Abstract
In the recent decade, the fabrication of nanoparticles and exploration of their properties have attracted the attention of all branches of science such as physicists, chemists, biologists, engineers, and even medical doctors. Interests for nanoparticles arise from the fact that their mechanical, chemical, electrical, optical, magnetic, electro-optical, and magneto-optical properties of these nanoparticles are completely different from their bulk properties and the predetermined differences are depended on the physicochemical properties of the nanoparticles. There are numerous areas where nanoparticles are of scientific and technological interest, specifically for medical community, where the synthetic and biologic worlds come together and lead to an important concern for design of safe nano-biomaterials. In this chapter, we review and discuss the major biomedical applications of nanoparticles.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Berube D, Bormand PJA (2008) A tale of opportunities, uncertainties and risks. Nanotoday 3:56–59
Roco MC, Harthorn B, Guston D, Shapira P (2011) Innovative and responsible governance of nanotechnology for societal development. J Nanopart Res 13:3557–3590
Roco MC, Mirkin CA, Hersam MC (2011) Nanotechnology research directions for societal needs in 2020: summary of international study. J Nanopart Res 13:897–919
Roco MC (2011) Nanotechnology: from discovery to innovation and socioeconomic projects. Chem Eng Prog 107:21–27
Canadian Institute of Health Research (2011) Important funding for nanomedicine research to improve diagnosis and treatment, vol 2011. Canadian Institute of Health Research, Ottawa
Comeau AM, Bertrand C, Letarov A, Tetart F, Krisch HM (2007) Modular architecture of the T4 phage superfamily: a conserved core genome and a plastic periphery. Virology 362:384–396
Juanola-Feliu E, Colomer-Farrarons J, Miribel-Catala P, Samitier J, Valls-Pasola J (2012) Market challenges facing academic research in commercializing nano-enabled implantable devices for in-vivo biomedical analysis. Technovation 32:193–204
Shapira P, Wang J (2010) Follow the money. Nature 468:627–628
Clavijo-Jordan V, Kodibagkar VD, Beeman SC, Hann BD, Bennett KM (2012) Principles and emerging applications of nanomagnetic materials in medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:345–365
Xu C, Mu L, Roes I, Miranda-Nieves D, Nahrendorf M, Ankrum JA, Zhao W, Karp JM (2011) Nanoparticle-based monitoring of cell therapy. Nanotechnology 22:494001
Jain RK, Stylianopoulos T (2010) Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 7:653–664
Lee JH, Jang JT, Choi JS, Moon SH, Noh SH, Kim JW, Kim JG, Kim IS, Park KI, Cheon J (2011) Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol 6:418–422
Rogers WJ, Meyer CH, Kramer CM (2006) Technology insight: in vivo cell tracking by use of MRI. Nat Clin Pract Cardiovasc Med 3:554–562
Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan CW, Mellinghoff IK, Holland EC, Gambhir SS (2012) A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nat Med 18:829–834
Jin Y, Jia C, Huang SW, O’Donnell M, Gao X (2010) Multifunctional nanoparticles as coupled contrast agents. Nat Commun 1:41
Tawil N, Sacher E, Mandeville R, Meunier M (2012) Surface plasmon resonance detection of E. coli and methicillin-resistant S. aureus using bacteriophages. Biosens Bioelectron 37:24–29
Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR (2010) Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol 7:266–276
