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Atopische Dermatitis

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Allergologie

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Zusammenfassung

Die AD ist eine chronisch-rezidivierende, meist stark juckende Hauterkrankung altersabhängig unterschiedlicher Ausprägung. In den letzten Jahrzehnten kam es zu einem deutlichen Anstieg der AD um das 4- bis 8-Fache. Sowohl genetische Faktoren (mit der Folge von Hautbarrieredefekten und eines gestörten angeborenen und adaptiven Immunsystems) als auch Auslösefaktoren spielen für die Erstmanifestation und das spätere Auftreten von Erkrankungsschüben eine wichtige Rolle. Das klinische Bild ist je nach Stadium der individuellen Hautläsionen und Lebensalter verschieden. Der Juckreiz bestimmt den Leidensdruck, auch die Stigmatisierung und die hohe Rate von Superinfektionen der Haut mindert bei vielen Patienten die Lebensqualität. Beim Management werden individuelle Triggerfaktoren wie Allergene, Hautirritanzien, mikrobielle Erreger oder psychologische Faktoren und deren Meidung der 1. Stufe zugeordnet. Die nächsten beiden Stufen beinhalten die konsequente antiinflammatorische Behandlung mit topischen Kortikosteroiden oder Calcineurininhibitoren. In der 4. Stufe kommen bei sehr schwer ausgeprägter AD antiinflammatorische Systemtherapien zum Einsatz.

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Literatur

  • Wichmann W, Heratizadeh A, Werfel T (2012) Nahrungsmittelallergie bei atopischer Dermatitis. Hautarzt 63: 315–324

    Google Scholar 

Weiterführende Literatur

  • Akdis CA, Akdis M, Bieber T et al. (2006) European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 118: 152–169

    Google Scholar 

  • Bae JM, Choi YY, Park CO, Chung KY, Lee KH (2013) Efficacy of allergen-specific immunotherapy for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol 132: 110–117

    Google Scholar 

  • Breuer K, Kapp A, Werfel T (2001) Bacterial infections and atopic dermatitis. Allergy 56: 1034–1041

    Google Scholar 

  • Bußmann C, Bieber T, Novak N (2009) Systemic therapeutic options for severe atopic dermatitis. J Dtsch Dermatol Ges 7: 205–219

    Google Scholar 

  • Darabi K, Hostetler SG, Bechtel MA, Zirwas M (2009) The role of Malassezia in atopic dermatitis affecting the head and neck of adults. J Am Acad Dermatol 60: 125–136

    Google Scholar 

  • Dondi A, Ricci L, Neri I, Ricci G, Patrizi A (2013) The switch from non-IgE-associated to IgE-associated atopic dermatitis occurs early in life. Allergy 68: 259–260

    Google Scholar 

  • Ehmann LM, Vogel S, Müller-Wiefel S, Wollenberg A (2012) Proaktive Therapie – ein innovatives Langzeittherapiekonzept zur Schubreduktion Allergologie 35: 425–432

    Google Scholar 

  • Heine G, Schnuch A, Uter W, Worm M; Information Network of Departments of Dermatology (IVDK); German Contact Dermatitis Research Group (DKG) (2006) Type-IV sensitization profile of individuals with atopic eczema: results from the Information Network of Departments of Dermatology (IVDK) and the German Contact Dermatitis Research Group (DKG). Allergy 61: 611–616

    Google Scholar 

  • Heratizadeh A, Wichmann K, Werfel T (2011) Food allergy and atopic dermatitis: how are they connected? Curr Allergy Asthma Rep 11: 284–291

    Google Scholar 

  • Irvine AD, McLean WH, Leung DY (2011) Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 365: 1315–1327

    Google Scholar 

  • Kapp A, Papp K, Bingham A et al. (2002) Flare Reduction in Eczema with Elidel (infants) multicenter investigator study group. Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug. J Allergy Clin Immunol 110: 277–284

    Google Scholar 

  • Kaesler S, Volz T, Skabytska Y, Köberle M, Hein U, Chen KM, Guenova E, Wölbing, F, Röcken M, Biedermann T (2014) Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10. J Allergy Clin Immunol 134: 92–99

    Google Scholar 

  • Majoie IM, Oldhoff JM, van Weelden H et al. (2009) Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis. J Am Acad Dermatol 60: 77–84

