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Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012) pp 907–912Cite as

Prepared and Characterization of 12β, 15α-Dihydroxy- 16α,17-Epoxyprogesterone

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Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 250))

Abstract

The compound 12β, 15α-dihydroxy-16α, 17-epoxyprogesterone was biotransformed from 16α, 17-epoxyprogesterone by Colletotrichum lini AS3.4486, and its structure was characterized by 1H NMR, 13C NMR, HREI-MS and single-crystal X-ray diffraction. The crystal of the title compound belongs to monoclinic, space group R3 with a = 8.0655(8), b = 12.1955 (12), c = 18.589(2) Å, β = 90°, Z = 4, V = 1828.4(3) Å 3, Dc = 1.309 mg/m3, μ = 0.092 mm−1, F(000) = 776, R = 0.0407 and wR =0.0792. X-ray analysis indicates that intermolecular hydrogen bonds O(2)–H(2)···O(5), O(3)-H(3)···O(2) are observed.

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References

  1. Wu DX, Guan YX, Wang HQ et al (2011) 11a-Hydroxylation of 16 a,17-epoxyprogesterone by Rhizopus nigricans in a biphasic ionic liquid aqueous system. Bioresource Technol 102:9368–9373

    Article  CAS  Google Scholar 

  2. Chen K, Tong WY, Wei DZ et al (2007) The 11β-hydroxylation of 16,17α-epoxyprogesterone and the purification of the 11β-hydroxylase from Absidia coerulea IBL02[J]. Enzyme Microb Tech 41(1/2):71–79

    Article  CAS  Google Scholar 

  3. Shen Y, Sun H, Fu Y et al (2012) Progesterone hydroxylation with Colletotrichum lini AS3. 4486. Adv Mater Res 343–344:1070–1073

    Google Scholar 

  4. Shen YB, Wang M, Liang QK et al (2011) 11a,15a-Dihydroxyandrost-4-ene-3,17-dione. Acta Cryst E67:o2752

    Google Scholar 

  5. Romano A, Romano D, Ragg E et al (2006) Steroid hydroxylations with Botryodiplodia malorum and Colletotrichum lini. Steroids 71:429–434

    Article  CAS  Google Scholar 

  6. Sheldrick GM (2004) SHELX97. University of Göttingen, Germany

    Google Scholar 

  7. Wang S, Wang Y, Nie Q et al (2004) 16a,17-Epoxy-4-pregnene-3,20-dione. Acta Cryst E60:o2337–o2338

    Google Scholar 

  8. Nie Q, Wang JK, Wang S et al (2005) 16a,17-Epoxy-11a-(p-tolylsulfonyloxy)pregn-4- ene-3,20-dione. Acta Cryst E61:o912–o913

    Google Scholar 

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Acknowledgments

This work was supported by the National High Technology Research and Development of China (2011AA02A211), the National Natural Science Foundation of China (Nos. 21076158 and 21276196), and Tianjin City High School Science & Technology Fund Planning Project (20120629).

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Authors and Affiliations

  1. Key Laboratory of Industrial Fermentation Microbiology(Tianjin University of Science and Technology), Ministry of Education; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Yibo Wang, Yanbing Shen, Jiajia Ren, Jianmei Luo & Min Wang

Authors
  1. Yibo Wang
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  2. Yanbing Shen
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  3. Jiajia Ren
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  4. Jianmei Luo
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  5. Min Wang
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Corresponding author

Correspondence to Min Wang .

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Editors and Affiliations

  1. College of Bioengineering ,Tianjin University of Science and Technology, Tianjin, People's Republic of China

    Tong-Cun Zhang

  2. Nanjing University of Technology, Nanjing, People's Republic of China

    Pingkai Ouyang

  3. Department of Microbiology & Molecular Genetics, University of Texas- Houston Medical School, Texas, Texas, USA

    Samuel Kaplan

  4. Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    Bill Skarnes

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© 2014 Springer-Verlag Berlin Heidelberg

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Wang, Y., Shen, Y., Ren, J., Luo, J., Wang, M. (2014). Prepared and Characterization of 12β, 15α-Dihydroxy- 16α,17-Epoxyprogesterone. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 250. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37922-2_97

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  • DOI: https://doi.org/10.1007/978-3-642-37922-2_97

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37921-5

  • Online ISBN: 978-3-642-37922-2

  • eBook Packages: EngineeringEngineering (R0)

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