Martel S, Mathieu JB, Felfoul O, Chanu A, Aboussouan E, Tamaz S, Pouponneau P, Yahia L, Beaudoin G, Soulez G, Mankiewicz M (2007) Medical and technical protocol for automatic navigation of a wireless device in the carotid artery of a living swine using a standard clinical MRI system. In: Ayache N, Ourselin S, Maeder A (eds) Medical image computing and computer-assisted intervention – MICCAI 2007, Pt 1, Proceedings, vol 4791, 29 October to 2 November, Brisbane, Australia, pp 144–152
Kostarelos K, Bianco A, Prato M (2009) Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 4:627–633
Polizu S, Maugey M, Poulin S, Poulin P, Yahia L (2006) Nanoscale surface of carbon nanotube fibers for medical applications: structure and chemistry revealed by TOF-SIMS analysis. Appl Surf Sci 252:6750–6753
Polizu S, Savadogo O, Poulin P, Yahia L (2006) Applications of carbon nanotubes-based biomaterials in biomedical nanotechnology. J Nanosci Nanotechnol 6:1883–1904
Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9:615–627
Craighead H (2006) Future lab-on-a-chip technologies for interrogating individual molecules. Nature 442:387–393
He G, Eckert J, Loser W, Schultz L (2003) Novel Ti-base nanostructure-dendrite composite with enhanced plasticity. Nat Mater 2:33–37
Balandin AA (2011) Thermal properties of graphene and nanostructured carbon materials. Nat Mater 10:569–581
Tan SJ, Campolongo MJ, Luo D, Cheng W (2011) Building plasmonic nanostructures with DNA. Nat Nanotechnol 6:268–276
Linic S, Christopher P, Ingram DB (2011) Plasmonic-metal nanostructures for efficient conversion of solar to chemical energy. Nat Mater 10:911–921
Tao NJ (2006) Electron transport in molecular junctions. Nat Nanotechnol 1:173–181
Scholl JA, Koh AL, Dionne JA (2012) Quantum plasmon resonances of individual metallic nanoparticles. Nature 483:421–427
Pickup JC (2012) Management of diabetes mellitus: is the pump mightier than the pen? Nat Rev Endocrinol 8:425–433
Xiang Y, Lu Y (2011) Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets. Nat Chem 3:697–703
Barone PW, Baik S, Heller DA, Strano MS (2005) Near-infrared optical sensors based on single-walled carbon nanotubes. Nat Mater 4:86–92
Cash KJ, Clark HA (2010) Nanosensors and nanomaterials for monitoring glucose in diabetes. Trends Mol Med 16:584–593
Receveur RAM, Lindemans FW, de Rooij NF (2007) Microsystem technologies for implantable applications. J Micromech Microeng 17:R50–R80
Wu CS, Khaing Oo MK, Fan X (2010) Highly sensitive multiplexed heavy metal detection using quantum-dot-labeled DNAzymes. ACS Nano 4:5897–5904
Keefer EW, Botterman BR, Romero MI, Rossi AF, Gross GW (2008) Carbon nanotube coating improves neuronal recordings. Nat Nanotechnol 3:434–439
El-Hosseiny A, Genaidy A, Shell R, Stambough JL, Dimov M (2008) Multinetwork nanobiosensing: potential approaches in understanding, diagnosing, and tracking discogenic pain. Human Factors Ergon Manuf 18:374–390
Ryu WH, Vyakarnam M, Greco RS, Prinz FB, Fasching RJ (2007) Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers. Biomed Microdev 9:845–853
Qiu HJ, Li L, Lang QL, Zou FX, Huang XR (2012) Aligned nanoporous PtNi nanorod-like structures for electrocatalysis and biosensing. RSC Adv 2:3548–3554
Qiu H, Zou F (2012) Fabrication of stratified nanoporous gold for enhanced biosensing. Biosens Bioelectron 35:349–354
Kauffman DR, Shade CM, Uh H, Petoud S, Star A (2009) Decorated carbon nanotubes with unique oxygen sensitivity. Nat Chem 1:500–506
Kabashin AV, Evans P, Pastkovsky S, Hendren W, Wurtz GA, Atkinson R, Pollard R, Podolskiy VA, Zayats AV (2009) Plasmonic nanorod metamaterials for biosensing. Nat Mater 8:867–871
Zijlstra P, Paulo PM, Orrit M (2012) Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod. Nat Nanotechnol 7:379–382
