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Zusammenfassung

Die Arzneitherapie ist das wichtigste Verfahren zur Behandlung von Epilepsien. Maßgebend für die Auswahl von Antiepileptika sind arzneimittelspezifische Variable (Anfallstyp, Nebenwirkungsprofil, Teratogenität, Pharmakokinetik, Interaktionspotenzial, Arzneiformen) und Patienten- abhängige Faktoren (Alter, Geschlecht, Komedikation, Begleitkrankheiten, genetischer Hintergrund) (McCorry et al. 2004, Glauser et al. 2006).

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Literatur

  • Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, et al. for the Gabapentin Diabetic Neuropathy Study Group (1998): Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus. JAMA 280: 1831–1836.

    Google Scholar 

  • Ben-Menachem E, Biton V, Jatuzis D, Abou-Khalil B, Doty P, Rudd GD (2007): Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 48: 1308–1317.

    Article  PubMed  CAS  Google Scholar 

  • Beydoun A (1999): Monotherapy trials with gabapentin for partial epilepsy. Epilepsia 40 (Suppl 6): S13–S16.

    Article  PubMed  CAS  Google Scholar 

  • Boyle J, Eriksson ME, Gribble L, Gouni R, Johnsen S, Coppini DV, Kerr D (2012): Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life. Diabetes Care 35: 2451–2458.

    Article  PubMed  CAS  Google Scholar 

  • Brodie MJ (2004): Pregabalin as adjunctive therapy for partial seizures. Epilepsia 45 Suppl 6: 19–27.

    Article  PubMed  CAS  Google Scholar 

  • Brodie MJ, Perucca E, Ryvlin P, Ben-Menachem E, Meencke HJ (2007): Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 68: 402–408.

    Article  PubMed  CAS  Google Scholar 

  • Costa J, Fareleira F, Ascenção R, Borges M, Sampaio C, Vaz-Carneiro A (2011): Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis. Epilepsia 52: 1280–1291.

    Article  PubMed  Google Scholar 

  • Devinsky O (2011): Sudden, unexpected death in epilepsy. N Engl J Med 365: 1801–1811.

    Article  PubMed  CAS  Google Scholar 

  • Dooley M, Plosker GL (2000): Levetiracetam. A review of its adjunctive use in the management of partial onset seizures. Drugs 60: 871–893.

    Article  PubMed  CAS  Google Scholar 

  • Eisenberg E, River Y, Shifrin A, Krivoy N (2007): Antiepileptic drugs in the treatment of neuropathic pain. Drugs 67: 1265–1289.

    Article  PubMed  CAS  Google Scholar 

  • European Medicines Agency (2004): Europäischer öffentlicher Beurteilungsbericht (EPAR) Lyrica. Scientific discussion. Internet: www.emea.europa.eu/humandocs/PDFs/EPAR/lyrica/084504en6.pdf

  • Finnerup NB, Sindrup SH, Jensen TS (2010): The evidence for pharmacological treatment of neuropathic pain. Pain 150: 573–581.

    Article  PubMed  Google Scholar 

  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ Jr, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught RE Jr, Sachdeo RC, Beydoun A, Glauser TA; American Academy of Neurology Therapeutics and Technology Assessment Subcommittee; American Academy of Neurology Quality Standards Subcommittee; American Epilepsy Society Quality Standards Subcommittee; American Epilepsy Society Therapeutics and Technology Assessment Subcommittee (2004): Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 45: 401–409.

    Google Scholar 

  • Gamble CL, Williamson PR, Marson AG (2006): Lamotrigine versus carbamazepine monotherapy for epilepsy. Cochrane Database Syst Rev 25(1):CD001031.

    Google Scholar 

  • Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Chadwick D, Guerreiro C, Kalviainen R, Mattson R, Perucca E, Tomson T (2006): ILAE Treatment Guidelines: Evidencebased analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 47: 1094–1120.

    Article  PubMed  Google Scholar 

  • Goa KL, Ross SR, Chrisp P (1993): Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 46: 152–176.

