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Nanoparticle and Protein Corona

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Protein-Nanoparticle Interactions

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 15))

Abstract

Nanoparticles and other nanomaterials are increasingly considered for use in biomedical applications such as imaging, drug delivery, and hyperthermic therapies. Thus, understanding the interaction of nanomaterials with biological systems becomes key for their safe and efficient application. It is increasingly being accepted that the surface of nanomaterials would be covered by protein corona upon their entrance to the biological medium. The biological medium will then see the achieved modified surface of nanomaterials, and therefore further cellular/tissue responses depend on the composition of corona. In this chapter, we describe the corona variations according to the physicochemical properties of nanomaterials (e.g., size, shape, surface charge, surface functional groups, and hydrophilicity/hydrophobicity). Besides the nanomaterials’ effects, the role of environment factors, such as protein source and slight temperature variations, is discussed in details.

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering and Materials Science, University of California in Davis, Davis, California, USA

    Masoud Rahman

  2. NanoBio Interactions Laboratory Department of Nanotechnology Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Sophie Laurent

  3. Laboratoire d’Innovation et, d’Analyse de Bioperformance, École Polytechnique de Montréal, Montreal, Québec, Canada

    Nancy Tawil & L’Hocine Yahia

  4. Pasteur Institute of Iran, National Cell Bank NanoBio Interactions Laboratory, Tehran, Iran

    Morteza Mahmoudi

Authors
  1. Masoud Rahman
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  2. Sophie Laurent
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  3. Nancy Tawil
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  4. L’Hocine Yahia
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  5. Morteza Mahmoudi
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Rahman, M., Laurent, S., Tawil, N., Yahia, L., Mahmoudi, M. (2013). Nanoparticle and Protein Corona. In: Protein-Nanoparticle Interactions. Springer Series in Biophysics, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37555-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-37555-2_2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37554-5

  • Online ISBN: 978-3-642-37555-2

  • eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)

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