Xie P, Xiong Q, Fang Y, Qing Q, Lieber CM (2012) Local electrical potential detection of DNA by nanowire-nanopore sensors. Nat Nanotechnol 7:119–125
Scarpa G, Idzko AL, Yadav A, Martin E, Thalhammer S (2010) Toward cheap disposable sensing devices for biological assays. IEEE Trans Nanotechnol 9:527–532
Kolmakov A, Moskovits M (2004) Chemical sensing and catalysis by one-dimensional metal-oxide nanostructures. Annu Rev Mater Res 34:151–180
Bondavalli P, Legagneux P, Pribat D (2009) Carbon nanotubes based transistors as gas sensors: state of the art and critical review. Sens Actuator B-Chem 140:304–318
Vichchulada P, Lipscomb LD, Zhang QH, Lay MD (2009) Incorporation of single-walled carbon nanotubes into functional sensor applications. J Nanosci Nanotechnol 9:2189–2200
Cho SH, Chang WS, Kim KR, Hong JW (2009) Measurement of UV absorption of single living cell for cell manipulation using NIR femtosecond laser. Appl Surf Sci 255:4974–4978
Ronchi P, Terjung S, Pepperkok R (2012) At the cutting edge: applications and perspectives of laser nanosurgery in cell biology. Biol Chem 393:235–248
Winkler MT, Sher MJ, Lin YT, Smith MJ, Zhang HF, Gradecak S, Mazur E (2012) Studying femtosecond-laser hyperdoping by controlling surface morphology. J Appl Phys 111:093511
Watanabe W, Matsunaga S, Higashi T, Fukui K, Itoh K (2008) In vivo manipulation of fluorescently labeled organelles in living cells by multiphoton excitation. J Biomed Opt 13:031213
Brugues J, Nuzzo V, Mazur E, Needleman DJ (2012) Nucleation and transport organize microtubules in metaphase spindles. Cell 149:554–564
Reich U, Fadeeva E, Warnecke A, Paasche G, Muller P, Chichkov B, Stover T, Lenarz T, Reuter G (2012) Directing neuronal cell growth on implant material surfaces by microstructuring. J Biomed Mater Res Part B Appl Biomater 100:940–947
Baumgart J, Humbert L, Boulais E, Lachaine R, Lebrun JJ, Meunier M (2012) Off-resonance plasmonic enhanced femtosecond laser optoporation and transfection of cancer cells. Biomaterials 33:2345–2350
Bath J, Turberfield AJ (2007) DNA nanomachines. Nat Nanotechnol 2:275–284
Wendell D, Jing P, Geng J, Subramaniam V, Lee TJ, Montemagno C, Guo P (2009) Translocation of double-stranded DNA through membrane-adapted phi29 motor protein nanopores. Nat Nanotechnol 4:765–772
Baraban L, Makarov D, Streubel R, Monch I, Grimm D, Sanchez S, Schmidt OG (2012) Catalytic Janus motors on microfluidic chip: deterministic motion for targeted cargo delivery. ACS Nano 6:3383–3389
Gao W, Sattayasamitsathit S, Wang J (2012) Catalytically propelled micro-/nanomotors: how fast can they move? Chem Rec 12:224–231
Solovev AA, Xi W, Gracias DH, Harazim SM, Deneke C, Sanchez S, Schmidt OG (2012) Self-propelled nanotools. ACS Nano 6:1751–1756
Pumera M (2010) Electrochemically powered self-propelled electrophoretic nanosubmarines. Nanoscale 2:1643–1649
Wang J, Manesh KM (2010) Motion control at the nanoscale. Small 6:338–345
Han SW, Nakamura C, Obataya I, Nakamura N, Miyake J (2005) A molecular delivery system by using AFM and nanoneedle. Biosens Bioelectron 20:2120–2125
Obataya I, Nakamura C, Han S, Nakamura N, Miyake J (2005) Nanoscale operation of a living cell using an atomic force microscope with a nanoneedle. Nano Lett 5:27–30
Chen X, Kis A, Zettl A, Bertozzi CR (2007) A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci USA 104:8218–8222
Singhal R, Orynbayeva Z, Kalyana Sundaram RV, Niu JJ, Bhattacharyya S, Vitol EA, Schrlau MG, Papazoglou ES, Friedman G, Gogotsi Y (2011) Multifunctional carbon-nanotube cellular endoscopes. Nat Nanotechnol 6:57–64
Lutolf MP, Hubbell JA (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23:47–55
Orive G, Anitua E, Pedraz JL, Emerich DF (2009) Biomaterials for promoting brain protection, repair and regeneration. Nat Rev Neurosci 10:682–692
Grafahrend D, Heffels KH, Beer MV, Gasteier P, Moller M, Boehm G, Dalton PD, Groll J (2011) Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. Nat Mater 10:67–73
Amir-Aslani A, Mangematin V (2010) The future of drug discovery and development: shifting emphasis towards personalized medicine. Technol Forecast Soc Change 77:203–217
Martel S, Mohammadi M, Felfoul O, Lu Z, Pouponneau P (2009) Flagellated magnetotactic bacteria as controlled MRI-trackable propulsion and steering systems for medical nanorobots operating in the human microvasculature. Int J Robot Res 28:571–582
Zderic V, Clark JI, Martin RW, Vaezy S (2004) Ultrasound-enhanced transcorneal drug delivery. Cornea 23:804–811
Yanga W, Peters JI, Williams RO III (2008) Inhaled nanoparticles—a current review. Int J Pharm 356:239–247
Ghosh Chaudhuri R, Paria S (2012) Core/shell nanoparticles: classes, properties, synthesis mechanisms, characterization, and applications. Chem Rev 112:2373–2433
Powers KW, Brown SC, Krishna VB, Wasdo SC, Moudgil BM, Roberts SM (2006) Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90:296–303
Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–557
Kuna JJ, Voitchovsky K, Singh C, Jiang H, Mwenifumbo S, Ghorai PK, Stevens MM, Glotzer SC, Stellacci F (2009) The effect of nanometre-scale structure on interfacial energy. Nat Mater 8:837–842
Monopoli MP, Aberg C, Salvati A, Dawson KA (2012) Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol 7:779–786
Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. Nanotoday 3:40–47
Salata O (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:3
Gaumet M, Vargas A, Gurny R, Delie F (2008) Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur J Pharm Biopharm 69:1–9
Chellata F, Merhi Y, Moreau A, Yahia LH (2005) Therapeutic potential of nanoparticulate systems for macrophage targeting. Biomaterials 26:7260–7275
Sun C, Lee JS, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252–1265
Breunig M, Bauer S, Goepferich A (2008) Polymers and nanoparticles: intelligent tools for intracellular targeting? Eur J Pharm Biopharm 68:112–128
Mbeh DA, Franca R, Merhi Y, Zhang XF, Veres T, Sacher E, Yahia L (2012) In vitro biocompatibility assessment of functionalized magnetite nanoparticles: biological and cytotoxicological effects. J Biomed Mater Res Part A 100:1637–1646
Nel A, Xia T, Mädler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622
Li N, Xia T, Nel AE (2008) The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44:1689–1699
Huang YW, Wu CH, Aronstam RS (2010) Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials 3:4842–4859
Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V (2010) A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physico-chemical characteristics. Nanotoxicology 4:207–246
Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA, Syed AF (2010) Metal-based nanoparticles and their toxicity assessment. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:544–568
Unfried K, Albrecht C, Klotz LO, Von Mikecz A, Grether-Beck S, Schins RPF (2007) Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1:52–71
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Rahman, M., Laurent, S., Tawil, N., Yahia, L., Mahmoudi, M. (2013). The Biological Significance of “Nano”-interactions. In: Protein-Nanoparticle Interactions. Springer Series in Biophysics, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37555-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-37555-2_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-37554-5
Online ISBN: 978-3-642-37555-2
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)