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Modified Cyclodextrins for Chiral Separation pp 27–66Cite as

Cyclodextrin-Based Chiral Stationary Phases for Gas Chromatography

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Abstract

In this chapter, cyclodextrin-based chiral stationary phases (CSPs) developed for the enantiomeric separation using gas chromatography are reviewed. A correlation of the CD structure and the enantioselectivities of the resultant CSPs are discussed.

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Abbreviations

GC:

Gas chromatography

GC-MS:

Gas chromatography

HPLC:

High-performance liquid chromatography

SFC:

Supercritical fluid chromatography

FID:

Flame ionization detection

CSP:

Chiral stationary phase

CD:

Cyclodextrin

CMP:

Chiral mobile phase additives

Chiraldex PH-A:

Permethylated S-hydroxypropyl-α-CD

Chiraldex PH-B:

Permethylated S-hydroxypropyl-β-CD

Chiraldex PH-G:

Permethylated S-hydroxypropyl-γ-CD

Chiraldex DA-A:

2,6-O-Dipentylated 3-O-acetylated α-CD

Chiraldex DA-B:

2,6-O-Dipentylated 3-O-acetylated β-CD

Chiraldex DA-G:

2,6-O-Dipentylated 3-O-acetylated γ-CD

Chiraldex TA-A:

2,6-O-Dipentylated 3-O-trifluoroacetylated α-CD

Chiraldex TA-B:

2,6-O-Dipentylated 3-O-trifluoroacetylated β-CD

Chiraldex TA-G:

2,6-O-Dipentylated 3-O-trifluoroacetylated γ-CD

Chiraldex PN-G:

2,6-O-Dipentylated 3-O-propionyl-γ-CD

Chiraldex BP-G:

2,6-O-Dipentylated 3-O-butyryl-γ-CD

Chiraldex DM-B:

Di-O-dimethyl-β-CD

Hydrodex B:

Permethylated β-CD + polysiloxane

Chiraldex B:

Permethylated β-CD + poly(dimethylsi1oxane)

Lipodex A:

2,3,6-Tri-O-pentyl-α-CD

Lipodex B:

2,3,6-Tri-O-pentyl-3-O-acetyl-α-CD

Lipodex C:

2,3,6-Tri-O-pentyl-β-CD

Lipodex D:

2,3,6-Tri-O-pentyl-3-O-acetyl-β-CD

Lipodex E:

2,3,6-Tri-O-pentyl-3-O-acetyl-γ-CD

α-Dex 120:

Permethylated α-CD (20 %)-SPB 35

β-Dex 110:

Permethylated β-CD (20 %)-SPB 35

β-Dex 120:

Permethylated γ-CD (20 %)-SPB 35

perMe-β-CD:

2,3,6-Permethyl-β-cyclodextrin

perMe-γ-CD:

2,3,6-Permethyl-γ-cyclodextrin

DMP-B:

2,6-Di-O-methyl-3-O-pentyl-β-cyclodextrin

DMP-G:

2,6-Di-O-methyl-3-O-pentyl-γ-cyclodextrin

CP-Chirasil-Dex CB:

Heptakis(2,3,6-tri-O-metil)-β-cyclodextrin

OPP:

Organophosphorus pesticide

PMHP-α-CD:

Permethyl-O-(S)-2-hydroxypropyl-α-cyclodextrin

PMHP-β-CD:

Permethyl-O-(S)-2-hydroxypropyl-β-cyclodextrin

PMHP-γ-CD:

Permethyl-O-(S)-2-hydroxypropyl-γ-cyclodextrin

DBTBCD:

Heptakis(2,6-di-O-butyl- 3-O-trifluoroacetyl)-β-CD

DNTBCD:

Heptakis(2,6-di-O-nonyl-3-O-trifluoroacetyl)-β-CD

DDTBCD:

Heptakis(2,6-di-O-dodecyl-3-O-trifluoroacetyl)-β-CD

DBBBCD:

Heptakis(2,6-di-O-butyl-3-O-butyryl)-β-CD

DPABCD:

Heptakis(2,6-di-O-pentyl-3-O-acetyl)-β-CD

20Me/P6COOMe:

6I-O-Methoxy-carbonyl-6I-deoxy-2I–VII,3I–VII,6II–VIIeicosa-O-methylcyclodextrin

20Me/P6OCH2CO OMe:

6I-O-Methoxycarbonylmethyl-2I–VII,3I–VII,6II–VII-eicosa-O -methyl-cyclodextrin

20Me/P2OCH2COOMe:

2I-O-Methoxycarbonylmethyl-2II–VII, 3I–VII,6I–VII-eicosa-O-methyl-cyclodextrin

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Authors and Affiliations

  1. Key Laboratory of Soft Chemistry and Functional Materials (Ministry of Education of China), Nanjing University of Science and Technology, Nanjing, 210094, People’s Republic of China

    Yun Dai, Jiefeng Hai & Weihua Tang

  2. Division of Chemical and Biomolecular Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore

    Siu-Choon Ng

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  1. Yun Dai
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  2. Jiefeng Hai
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  3. Weihua Tang
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  4. Siu-Choon Ng
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Correspondence to Weihua Tang .

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Editors and Affiliations

  1. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Weihua Tang

  2. , School of Chemical and Biomedical, Nanyang Technological University, Nanyang Drive 62, Singapore, 637459, Singapore

    Siu-Choon Ng

  3. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Dongping Sun

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Dai, Y., Hai, J., Tang, W., Ng, SC. (2013). Cyclodextrin-Based Chiral Stationary Phases for Gas Chromatography. In: Tang, W., Ng, SC., Sun, D. (eds) Modified Cyclodextrins for Chiral Separation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37648-1_2

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