankreatitis (CP). An der idiopathischen CP (20–25 %) sind in annähernd der Hälfte aller Fälle prädisponierende Genmutationen ursächlich beteiligt. Alle anderen Ursachen der CP sind selten. Pathogenetisch ist die CP durch einen Umbau des Organs mit Verlust des funktionellen Parenchyms und Ersatz durch fibrotisches Bindegewebe charakterisiert. Wie es im Rahmen der verschiedenen Ätiologien von der initialen Schädigung zur chronischen Entzündung und zu den genannten Umbauvorgängen kommt, ist weitgehend unbekannt. Im Rahmen des Verlustes von Parenchym kommt es in Abhängigkeit der Erkrankungsdauer zu einer exokrinen und endokrinen Insuffizienz. Im Vordergrund steht für die Patienten allerdings meist eine ausgeprägte lokale Schmerzsymptomatik, die nicht nur durch die lokalen Komplikationen der CP, sondern auch durch eine pankreatische Neuropathie verursacht wird.

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Authors and Affiliations

  1. Chirurgische Klinik, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland

    Oliver Strobel

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  1. Oliver Strobel
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Correspondence to Oliver Strobel .

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Editors and Affiliations

  1. Abt. Allgemeine- und Visceralchirurgie, Universitätsklinikum Ulm, Germany

    Hans G. Beger

  2. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Germany

    Markus W. Büchler

  3. Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Sachsen-Anhalt, Germany

    Henning Dralle

  4. Klinik und Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Germany

    Markus M. Lerch

  5. und Hepatologie (KGHI), Universitätsklinikum Magdeburg, Germany

    Peter Malfertheiner

  6. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Sachsen, Germany

    Joachim Mössner

  7. ehemals Klinikum der Stadt Ludwigshafen gGmbH, Rheinland-Pfalz, Germany

    Jürgen F. Riemann

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Strobel, O. (2013). Ätiologie und Pathogenese der chronischen Pankreatitis. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_15

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  • DOI: https://doi.org/10.1007/978-3-642-37964-2_15

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  • Print ISBN: 978-3-642-37963-5

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