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Pathogenese und Pathophysiologie der akuten Pankreatitis

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Erkrankungen des Pankreas

Zusammenfassung

Die Pankreatitis ist eine primär sterile Entzündung des Pankreas, deren Ursprung in einer vorzeitigen intrazellulären Proteaseaktivierung liegt. Eine wichtige Rolle nimmt hierbei die Serinprotease Trypsin ein. Die pathologische intrazelluläre Proteaseaktivierung führt zu einer ausgedehnten Zellschädigung. Ausgelöst durch den lokalen Zellschaden kommt es zu einer systemischen Immunantwort. Die lokale Immunantwort unterstützt den lokalen pankreatischen Schaden und führt zu einer weiter gesteigerten Aktivierung von Proteasen. Auf der anderen Seite kann die systemische Immunantwort zu einem Multiorganversagen, verbunden mit einer erhöhten Mortalität, führen. Sowohl die lokale als auch die systemische Immunantwort definieren letztendlich den Schweregrad der Erkrankung.

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Authors and Affiliations

  1. Klinik für Innere Medizin A Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Deutschland

    Matthias Sendler & Julia Mayerle

  2. Universitätsmedizin Greifswald Klinik und Poliklinik für Innere Medizin A, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Deutschland

    Markus M. Lerch

Authors
  1. Matthias Sendler
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  2. Julia Mayerle
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  3. Markus M. Lerch
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Correspondence to Matthias Sendler .

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Editors and Affiliations

  1. Abt. Allgemeine- und Visceralchirurgie, Universitätsklinikum Ulm, Germany

    Hans G. Beger

  2. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Germany

    Markus W. Büchler

  3. Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Sachsen-Anhalt, Germany

    Henning Dralle

  4. Klinik und Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Germany

    Markus M. Lerch

  5. und Hepatologie (KGHI), Universitätsklinikum Magdeburg, Germany

    Peter Malfertheiner

  6. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Sachsen, Germany

    Joachim Mössner

  7. ehemals Klinikum der Stadt Ludwigshafen gGmbH, Rheinland-Pfalz, Germany

    Jürgen F. Riemann

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Sendler, M., Mayerle, J., Lerch, M. (2013). Pathogenese und Pathophysiologie der akuten Pankreatitis. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-37964-2_1

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