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Antiallergika

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Zusammenfassung

Antiallergika werden zur Behandlung der allergischen Rhinitis und Konjunktivitis, des Asthma bronchiale, allergischer Hautreaktionen (z. B. Urtikaria, Pruritus) und generalisierter allergischer Krankheiten (z. B. Insektengiftallergien, anaphylaktische Reaktionen) eingesetzt. In diesem Kapitel werden schwerpunktmäßig H1-Antihistaminika und Hyposensibilisierungsmittel besprochen. Weitere Arzneimittel für allergische Indikationen werden in den Kapiteln über Bronchospasmolytika (Kapitel 19), Corticosteroide (Kapitel 21), Dermatika (Kapitel 22), Ophthalmika (Kapitel 36) und Rhinologika (Kapitel 40) dargestellt.

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Literatur

  • Arzneimittelkommission der deutschen Ärzteschaft (2007): Stellungnahme der AkdÄ zur allergenspezifischen Immuntherapie. Dtsch Ärztebl 104: A 3355–3357.

    Google Scholar 

  • Abramson M, Puy R, Weiner J (2003): Allergen immunotherapy for asthma (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.

    Google Scholar 

  • Adkinson NF, Eggleston PA, Eney D, Goldstein EO, Schuberth KC et al. (1997): A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med 336: 324–331.

    Article  PubMed  CAS  Google Scholar 

  • Arvidsson MB, Löwhagen O, Rak S (2002): Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy. J Allergy Clin Immunol 109: 777–783.

    Article  PubMed  CAS  Google Scholar 

  • Aust W, Wichmann G, Dietz A (2010): Therapiekontrolle der Insektengifthyposensibilisierung. Laryngorhinootologie 89: 725–728.

    Article  PubMed  CAS  Google Scholar 

  • Austen KF (2001): Allergies, anaphylaxis, and systemic mastocytosis. In: Braunwald E et al. (eds): Harrison’s principles of internal medicine. McGraw-Hill Medical Publishing Division, New York, pp. 1913–1922.

    Google Scholar 

  • Bousquet J, Hejjaoui A, Clauzel AM, Guerin B, Dhivert H, Skassa-Brociek W, Wichel FB (1988): Specific immunotherapy with a standardized Dermatophagoides pteronyssinus extract. II. Prediction of efficacy of immunotherapy. J Allergy Clin Immunol 82: 971–977.

    Article  PubMed  CAS  Google Scholar 

  • Bousquet J, Scheinmann P, Guinnepain MT, Perrin-Fayolle M, Sauvaget J, Tonnel AB et al. (1999): Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 54: 249–260.

    Article  PubMed  CAS  Google Scholar 

  • Bundesministerin für Gesundheit (2008): Verordnung über die Ausdehnung der Vorschriften über die Zulassung der Arzneimittel auf Therapieallergene, die für einzelne Personen auf Grund einer Rezeptur hergestellt werden, sowie über Verfahrensregelungen der staatlichen Chargenprüfung (Therapieallergene-Verordnung) vom 7. November 2008. Bundesgesetzblatt 2008 Teil I Nr. 51, Bonn 13. November 2008, Seite 2177–2178. Internet: www.bgbl.de/Xaver/start.xav?startbk=Bundesanzeiger_BGBl

  • Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S (2007): Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev. 2007 Jan 24; (1): CD001936.

    Google Scholar 

  • Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W, Rivas MF, Ribel M, Durham SR (2006): Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 118: 434–440.

    Article  PubMed  CAS  Google Scholar 

  • Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W, Riis B, Grønager PM, Durham SR (2008): Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. J Allergy Clin Immunol 121: 512–518.

    Article  PubMed  CAS  Google Scholar 

  • Deutsche Gesellschaft für Allergologie und klinische Immunologie (2009): Die spezifische Immuntherapie (Hyposensibilisierung) bei IgE-vermittelten allergischen Erkrankungen. Allergo J 18: 508–537. Internet: www.dgaki.de/wp-content/uploads/2010/05/Leitlinie_SIT2009.pdf

  • Didier A, Malling HJ, Worm M, Horak F, Jäger S, Montagut A, Andre C, Beaumont O de, Melac M (2007): Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grasspollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 120: 1338–1345.

