Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Promising Biomarkers: MicroRNAs at Diagnosis, Therapy and Prognostic Evaluation of Breast Cancer

  • Conference paper
  • First Online:
Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 250))

  • 1807 Accesses

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs with regulatory functions, which play an important role in malignancies. An increasing amount of experimental evidence has shown that many miRNAs are aberrantly expressed in breast cancer and influence breast cancer behavior and progression. Furthermore, miRNAs can act either as tumor suppressors or as oncogenes, depending on the targets they regulate, and measurements of miRNAs expression in breast cancer have diagnostic and prognostic implications. Thus, this implies that miRNAs have huge potential as biomarkers. In addition, their extreme stability and ease of detection further support the idea that miRNAs have great potential to evolve into effective biomarkers in the clinic. The objective of this review is to update current realization regarding that miRNAs are promising candidates at diagnostic, therapeutic and prognostic evaluation aspects of clinical application.

D. Lu, X. Liao, and X. Huang contributed equally to this work and are nominated as the first author.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism and function. Cell 116:281–297

    Article  CAS  Google Scholar 

  2. Olsen PH, Ambros V (1999) The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol 216:671–680

    Article  CAS  Google Scholar 

  3. Seggerson K, Tang L, Moss EG (2002) Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev Biol 243: 215–225

    Article  CAS  Google Scholar 

  4. Griffiths-Jones S, Saini HK, van Dongen S et al (2008) miRBase: tools for microRNA genomics. Nucl Acids Res 36:154–158

    Article  Google Scholar 

  5. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20

    Article  CAS  Google Scholar 

  6. Andorfer CA, Necela BM, Thompson EA et al (2011) MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer. Trends in Molecular Medicine 17(6):313–319

    Article  CAS  Google Scholar 

  7. Iorio MV, Ferracin M, Liu CG et al (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65:7065–7070

    Article  CAS  Google Scholar 

  8. Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682–688

    Article  CAS  Google Scholar 

  9. Tavazoie SF, Alarcón C, Oskarsson T et al (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147–152

    Article  CAS  Google Scholar 

  10. Silveri L, Tilly G, Vilotte JL et al (2006) MicroRNA involvement in mammary gland development and breast cancer. Reprod Nutr Dev 46:549–556

    Article  CAS  Google Scholar 

  11. Corcoran C, Friel AM, Duffy MJ et al (2011) Intracellular and Extracellular MicroRNAs in Breast Cancer. Clin Chem 57(1):18–32

    Article  CAS  Google Scholar 

  12. Sempere LF, Christensen M, Silahtaroglu A et al (2007) Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res 67:11612–11620

    Article  CAS  Google Scholar 

  13. Volinia S, Calin GA, Liu CG et al (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. PNAS 103:2257–2261

    Article  CAS  Google Scholar 

  14. Yan LX, Huang XF, Shao Q et al (2008) MicroRNA miR-21 over-expression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 14:2348–2360

    Article  CAS  Google Scholar 

  15. Fassan M, Baffa R, Palazzo JP et al (2009) MicroRNA expression profiling of male breast cancer. Breast Cancer Res 11:R58

    Article  Google Scholar 

  16. Lehmann U, Streichert T, Otto B et al (2010) Identification of differentially expressed microRNAs in human male breast cancer. BMC Cancer 10:109

    Article  Google Scholar 

  17. Heneghan HM, Miller N, Lowery AJ et al (2010) Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg 251:499–505

    Article  Google Scholar 

  18. Selcuklu SD, Donoghue MT, Spillane C (2009) miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans 37:918–925

    Article  CAS  Google Scholar 

  19. Faraoni I, Antonetti FR, Cardone J et al (2009) miR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta 1792(6):497–505

    Article  CAS  Google Scholar 

  20. Wang Y, Lee CG (2009) MicroRNA and cancer: focus on apoptosis. Cell Mol Med 13:12–23

    Article  Google Scholar 

  21. Valastyan S, Reinhardt F, Benaich N et al (2009) A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137(6):1032–1046

    Article  CAS  Google Scholar 

  22. Zhao H, Shen J, Medico L et al (2010) A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS ONE 5(10):e13735

    Article  Google Scholar 

  23. Iguchi H, Kosaka N, Ochiya T (2010) Secretory microRNAs as a versatile communication tool. Commun Integr Biol 3:478–481

    Article  Google Scholar 

  24. Kosaka N, Iguchi H, Ochiya T (2010) Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 101:2087–2092

    Article  CAS  Google Scholar 

  25. Kosaka N, Iguchi H, Yoshioka Y et al (2010) Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285:17442–17452

    Article  CAS  Google Scholar 

  26. Mattie MD, Benz CC, Bowers J et al (2006) Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer 5:24

    Article  Google Scholar 

  27. Blenkiron C, Goldstein LD, Thorne NP et al (2007) MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol 8:R214

    Article  Google Scholar 

  28. Zhu S, Wu H, Wu F et al (2008) MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18:350–359

    Article  CAS  Google Scholar 

  29. Bhaumik D, Scott GK, Schokrpur S et al (2008) Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27:5643–5647

    Article  CAS  Google Scholar 

  30. Scott GK, Goga A, Bhaumik D et al (2007) Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 282:1479–1486

    Article  CAS  Google Scholar 

  31. Adams BD, Furneaux H, White BA (2007) The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha(ERα) and represses ERα messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21:1132–1147

    Article  CAS  Google Scholar 

  32. Lu J, Getz G, Miska EA et al (2005) MicroRNA expression profiles classify human cancers. Nature 435:834–838

    Article  CAS  Google Scholar 

  33. Zhao JJ, Lin J, Yan H et al (2008) miRNA-221/222 negatively regulates estrogen receptor and is associated with tamoxifen resistance in breast cancer. J Biol Chem 283(45):31079–31086

    Article  CAS  Google Scholar 

  34. Qi L, Bart J, Tan LP et al (2009) Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma.BMC Cancer 9:163

    Article  Google Scholar 

  35. Huang GL, Zhang XH, Guo GL et al (2008) Expression of microRNA-21 in invasive ductal carcinoma of the breast and its association with phosphatase and tensin homolog deleted from chromosome expression and clinicopathologic features. Zhonghua Yi Xue Za Zhi 88:2833–2837

    CAS  Google Scholar 

  36. Qian B, Katsaros D, Lu L et al (2009) High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. Breast Cancer Res Treat 117:131–140

    Article  CAS  Google Scholar 

  37. Song B, Wang C, Liu J et al (2010) MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res 29:29

    Article  CAS  Google Scholar 

  38. Huang TH, Wu F, Loeb GB et al (2009) Up-regulation of mir-21 by her2/neu signaling promotes cell invasion. J Biol Chem 284:18515–18524

    Article  CAS  Google Scholar 

  39. Kong W, He L, Coppola M et al (2010) MicroRNA-155 regulates cell survival, growth, and chemo-sensitivity by targeting FOXO3a in breast cancer. J Biol Chem 285:17869–17879

    Article  CAS  Google Scholar 

  40. Jiang S, Zhang HW, Lu MH et al (2010) MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res 70:3119–3127

    Article  CAS  Google Scholar 

  41. Kong W, Yang H, He L et al (2008) MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28:6773–6784

    Article  CAS  Google Scholar 

  42. Ovcharenko D, Kelnar K, Johnson C et al (2007) Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of trail-induced apoptosis pathway. Cancer Res 67:10782–10788

    Article  CAS  Google Scholar 

  43. Hui AB, Shi W, Boutros PC et al (2009) Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest 89:597–606

    Article  CAS  Google Scholar 

  44. Luthra R, Singh RR, Luthra MG et al (2008) MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 down-regulation in cancers. Oncogene 27:6667–6678

    Article  CAS  Google Scholar 

  45. Ma L, Reinhardt F, Pan E et al (2010) Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 28:341–347

    Article  CAS  Google Scholar 

  46. Moriarty CH, Pursell B, Mercurio AM (2010) miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem 285:20541–20546

    Article  CAS  Google Scholar 

  47. Esquela-Kerscher A, Slack FJ (2006) Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6:259–269

    Article  CAS  Google Scholar 

  48. Navon R, Wang H, Steinfeld I et al (2009) Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS ONE 4(11):e8003

    Article  Google Scholar 

  49. Zhou M, Liu Z, Zhao Y et al (2010) MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem 285:21496–21507

    Article  CAS  Google Scholar 

  50. Hofmann MH, Heinrich J, Radziwill G et al (2009) A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. Mol Cancer Res 7:1635–1644

    Article  CAS  Google Scholar 

  51. Spizzo R, Nicoloso MS, Lupini L et al (2010) miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-α in human breast cancer cells. Cell Death Differ 17:246–254

    Article  CAS  Google Scholar 

  52. Sachdeva M, Zhu S, Wu F et al (2009) p53 represses c-Myc through induction of the tumor suppressor miR-145. PNAS 106(9):3207–3212

    Article  CAS  Google Scholar 

  53. Sachdeva M, Mo YY (2010) MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. Cancer Res 70:378–387

    Article  CAS  Google Scholar 

  54. Wang S, Bian C, Yang Z et al (2009) miR-145 inhibits breast cancer cell growth through RTKN. Int J Oncol 34:1461–1466

    CAS  Google Scholar 

  55. Wu H, Zhu S, Mo YY (2009) Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res 19:439–448

    Article  CAS  Google Scholar 

  56. Gregory PA, Bert AG, Paterson EL et al (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10:593–601

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was financially supported by National Natural Science Foundation of China (No. 30970615, 31071126) and Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (IRT1166) and the Key Project of Chinese Ministry of Education (212010) and Hubei key project of Science and Technology Research (No. D20111102) and Hubei Natural Science Foundation (No.2010CDB03506).

Author information

Authors and Affiliations

  1. Medical school, Wuhan University of Science and Technology, Wuhan, 430000, People’s Republic of China

    Dalin Lu, Xinghua Liao, Zhenyu Wang, Lian Duan, Jiajie Liu & Tong-Cun Zhang

  2. Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education and Tianjin, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Dalin Lu, Nan Wang, Xinghua Liao, Yue Wang & Tong-Cun Zhang

  3. The Second Artillery General Hospital PLA, Beijing, 100000, People’s Republic of China

    Dalin Lu, Jianhua Zhang & Baoshu Jin

  4. Medical School, Nanchang University, Nanchang, 330006, People’s Republic of China

    Xuan Huang

Authors
  1. Dalin Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xinghua Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xuan Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jianhua Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Zhenyu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lian Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jiajie Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Baoshu Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yue Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Tong-Cun Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tong-Cun Zhang .

Editor information

Editors and Affiliations

  1. College of Bioengineering ,Tianjin University of Science and Technology, Tianjin, People's Republic of China

    Tong-Cun Zhang

  2. Nanjing University of Technology, Nanjing, People's Republic of China

    Pingkai Ouyang

  3. Department of Microbiology & Molecular Genetics, University of Texas- Houston Medical School, Texas, Texas, USA

    Samuel Kaplan

  4. Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    Bill Skarnes

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lu, D. et al. (2014). Promising Biomarkers: MicroRNAs at Diagnosis, Therapy and Prognostic Evaluation of Breast Cancer. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 250. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37922-2_66

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-37922-2_66

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37921-5

  • Online ISBN: 978-3-642-37922-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation