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Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012) pp 757–764Cite as

Telomerase is Significant as an Early Diagnostic Marker and Therapeutic Target

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Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 250))

Abstract

Breast cancer, a hormone-dependence disease, is the most common malignant tumor in women. Breast cancer incidence rates increase with age. Telomerase is a ribonucleoprotein that maintains chromosome ends and endows cells with unlimited proliferative potential. Activation of telomerase maintains a relatively stable telomere length, confers immortality on some cells, and may even lead to cancer. It has been reported that, in the tissues of the breast, the activity of telomerase can be detected in more than 90 % of invasive breast cancers, while not in adjacent normal tissues. Thus, telomerase activation plays a critical role in development of breast cancer. Telomerase has been proposed as a biomarker with diagnostic and prognostic potential in breast cancer as well as a basis for the targeted therapy of breast cancer.

This work was financially supported by National Natural Science Foundation of China (No.30970615,31071126) and Program for Changjiang Scholars and Innovative Research Team in University Education of China (IRT1166) and the Key Project of Chinese Ministry of Education (212010) and Outstanding Young Talent Project of Scientific Research Plan of Education Department in Hubei province (Q20101111).

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Notes

  1. 1.

    Tong-cun Zhang: E-mail: tony@tust.edu.cn

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Author information

Authors and Affiliations

  1. College of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, People’s Republic of China

    Lian Duan, Xinghua Liao, Jun Zhou, Dalin lu, Jiajie Liu & Tong-Cun Zhang

  2. Key Laboratory of Industrial Microbiology, Ministry of Education and Tianjin City, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Nan Wang, Xinghua Liao, Xueguang Sun & Tong-Cun Zhang

Authors
  1. Lian Duan
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  2. Nan Wang
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  3. Xinghua Liao
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  4. Jun Zhou
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  5. Dalin lu
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  6. Jiajie Liu
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  7. Xueguang Sun
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  8. Tong-Cun Zhang
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Corresponding author

Correspondence to Tong-Cun Zhang .

Editor information

Editors and Affiliations

  1. College of Bioengineering ,Tianjin University of Science and Technology, Tianjin, People's Republic of China

    Tong-Cun Zhang

  2. Nanjing University of Technology, Nanjing, People's Republic of China

    Pingkai Ouyang

  3. Department of Microbiology & Molecular Genetics, University of Texas- Houston Medical School, Texas, Texas, USA

    Samuel Kaplan

  4. Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    Bill Skarnes

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© 2014 Springer-Verlag Berlin Heidelberg

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Duan, L. et al. (2014). Telomerase is Significant as an Early Diagnostic Marker and Therapeutic Target. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 250. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37922-2_78

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  • DOI: https://doi.org/10.1007/978-3-642-37922-2_78

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37921-5

  • Online ISBN: 978-3-642-37922-2

  • eBook Packages: EngineeringEngineering (R0)

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