Skip to main content
SpringerLink
Log in

Pathogenetische Grundlagen pseudoallergischer Reaktionen

  • Chapter
Allergologie

  • 6546 Accesses

Zusammenfassung

Verschiedene Pathomechanismen können zu Symptomen führen, die allergischen Symptomen ähneln, nicht aber Sensibilisierungen zur Grundlage haben. Diese Mechanismen und resultierenden Krankheitsbilder werden diskutiert, einschließlich der Histaminintoleranz, Reaktionen auf ACE-Hemmer oder Augmentierungen allergischer Reaktionen. Eine besondere Bedeutung kommt Unverträglichkeitsreaktionen auf nichtsteroidale Entzündungshemmer (NSAID) zu. Verschiedene Formen wie Exazerbationen eines vorbestehenden Asthmas oder einer Urtikaria, aber auch die direkte Auslösung von Urtikaria und Anaphylaxie durch NSAID aufgrund deren Einfluss auf den Arachidonsäuremetabolismus u. a. bei möglichen Polymorphismen müssen unterschieden werden von echten, nach Sensibilisierungen sich manifestierenden, IgE-vermittelten gleichen Symptomen von NSAIDs, wie insbesondere den Pyrazolonen oder Diclofenac.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Abuaf N, Rostane H, Barbara J, Toly-Ndour C, Gaouar H, Mathelier-Fusade P, Leynadier F, Francés C, Girot R (2012) Comparison of CD63 upregulation induced by NSAIDs on basophils and monocytes in patients with NSAID hypersensitivity. J Allergy (Cairo): 580873

    Google Scholar 

  • Agúndez JAG, Ayuso P, Cornejo-Garcia JA, Blanca M, Torres MJ, Doňa I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martinez C, Garcia-Martin E (2012) The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-antiflammatory drugs. PLOS ONE 7(11): e47571

    Google Scholar 

  • Ayuso P, Blanca-López N, Doňa I, Torres MJ, Guéant-Rodriguez RM, Canto G, Sanak M, Mayorga C, Guéant JL, Blanca M, Cornejo-Garcia JA (2013) Advanced phenotyping in hypersensitivity drug reactions to NSAIDs. Clin Exp Allergy 43: 1097–1109

    Google Scholar 

  • Bae JS, Kim SH, Ye YM, Yoon HJ, Suh CH, Nahm DH, Park HS (2007) Significant association of FcεRIα promoter polymorphisms with aspirin-intolerant chronic urticaria. J Allergy Clin Immunol 119: 449–456

    Google Scholar 

  • Barbaud A, Granel F, Waton J, Poreaux C (2011) How to manage hypersensitivity reactions to biological agents? Eur J Dermatol 21(5): 667–674

    Google Scholar 

  • Brockow K, Ring J (2011) Anaphylaxis to radiographic contrast media. Curr Opin Allergy Clin Immunol 11(4): 326–331

    Google Scholar 

  • Celik GE, Schroeder JT, Hamilton RG, Saini SS, Adkinson NF (2009) Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. Clin Exp Allergy 39(10): 1522–1523

    Google Scholar 

  • Chandler MJ, Grammer I, Patterson R (1987) Provocative challenge with local anesthetics in patients with a prior history of reactions. J Allergy Clin Immunol 79: 883–886

    Google Scholar 

  • Chassande O, Renard S, Barbry P, Lazdunski M (1994) The human gene for diamine oxidase, an amiloride binding protein. Journal of Biological Chemistry 269(20): 14484–14489

    Google Scholar 

  • Cuesta-Herranz J, Heras M de las, Fernandes M, Lluch M, Figueredo E, Umpierrez A, Lahoz C (1997) Allergic reaction caused by local anesthetic agents belonging to the amide group. J Allergy Clin Immunol 99: 427–428

    Google Scholar 

  • Czech W, Busse A, Wedi B, Kapp A (1996) Nahrungsmitteladditiva und nicht-steroidale Antiphlogistika – Auslöser von pseudoallergischen Reaktionen. Allergologie 19: 442–448

    Google Scholar 

  • Dahlen B, Dahlen SE (1995) Intolerance reactions to NSAIDs. In: Basomba A, Sastre J (Hrsg) Proceedings of XVIth European Congress of Allergology and Clinical Immunology. Monduzzi Editore, Bologna, S 821–828

    Google Scholar 

  • Dollner R, Hörmann K, Stuck BA, Pfaar O, Klimek L (2014) In vitro Diagnostik des AASAS-Intoleranz-Syndroms (Aspirin-exacerbated respiratory disease: AERD). Allergologie 37: 11–19

