Zusammenfassung
Therapeutisch werden peripher und zentral wirkende Muskelrelaxantien unterschieden. Während peripher wirkende Muskelrelaxantien vor allem zur Muskelrelaxation bei Narkose eingesetzt werden, kommen zentral wirkende Muskelrelaxantien überwiegend bei der Behandlung krankhafter Tonuserhöhungen der Skelettmuskulatur zur Anwendung.
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Literatur
Bundesinstitut für Arzneimittel und Medizinprodukte, Auswertung der Spontanmeldungen zu Tolperison (UAW-Datenbank des BfArM), Schreiben vom 10. Mai 2011.
Cardoso E, Rodrigues B, Lucena R, Oliveira IR, Pedreira G, Melo A (2005): Botulinum toxin type A for the treatment of the upper limb spasticity after stroke: a meta-analysis. Arq Neuropsiquiatr 63: 30–33.
Chou R, Peterson K, Helfand M (2004): Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage 28: 140–175.
Costa J, Espírito-Santo CC, Borges AA, Ferreira J, Coelho MM, Moore P, Sampaio C (2004): Botulinum toxin type A therapy for blepharospasm. Cochrane Database of Systematic Reviews 2004, Issue 2. Art. No.: CD004900. DOI: 10.1002/14651858. CD004900.pub2.
Costa J, Espírito-Santo CC, Borges AA, Ferreira J, Coelho MM, Moore P, Sampaio C (2005a): Botulinum toxin type A therapy for cervical dystonia. Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD003633. DOI: 10.1002/14651858. CD003633.pub2.
Costa J, Espírito-Santo CC, Borges AA, Ferreira J, Coelho MM, Moore P, Sampaio C (2005b): Botulinum toxin type A therapy for hemifacial spasm. Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD004899. DOI: 10.1002/14651858. CD004899.pub2.
Deutsche Gesellschaft für Neurologie (2012): Leitlinie Therapie des spastischen Syndroms. www.dgn.org/component/content/article/45-leitlinien-der-dgn-2012/2431-ll-89-2012-therapie-des-spastischen-syndroms.html?q=spastikLetzterZugriff16.Mai2013.
Dulin J, Kovács L, Ramm S, Horvath F, Ebeling L, Kohnen R (1998): Evaluation of sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, ran-domized, double-blind, placebo-controlled trial. Pharmacopsychiatry. 31: 137–142.
Duthie JB, Vincent M, Herbison GP, Wilson DI, Wilson D (2011): Botulinum toxin injections for adults with overactive bladder syndrome. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD005493. DOI: 10.1002/14651858.CD005493. pub3.
Elia AE, Filippini G, Calandrella D, Albanese A (2009): Botulinum neurotoxins for poststroke spasticity in adults: a systematic review. Mov Disord 24: 801–812.
European Medicines Agency (2009): Questions and answers on the referral for Myderison tablets containing tolperisone hydrochloride 50 and 150 mg. Internet: www.ema.europa.eu/pdfs/human/referral/myderison/ha_281118q&a.pdf , letzter Zugriff 16. Mai 2013.
European Medicines Agency (2013a): Recommendation to suspend tetrazepam-containing medicines endorsed by CMDh: 29 April 2013 EMA/256383/2013.
European Medicines Agency (2013b): Questions and answers on the review of tolperisonecontaining medicines. Outcome of a procedure under Article 31 of Directive 2001/83/ EC as amended. 21 January 2013 EMA/673365/2012 rev.1 EMEA/H/ A-31/1311.
Fricke U, Günther J, Zawinell A, Zeidan R (2013): Anatomisch-therapeutisch-chemische Klassifikation mit Tagesdosen für den deutschen Arzneimittelmarkt. Methodik der ATC-Klassifikation und DDD-Festlegung. WIdO GKV-Arzneimittelindex. Internet: www.wido.de/arz_atcddd-klassifi.html.
Gemeinsamer Bundesausschuss (2012): Beschluss des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL): Anlage XII – Beschlüsse über die Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a SGB V – Fampridin vom 2. August 2012. Internet: www.g-ba.de/downloads/39-261-1541/2012-08-02_AM-RL-XII_Fampridin_BAnz.pdf.
GKV-Spitzenverband, Biogen Idec GmbH (2013): AMNOG-Verhandlungen für MS-Therapeutikum erfolgreich beendet. Gemeinsame Pressemitteilung – Berlin, 01.03.2013. Internet: www.gkv-spitzenverband.de/media/dokumente/presse/pressemitteilungen/2013/Gem_PM_2013-03-01_AMNOG_Fampridin.pdf.
Hoare BJ, Wallen MA, Imms C, Villanueva E, Rawicki HB, Carey L (2010): Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE). Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD003469. DOI: 10.1002/14651858.CD003469.pub4.
Infomed (2003): Anaphylaktische Reaktionen unter Tolperison (Mydocalm®) vom 27. Oktober 2003 www.infomed.ch/bdn.php?bdnid=185, Letzter Zugriff 16. Mai 2013.
Jackson JL, Kuriyama A, Hayashino Y (2012): Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis. JAMA 307: 1736– 1745.
Keane RE, Simiand J, Morre M, Biziere K (1988a): Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents. J Pharmacol Exp Ther 245: 692–698.
Keane RE, Bachy A, Morre M, Biziere K (1988b): Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. II. In vitro and in vivo interactions with benzodiazepine binding sites. J Pharmacol Exp Ther 245: 699–705.
Kirschner J, Berweck S, Mall V, Korinthenberg R, Heinen F (2001): Botulinumtoxin – Neue Therapieoption für Kinder mit Zerebralparese. Dtsch Ärztebl 98: A3375–A3379.
Programm für Nationale VersorgungsLeitlinien (2011): Nationale VersorgungsLeitlinie Kreuzschmerz. Langfassung: Internet: www.versorgungsleitlinien.de/themen/kreuzschmerz/pdf/nvl_kreuzschmerz_lang.pdf.
Quasthoff S, Möckel C, Zieglgänsberger W, Schreibmayer W (2008): Tolperisone: A typical representative of a class of centrally acting muscle Relexnants with less sedative side effects. CNS Neurol Therap 14: 107–119.
Shakespeare DT, Boggild M, Young C (2003): Anti-spasticity agents for multiple sclerosis. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD001332. DOI: 10.1002/14651858.CD001332.
Simiand J, Keane PE, Biziere K, Soubrie P (1989): Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch Int Pharmacodyn Ther 297: 272–285.
van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM (2003): Muscle relaxants for non-specific low-back pain. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD004252. DOI: 10.1002/14651858.CD004252.
Waelbroeck M, Camus J, Tastenoy M, Lambrecht G, Mutschler E, Kropfgans M et al (1993): Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type. Br J Pharmacol 109: 360–370.
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Günther, J. (2013). Muskelrelaxantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2013. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37124-0_35
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