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B-Lymphozyten und der Antikörperklassenwechsel zu IgE

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Allergologie

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Zusammenfassung

B-Zellen entwickeln sich im Knochenmark aus hämatopoetischen Vorläuferzellen. Sie produzieren Antikörper, die zentrale Elemente des humoralen Immunsystems sind. Die Antikörper der Klassen IgM, IgD, IgG, IgA und IgE werden über verschiedene konstante Regionen in ihren schweren Ketten definiert. Sie zeigen eine unterschiedliche Gewebeverteilung und Wirkung auf Pathogene. Der Klassenwechsel entsteht durch einen Austausch der exprimierten schweren Kettencluster, z. B. von C-µ für IgM mit C-γ, C-α oder C-ε, sodass dementsprechend IgG, IgA oder IgE entsteht, wobei die antigenbindende variable Region nicht verändert wird. Die Induktion des Klassenwechsels benötigt primäre und sekundäre Signale. Signale, die einen primären Klassenwechsel induzieren, vermitteln die Expression der »activation induced cytidine deaminase« (AID) und weitere Proteine, die für den Klassenwechsel eine Rolle spielen, wie etwa den Transkriptionsfaktor NF-κΒ. Signale, die sekundär einen Klassenwechsel fördern, können die Expression von AID nicht induzieren, sind jedoch für die Steuerung des Klassenwechsels zu einem bestimmten Isotyp, wie bspw. IgG, IgA oder IgE durch die Auswahl der S-Region über die Induktion der Keimwandtranskripte, wirksam. Für IgE spielen hier die Zytokine IL-4 und IL-13 beim Menschen eine zentrale Rolle.

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Authors and Affiliations

  1. Institut der Leibniz-Gemeinschaft, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Charitéplatz 1, 10117, Berlin, Deutschland

    A. Radbruch Prof. Dr. rer. nat.

  2. Klinik für Dermatologie, Venerologie und Allergologie, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    M. Worm Prof. Dr. med.

Authors
  1. A. Radbruch Prof. Dr. rer. nat.
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  2. M. Worm Prof. Dr. med.
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Editors and Affiliations

  1. Klinikum rechts der Isar, Technischen Universität München, München

    Tilo Biedermann

  2. Städtisches Klinikum Karlsruhe, Karlsruhe

    Werner Heppt

  3. Universitätsklinikum Gießen und Marburg GmbH, Marburg

    Harald Renz

  4. Universitätsklinikum Tübingen, Eberhard Karls Universität, Tübingen

    Martin Röcken

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Radbruch, A., Worm, M. (2016). B-Lymphozyten und der Antikörperklassenwechsel zu IgE. In: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (eds) Allergologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37203-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-37203-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37202-5

  • Online ISBN: 978-3-642-37203-2

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