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Design and Synthesis of 2-Arylbenzimidazole Analogues as Novel SIRT1 Activators for the Treatment of Type II Diabetes

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Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 250))

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Abstract

SIRT1, an NAD+-dependent sirtuin deacetylase, has emerged as potential therapeutic target for treatment of human illnesses such as type II diabetes, cancer, cardiovascular and neurodegenerative diseases. Resveratrol, a naturally occurring small molecule activator of SIRT1, has been demonstrated to improve metabolism and glucose tolerance. SRT1720, an imidazothiazole derivative, recently made as the most potent SIRT1 activator is structurally unrelated to resveratrol. In this work, we design and synthesize a series of compounds as novel potential SIRT1 activators through a two-step convenient synthetic procedure. Fourteen 2-Arylbenzimidazole analogues were characterized on the basis of 1H NMR spectra. Tests for biological activity of these compounds are underway.

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Acknowledgments

Funding for this study was provided by National Natural Science Foundation of China (No: 81072521), Tianjin University of Science & Technology (No: 20100411), International Science & Technology Cooperation Program of China (2013DFA31160) and the Science & Technology Project of Tianjin (11ZCGHHZ00400).

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Authors and Affiliations

  1. Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Fei Hu, Yuanmou Chen, Yinghao Gao, Shaolong Jia, Weizhu Liu, Peng Yu & Erbing Hua

Authors
  1. Fei Hu
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  2. Yuanmou Chen
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  3. Yinghao Gao
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  4. Shaolong Jia
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  5. Weizhu Liu
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  6. Peng Yu
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  7. Erbing Hua
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Corresponding author

Correspondence to Erbing Hua .

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Editors and Affiliations

  1. College of Bioengineering ,Tianjin University of Science and Technology, Tianjin, People's Republic of China

    Tong-Cun Zhang

  2. Nanjing University of Technology, Nanjing, People's Republic of China

    Pingkai Ouyang

  3. Department of Microbiology & Molecular Genetics, University of Texas- Houston Medical School, Texas, Texas, USA

    Samuel Kaplan

  4. Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    Bill Skarnes

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Hu, F. et al. (2014). Design and Synthesis of 2-Arylbenzimidazole Analogues as Novel SIRT1 Activators for the Treatment of Type II Diabetes. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 250. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37922-2_71

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  • DOI: https://doi.org/10.1007/978-3-642-37922-2_71

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37921-5

  • Online ISBN: 978-3-642-37922-2

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