    Article  PubMed  CAS  Google Scholar 

  • Durham SR (2008): Sublingual immunotherapy: what have we learnt from the ‚big trials’? Curr Opin Allergy Clin Immunol 8: 577–584.

    Article  PubMed  Google Scholar 

  • Durham SR, Emminger W, Kapp A, de Monchy JG, Rak S, Scadding GK, Wurtzen PA, Andersen JS, Tholstrup B, Riis B, Dahl R (2012): SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol 129: 717–725.

    Article  PubMed  Google Scholar 

  • Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brian F, Noble W et al. (1999): Long- term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341: 468– 475.

    Article  PubMed  CAS  Google Scholar 

  • Golden DB (2005): Insect sting allergy and venom immunotherapy: a model and a mystery. J Allergy Clin Immunol 115: 439–47.

    Article  PubMed  Google Scholar 

  • Guez S, Vatrinet C, Fadel R, Andre C (2000): House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy 55: 369–375.

    Article  PubMed  CAS  Google Scholar 

  • Hoff M, Krail M, Kästner M, Haustein D, Vieths S (2002): Fusarium culmorum causes strong degradation of pollen allergens in extract mixtures. J Allergy Clin Immunol 109: 96–101.

    Article  PubMed  Google Scholar 

  • Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio FJ, Lichtenstein LM (1978): A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med 299: 157–161.

    Article  PubMed  CAS  Google Scholar 

  • Kassenärztliche Vereinigung Bayern (2010): Neue Therapieallergene-Verordnung sorgt für Bewegung auf dem Markt. Arzneimittel im Blickpunkt Nr. 30, Mai 2010. Internet: www.kvb.de/fileadmin/data/dokumente/2_Praxis/2.6.5_Verordnungen/2.6.2_Blickpunkt/KVB-100503-WIS-Therapieallergene-Verordnung-Ausgabe-30-Arzneimittelim-Blickpunkt.pdf

  • Lin SY, Erekosima N, Kim JM, Ramanathan M, Suarez-Cuervo C, Chelladurai Y, Ward D, Segal JB (2013): Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. JAMA 309: 1278–1288.

    Article  PubMed  CAS  Google Scholar 

  • Lüderitz-Püchel U, Keller-Stanislawski B, Haustein D (2001): Neubewertung des Risikos von Test- und Therapieallergenen. Eine Analyse der UAW-Meldungen von 1991 bis 2000. Bundesgesunheitsbl - Gesundheitsforsch - Gesundheitsschutz 44: 709–718.

    Article  Google Scholar 

  • Mellerup MT, Hahn GW, Poulsen LK, Malling HJ (2000): Safety of allergen-specific immunotherapy. Relation between dosage regimen, allergen extract, disease and systemic side-effects during induction treatment. Clin Exp Allergy. 30: 1423–1429.

    Article  PubMed  CAS  Google Scholar 

  • Möller C, Dreborg S, Ferdousi HA, Halken S, Høst A, Jacobsen L et al. (2002): Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study). J Allergy Clin Immunol 109: 251–256.

    Article  PubMed  Google Scholar 

  • Moffitt JE, Golden DB, Reisman RE, Lee R, Nicklas R, Freeman T, deshazo R, Tracy J, Bernstein IL, Blessing-Moore J, Khan DA, Lang DM, Portnoy JM, Schuller DE, Spector SL, Tilles SA (2004): Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol 114: 869–886.

    Article  PubMed  Google Scholar 

  • Nelson HS (2007): Allergen immunotherapy: where is it now? J Allergy Clin Immunol 119: 769–779.

    Article  PubMed  CAS  Google Scholar 

  • Olsen OT, Larsen KR, Jacobsan L, Svedsen UG (1997): A 1-year placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults. Allergy 52: 853–859.

    Article  PubMed  CAS  Google Scholar 

  • O’Neill SM, Forsyth A (1988): Urticaria. Prescribers J 28: 14–20.

    Google Scholar 

  • Petersen BN, Janniche H, Munch EP, Wihl JA, Bowadt H, Ipsen H, Lowenstein H (1988): Immunotherapy with partially purified and standardized tree pollen extracts. I. Clinical results from a three-year double-blind study of patients treated with pollen extracts either of birch or combinations of alder, birch and hazel. Allergy 43: 353–362.

    Article  PubMed  CAS  Google Scholar 

  • Pfaar O, Jung K, Wolf H, Decot E, Kleine-Tebbe J, Klimek L, Wüstenberg E (2012): Immunological effects and tolerability of a new fast updosed immunologically enhanced subcutaneous immunotherapy formulation with optimized allergen/adjuvant ratio. Allergy 67: 630–637.

    Article  PubMed  CAS  Google Scholar 

  • Pichler CE, Helbling A, Pichler WJ (2001): Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity. Allergy 56: 301–306.

    Article  PubMed  CAS  Google Scholar 

  • Pichler CE, Marquardsen A, Sparholt S, Lowenstein H, Bircher A, Bischof M, Pichler WJ (1997): Specific immunotherapy with Dermatophagoides ptheronyssinus and D. farinae results in decreased bronchial hyperreactivity. Allergy 52: 274–283.

    Article  PubMed  CAS  Google Scholar 

  • Przybilla B, Ruëff F (2010): Hymenoptera venom allergy. J Dtsch Dermatol Ges 8: 114–127.

    Article  PubMed  Google Scholar 

  • Przybilla B, Ruëff F (2010): Hymenoptera venom allergy. J Dtsch Dermatol Ges 8: 114–127. Radulovic S, Wilson D, Calderon M, Durham S (2011): Systematic reviews of sublingual immunotherapy (SLIT). Allergy 66: 740–752.

    Article  PubMed  CAS  Google Scholar 

  • Ring J, Fuchs T, Schultze-Werninghaus G (Hrsg.) (2004) DGAI, ÄDA, DAAU: Weißbuch Allergie in Deutschland, 2. Aufl. Urban und Vogel München.

    Google Scholar 

  • Routledge PA, Lindquist M, Edwards IR (1999): Spontaneous reporting of suspected adverse reactions to antihistamines: a national and international perspective. Clin Exp Allergy 29 (Suppl 3): 240–246.

    Article  PubMed  Google Scholar 

  • Sennekamp J, Fuchs Th, Hornung B., Kersten W, Klimek L, Leupold W, Merk H, Rebien W, Schultze-Werninghaus G (2002): Empfehlungen zur praktischen Durchführung der spezifischen Immuntherapie mit Allergenen. Allergo J 11: 332–338.

    Google Scholar 

  • Simons FE, Simons KJ (2011): Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 128: 1139–1150.

    Article  PubMed  CAS  Google Scholar 

  • Valsecchi R, di Landro A, Pansera B, Cainelli T (1994): Contact dermatitis from a gel containing dimethindene maleate. Contact Dermatitis. 30: 248–249.

    Google Scholar 

  • Warner JO, Price JF, Soothill JF, Hey EN (1978): Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma. Lancet 2: 912–915.

    Article  PubMed  CAS  Google Scholar 

  • WHO Position Paper (1998): Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 53 (Suppl 1): 1-42.

    Google Scholar 

  • Wilson DR, Torres-Lima M, Durham SR (2010): Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002893.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Wissenschaftliches Institut der AOK, Berlin, Rosenthaler Straße 31, 10178

    Dr. rer. nat. Anette Zawinell

  2. Pharmakologisches Institut, Universität Heidelberg, Heidelberg, Im Neuenheimer Feld 366, 69120

    Prof. Dr. med. Ulrich Schwabe

Authors
  1. Dr. rer. nat. Anette Zawinell
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  2. Prof. Dr. med. Ulrich Schwabe
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Editors and Affiliations

  1. Pharmakologisches Institut, der Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Ulrich Schwabe

  2. AOK NORDWEST Die Gesundheitskasse, Edisonstraße 70, 24145, Kiel

    Dieter Paffrath

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Zawinell, A., Schwabe, U. (2013). Antiallergika. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2013. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37124-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-37124-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37123-3

  • Online ISBN: 978-3-642-37124-0

  • eBook Packages: Medicine (German Language)

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