    Google Scholar 

  • Mrowietz U, Klein CE, Reich K, Rosenbach T, Ruzicka T, Sebastian M, Werfel T (2009) Cyclosporine therapy in dermatology. J. Dtsch. Dermatol. Ges 7: 474–479

    Google Scholar 

  • Muche-Borowski C, Kopp M, Reese I, Sitter H, Werfel T, Schäfer T (2009) Allergy prevention. Dtsch Arztebl Int 106: 625–631

    Google Scholar 

  • Novak N, Bieber T, Hoffmann M, Fölster-Holst R et al. (2012) Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol 130: 925–931

    Google Scholar 

  • Pellerin L, Henry J, Hsu CY et al. (2013) Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin. J Allergy Clin Immunol 131: 1094–1102

    Google Scholar 

  • Reitamo S, Allsopp R (2010) Treatment with twice-weekly tacrolimus ointment in patients with moderate to severe atopic dermatitis: results from two randomized, multicentre, comparative studies. J Dermatolog Treat 21: 34–44

    Google Scholar 

  • Ring J, Alomar A, Bieber T, Deleuran M et al. (2012) Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol 26: 1045–1060

    Google Scholar 

  • Ring J, Alomar A, Bieber T, Deleuran M et al. (2012) Guidelines for treatment of atopic eczema (atopic dermatitis) Part II. J Eur Acad Dermatol Venereol 26: 1176–1193

    Google Scholar 

  • Roekevisch E, Spuls PI, Kuester D, Limpens J, Schmitt J (2014) Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review. J Allergy Clin Immunol 133: 429–438

    Google Scholar 

  • Schmitz R, Atzpodien K, Schlaud M (2012) Prevalence and risk factors of atopic diseases in German children and adolescents. Pediatr Allergy Immunol 23: 716–723

    Google Scholar 

  • Sher LG, Chang J, Patel IB, Balkrishnan R, Fleischer AB Jr (2012) Relieving the pruritus of atopic dermatitis: a meta-analysis. Acta Derm Venereol 92: 455–461

    Google Scholar 

  • Staab D, Diepgen TL, Fartasch M et al. (2006) Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial. BMJ 332: 933–938

    Google Scholar 

  • Thyssen JP, Linneberg A, Engkilde K, Menné T, Johansen JD (2012) Contact sensitization to common haptens is associated with atopic dermatitis: new insight. Br J Dermatol 166: 1255–1261

    Google Scholar 

  • Werfel T (2009) The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol 129: 1878–1891

    Google Scholar 

  • Werfel T, Claes C, Kulp W, Greiner W, von der Schulenburg JM (2006) HTA-Bericht: Therapie der Neurodermitis. GMS Health Technol Assess, Vol. 2. http://www.egms.de/static/pdf/journals/hta/2006-2/hta000032.pdf. Zugegriffen: 16.01.2015

  • Werfel T, Ballmer-Weber B, Eigenmann PA, Niggemann B, Rancé F, Turjanmaa K, Worm M (2007) Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN. Allergy 62: 723–728

    Google Scholar 

  • Werfel T, Lotte C, Scheewe S, Staab D (2008) Manual Atopische Dermatitisschulung. Dustri Verlag Dr. Karl Feistle, München, Orlando

    Google Scholar 

  • Werfel T, Aberer W, Augustin M (2009) et al. Atopische Dermatitis: S2 guidelines. J Dtsch Dermatol Ges 7: 1–46

    Google Scholar 

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Authors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, OE6610, 30625, Hannover, Deutschland

    T. Werfel Prof. Dr. med.

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  1. T. Werfel Prof. Dr. med.
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Editors and Affiliations

  1. Klinikum rechts der Isar, Technischen Universität München, München

    Tilo Biedermann

  2. Städtisches Klinikum Karlsruhe, Karlsruhe

    Werner Heppt

  3. Universitätsklinikum Gießen und Marburg GmbH, Marburg

    Harald Renz

  4. Universitätsklinikum Tübingen, Eberhard Karls Universität, Tübingen

    Martin Röcken

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Werfel, T. (2016). Atopische Dermatitis. In: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (eds) Allergologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37203-2_23

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  • DOI: https://doi.org/10.1007/978-3-642-37203-2_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37202-5

  • Online ISBN: 978-3-642-37203-2

  • eBook Packages: Medicine (German Language)

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