    Article  PubMed  CAS  Google Scholar 

  • Groß-Selbeck G (1995): Treatment of “benign” partial epilepsies of childhood, including atypical forms. Neuropediatrics 26: 45–50.

    Article  PubMed  Google Scholar 

  • Hitiris N, Brodie MJ (2006): Modern antiepileptic drugs: guidelines and beyond. Curr Opin Neurol 19: 175–180.

    PubMed  Google Scholar 

  • Holmes D (2012): NICE epilepsy guidance “may be detrimental to patient care”. Lancet 379: 399.

    Article  PubMed  Google Scholar 

  • Jette NJ, Marson AG, Kadir ZA, Hutton JL (2000): Topiramate for drug-resistant partial epilepsy. Cochrane Database Syst Rev 2: CD001417.

    Google Scholar 

  • Kassenärztliche Bundesvereinigung (2007): Wirkstoff AKTUELL. Pregabalin (Lyrica® Hartkapseln).Internet: www.kbv.de/publikationen/116.html

  • Koch MW, Polman SK (2009): Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD006453.

    Google Scholar 

  • Kwan P, Sander JW (2004): The natural history of epilepsy: an epidemiological view. J Neurol Neurosurg Psychiatry 75: 1376–1381.

    Article  PubMed  CAS  Google Scholar 

  • LaRoche SM, Helmers SL (2004): The new antiepileptic drugs: scientific review. JAMA 291: 605–614.

    Article  PubMed  CAS  Google Scholar 

  • Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (2004): The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. PNAS 101: 9861–9866.

    Article  PubMed  CAS  Google Scholar 

  • Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJL, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DS, Smith PEM, Tudor Smith C, Vanoli A, Williamson PR, on behalf of the SANAD Study group (2007a): The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet 369: 1000–1015.

    Google Scholar 

  • Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJL, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DS, Smith PEM, Tudor Smith C, Vanoli A, Williamson PR, on behalf of the SANAD Study group (2007b): The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalized and unclassifiable epilepsy: an unblinded randomized controlled trial. Lancet 369: 1016–1026.

    Google Scholar 

  • Mbizvo GK, Dixon P, Hutton JL, Marson AG (2012): Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane Review. Cochrane Database Syst Rev. 2012 Sep 12; 9: CD001901.

    Google Scholar 

  • McCorry D, Chadwick D, Marson A (2004): Current drug treatment of epilepsy in adults. Lancet Neurol 3: 729–735.

    Article  PubMed  CAS  Google Scholar 

  • Mølgaard-Nielsen D, Hviid A (2011): Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA 305: 1996–2002.

    Article  PubMed  Google Scholar 

  • Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA (1999): Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. Arch Intern Med 159: 1931–1937.

    Article  PubMed  CAS  Google Scholar 

  • National Institute for Health and Clinical Excellence (NICE) (2012): The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. January 2012, NICE clinical guideline 137. Internet: www.nice.org.uk/page.aspx?o=CG020NICEguideline

  • Nunes VD, Sawyer L, Neilson J, Sarri G, Cross JH (2013): Profile of lacosamide and its role in the long-term treatment of epilepsy: a perspective from the updated NICE guideline. Neuropsychiatr Dis Treat 9: 467–476.

    Article  PubMed  CAS  Google Scholar 

  • Perucca E, Yasothan U, Clincke G, Kirkpatrick P (2008): Lacosamide. Nat Rev Drug Discov 7: 973–974.

    Article  PubMed  CAS  Google Scholar 

  • Shorvon SD (2009): Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959–2009. Epilepsia 50 Suppl 3: 93–130.

    Article  PubMed  Google Scholar 

  • Weil S, Deppe C, Noachtar S (2010): Behandlung von Frauen mit Epilepsie. Dtsch Ärztebl 107: 787–793.

    Google Scholar 

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Schwabe, U. (2013). Antiepileptika. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2013. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37124-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-37124-0_13

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