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Adaptive Desaktivierung bei Analgetikaintoleranz

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Allergologie

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Zusammenfassung

Die adaptive Desaktivierung (AD) bei Analgetikaintoleranz ist ein Therapiekonzept, bei welchem durch die langfristige, tägliche Gabe von NSAID, wie bspw. Aspirin, eine Verbesserung des klinischen Verlaufs der Erkrankung erreicht werden kann. Hierbei schließt sich an eine initiale Einleitungsphase mit ansteigenden Dosen von Aspirin eine langjährige Erhaltungsphase mit einer kontinuierlichen Dosierung an. Verschiedene Protokolle für die Durchführung der Einleitungsphase sind publiziert. Auch die Empfehlungen zur optimalen Aspirindosis für die (tägliche) Erhaltungstherapie sind im nationalen und internationalen Vergleich sehr verschieden. Dies unterstreicht die Bedeutung der Durchführung von weiterführenden doppelblind, placebokontrollierten Dosisfindungsstudien zur AD.

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Author information

Authors and Affiliations

  1. Hals-, Nasen-, Ohrenklinik, SLK-Kliniken, Am Gesundbrunnen 20–26, 74078, Heilbronn, Deutschland

    C. Harai

  2. Zentrum für Rhinologie und Allergologie Wiesbaden, HNO-Universitätsklinik Mannheim, An den Quellen 10, 65185, Wiesbaden, Deutschland

    L. Klimek Prof. Dr. med.

  3. Zentrum für Rhinologie und Allergologie Wiesbaden, HNO-Universitätsklinik Mannheim, An den Quellen 10, 65185, Wiesbaden, Deutschland

    O. Pfaar Prof. Dr. med.

Authors
  1. L. Klimek Prof. Dr. med.
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  2. C. Harai
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  3. O. Pfaar Prof. Dr. med.
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Editor information

Editors and Affiliations

  1. Klinikum rechts der Isar, Technischen Universität München, München

    Tilo Biedermann

  2. Städtisches Klinikum Karlsruhe, Karlsruhe

    Werner Heppt

  3. Universitätsklinikum Gießen und Marburg GmbH, Marburg

    Harald Renz

  4. Universitätsklinikum Tübingen, Eberhard Karls Universität, Tübingen

    Martin Röcken

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Klimek, L., Harai, C., Pfaar, O. (2016). Adaptive Desaktivierung bei Analgetikaintoleranz. In: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (eds) Allergologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37203-2_56

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  • DOI: https://doi.org/10.1007/978-3-642-37203-2_56

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37202-5

  • Online ISBN: 978-3-642-37203-2

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