    Google Scholar 

  • Ehlers I, Henz B, Zuberbier T (1996) Diagnose und therapie pseudo-allergischer Reaktionen der Haut durch Nahrungsmittel. Allergologie 19: 270–276

    Google Scholar 

  • Erdmann S, Merk HF, Sachs B (2003) Intoleranzreaktionen. Dtsch Med Wochenschr 128: 1715–1720

    Google Scholar 

  • Gall H, Kaufmann R, Kalveram CM (1996) Adverse reactions to local anesthetics; analysis of 197 cases. J Allergy Clin Immunol 97: 933–937

    Google Scholar 

  • Götz M, Wantke F, Focke M, Wolf-Abdolvahab S, Jarisch R (1996) Histaminintoleranz und Diaminoxidasemangel. Allergologie 19: 394–398

    Google Scholar 

  • Hsieh CW, Lee JW, Liao EC, Tsai JJ (2014) A disease marker for aspirin-induced chronic urticaria. Int J Mol Sci 15: 12591–12603

    Google Scholar 

  • Jarisch R, Götz M, Hemmer W, Missbichler A, Raithel M, Wantke F (2004): Histamin-Intoleranz. Thieme, Stuttgart

    Google Scholar 

  • Jung JW, Kang HR, Kim MH, Lee W, Min KU, Han MH, Cho SH (2012) Immediate hypersensitivity reaction to Gadolinium-based MR contrast media. Radiology 264 (2): 414–422

    Google Scholar 

  • Kim SH, Sanak M, Park HS (2013) Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs. Immunol Allergy Clin N Am 33: 177–194

    Google Scholar 

  • Klimek L (2014): ASS-Intoleranz-Syndrom. Allergologie 37: 2–3

    Google Scholar 

  • Klimek L, Pfaar O, Kirsche H (2014): Die adaptive Desaktivierungsbehandlung bei Patienten mit ASS-Intoleranz_Syndrom: Übersicht über ein ursächlich-orientiertes Therapiekonzept. Allergologie 37: 26–33

    Google Scholar 

  • Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G, Bousquet J, Bousquet P, Celik G, Demoly P, Gomes ER, Nizankowska-Mogilnicka E, Romano M, Sanchez-Borges M, Sanz M, Torres MJ, De Weck A, Szczeklik A, Brockow K (2011) Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) – classification, diagnosis and management: review of the EAACI/ENDA and GA2LEN/HANNA. Allergy 66(7): 818–829

    Google Scholar 

  • Maintz L, Yu CF, Rodriguez E, Baurecht H, Bieber T, Illig T, Weidinger S, Novak N (2011) Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy 66: 893–902

    Google Scholar 

  • Melnik B, Szliska C, Nöhle M, Schwanitz HJ (1997) Nahrungsmittelunverträglichkeiten. Allergologie 19: 163–167

    Google Scholar 

  • Merk H, Goerz G (1983) Analgetika-Intoleranz. Z Hautkr 58: 535–542

    Google Scholar 

  • Merk H (2008) Anaphylaxie durch Arzneimittel. Allergo J 18: 444–454

    Google Scholar 

  • Merk H (2007) Angioödem. Hautarzt 58: 1041–1045

    Google Scholar 

  • Merk HF (2012) Arzneimittelreaktionen. In: J. Saloga, R.Buhl, WJ Mann, J Knop, S.Grabbe: (Hrsg) Allergologie-Handbuch, Schattauer, Stuttgart, S 426–438

    Google Scholar 

  • Merk HF (2014) Unerwünschte Arzneimittelwirkungen der Haut. In: H Morck, E Strehl (Hrsg) Unerwünschte Arzneimittelwirkungen, Govi-Verlag, Stuttgart, S 111–123

    Google Scholar 

  • Morrow JD (1991) Evidence that histamine is the causative toxin of scombroidfish poisoning. N Engl J Med 324: 716–720

    Google Scholar 

  • Mullarkey MF, Thomas PC, Hansen JA (1986) Association of aspirin-sensitive asthma with HLA-DQw2. Am Rev Respir Dis 133: 261–264

    Google Scholar 

  • Newmark JL, Mehra A, Singla AK (2012) Radiocontrast media allergic reactions and interventional pain practice--a review. Pain Physician. 15: E665–75

