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Anionic Cyclodextrins for Capillary Electrophoresis

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Modified Cyclodextrins for Chiral Separation

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Abstract

An overview of negatively charged (anionic) cyclodextrins for enantiomeric separation using capillary electrophoresis (CE) is presented. Starting from commercially available multisubstituted anionic cyclodextrins, this chapter gives an updated summary of single-isomer anionic CDs for chiral CE. The correlation of cyclodextrins structure and their enantioselectivities, as well as the optimization of analytical parameters for enantiomeric separation with these cyclodextrins, are discussed.

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Abbreviations

CE:

Capillary electrophoresis

CD:

Cyclodextrin

CEKC:

Capillary electrokinetic chromatography

EOF:

Electroosmotic flow

SBE-β-CD:

Sulfobutyl ether β-CD

CM-β-CD:

Carboxymethyl-β-CD

SEE-β-CD:

Sulfoethyl ether β-CD

S-β-CD:

Sulfated β-cyclodextrin

CZE:

Capillary zone electrophoresis

HP-β-CD:

2-Hydroxypropyl-β-cyclodextrin

LPME:

Liquid-phase microextraction

DCIT:

Desmethylcitalopram

PPF:

Propafenone

5OH-PPF:

5-Hydroxy-propafenone

NOR-PPF:

N-despropyl-propafenone

CE-β-CD:

Carboxyethylated β-CD

DHPs:

1,4-Dihydropyridines

CM-γ-CD:

Carboxymethyl-γ-CD

Su-β-CD:

Succinylated β-CD

THP:

Trihexyphenidyl

M-β-CD:

Methylated β-cyclodextrin

DM-β-CD:

Heptakis(2,6-di-O-methyl)-β-cyclodextrin

SBE-γ-CD:

Sulfobutyl ether γ-CD

DOPA:

Dihydroxyphenylalanine

MDOPA:

Methyldihydroxyphenylalanine

CDOPA:

Hydrazinomethyldihydroxyphenylalanine

HDAS β-CD:

Heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin

HP-γ-CD:

Hydroxypropyl-γ-CD

HxS-α-CD:

Hexakis(6-O-sulfo)-α-cyclodextrin

HS-β-CD:

Hepta-6-sulfato-β-cyclodextrin

OS-γ-CD:

Octa(6-O-sulfo)-γ-cyclodextrin

HDMS-β-CD:

Heptakis(2,3-dimethyl-6-sulfato)-β-cyclodextrin

HxDAS-α-CD:

Hexakis(2,3-di-O-acetyl-6-O-sulfo)-α-CD

ODAS-γ-CD:

Octakis(2,3-diacetyl-6-sulfato)-γ-cyclodextrin

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  1. Key Laboratory of Soft Chemistry and Functional Materials (Ministry of Education of China), Nanjing University of Science and Technology, Nanjing, 210094, People’s Republic of China

    Shuye Wang, Jiefeng Hai & Weihua Tang

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  1. Shuye Wang
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  2. Jiefeng Hai
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  1. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Weihua Tang

  2. , School of Chemical and Biomedical, Nanyang Technological University, Nanyang Drive 62, Singapore, 637459, Singapore

    Siu-Choon Ng

  3. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Dongping Sun

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Wang, S., Hai, J., Tang, W. (2013). Anionic Cyclodextrins for Capillary Electrophoresis. In: Tang, W., Ng, SC., Sun, D. (eds) Modified Cyclodextrins for Chiral Separation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37648-1_6

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