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Mucus, Goblet Cell, Submucosal Gland

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Nasal Physiology and Pathophysiology of Nasal Disorders

Abstract

Airway mucus blankets all mucosal surfaces, providing a physicochemical barrier that protects underlying epithelium against bacteria, viruses, and inhaled particles and gases. Mucus maintains airway hydration and plays an important role in the innate immune system by trapping foreign and endogenous substances, facilitating clearance by mucociliary activity. Mucus also has antioxidant, antiprotease, and antimicrobial functions. Composed of water, ions, serum protein exudates, epithelial secretions, and glandular and goblet cell products, mucus contains various defensive components such as glycoproteins (mucins), antibodies, defensin, lysozyme, and lactoferrin.

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Abbreviations

AP-1:

Activated protein-1

AR:

Allergic rhinitis

AZM:

Azithromycin

CAM:

Clarithromycin

CF:

Cystic fibrosis

CREB:

cAMP response element binding protein

CRS:

Chronic rhinosinusitis

cysLTs:

Cysteinyl leukotrienes

EGFR:

Epidermal growth factor receptor

EM:

Erythromycin

Foxa2:

Forkhead box a2

IL:

Interleukin

NF-κB:

Nuclear factor κ-B

RA:

Retinoic acid

STAT6:

Signal transducer and activator of transcription 6

TGF:

Transforming growth factor

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan

    Takeshi Shimizu MD

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  1. Dept. of Otorhinolaryngology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    T. Metin Önerci

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Shimizu, T. (2013). Mucus, Goblet Cell, Submucosal Gland. In: Önerci, T. (eds) Nasal Physiology and Pathophysiology of Nasal Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37250-6_1

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