    Google Scholar 

  • O’Sullivan S, Dahlen B, Dahlen SE, Kumlin M (1996) Increased urinary excretion of the prostaglandin D2 metabolite 9α, 11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. J Allergy Clin Immunol 98: 421–432

    Google Scholar 

  • Panto PN, Davies P (1986) Delayed reactions to urographic contrast media. Br J Radiol, 59: 41–44

    Google Scholar 

  • Purcell RT, Lockey RF (2008) Immunologic responses to therapeutic biologic agents. J Investig Allergol Clin Immunol 18(5): 335–342

    Google Scholar 

  • Reese I, Zuberbier T, Bunselmeyer B, Erdmann S, Henzgen M, Fuchs T, Jäger L, Kleine-Tebbe J, Lepp U, Niggemann B, Raithel M, Saloga J, Vieths S, Werfel T (2009) Diagnostisches Vorgehen bei Verdacht auf eine pseudoallergische Reaktion durch Nahrungsmittelinhaltsstoffe. JDDG 7: 70–77

    Google Scholar 

  • Ring J (1978) Anaphylaktoide Reaktionen. Springer, Heidelberg

    Google Scholar 

  • Ruzicka T, Gerstmeier M, Przybilla B, Ring J (1987) Allergy to local anesthetics: comparison of patch test with prick and intradermal test results. J Am Acad Derm 16: 1202–1208

    Google Scholar 

  • Sánchez-Borges M, Acevedo N, Caraballo L, Capriles-Hulett A, Caballero-Fonseca F (2010) Increased total and mite-specific immunoglobulin E in patients with aspirin-induced urticaria and angioedema. J Invest Allergol Clin Immunol 20(2): 139–145

    Google Scholar 

  • Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CEM, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, van der Laan JW, Weaver RJ, Park BK (2013) Challenges and approaches for the development of safer immunomodulatory biologics. Nature 12: 306–324

    Google Scholar 

  • Schatz M (1984) Skin testing and incremental challenge in the evaluation of adverse reactions to local anesthetics. J Allergy Clin Immunol 74: 606–645

    Google Scholar 

  • Stevenson DD, Szczeklik A (2006) Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol 118: 773–786

    Google Scholar 

  • Suzuki Y, Ra C (2009) Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: Aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. J Pharmacol Sci 110: 237–244

    Google Scholar 

  • Swierczynska-Krepa M, Sanak M, Bochenek G, Strek P, Cmiel A, Gielicz A, Plutecka H, Szczeklik A, Nizankowska-Mogilnicke E (2014) Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: a double-blind study. J Allergy Clin Immunol 134(4): 883–890

    Google Scholar 

  • Wedi B, Elsner J, Kapp A (1996) In vitro diagnosis of pseudoallergic reactions – new aspects. ACI 8: 113–115

    Google Scholar 

  • Weiss ME (1992) Drug allergy. Med Clin North Am 76: 857–882

    Google Scholar 

  • Wölbing F, Biedermann T (2013) Anaphylaxis: opportunities of stratified medicine for diagnose and risk assessment. Allergy 68: 1499–1508

    Google Scholar 

  • Wölbing F, Fischer M, Köberle M, Kaesler S, Biedermann T (2013a) About the role and underlying mechanisms of cofactors in anaphylaxis. Allergy 68: 1085–1092

    Google Scholar 

  • Wölbing F, Kaesler S, Kempf W, Siraskar B, Eckstein P, Köberle M, Skabytska Y, Lang F, Yu P, Voehringer D, Röcken M, Biedermann T (2013b) Anaphylaxis triggered by innate immune signals as co-factors is mediated by basophils independent of IgE J invest Dermatol 133: S5

    Google Scholar 

  • Wüthrich B (1993) Adverse reactions to food additives. Ann Allergy 71: 379–384

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitäts-Hautklinik, RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    H. F. Merk Prof. Dr. med.

Authors
  1. H. F. Merk Prof. Dr. med.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinikum rechts der Isar, Technischen Universität München, München

    Tilo Biedermann

  2. Städtisches Klinikum Karlsruhe, Karlsruhe

    Werner Heppt

  3. Universitätsklinikum Gießen und Marburg GmbH, Marburg

    Harald Renz

  4. Universitätsklinikum Tübingen, Eberhard Karls Universität, Tübingen

    Martin Röcken

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Merk, H.F. (2016). Pathogenetische Grundlagen pseudoallergischer Reaktionen. In: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (eds) Allergologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37203-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-37203-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37202-5

  • Online ISBN: 978-3-642-37203-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation