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Nervenchirurgie pp 261–327Cite as

Nervenkompressionssyndrome

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Zusammenfassung

Nervenkompressionssyndrome sind für den Patienten erheblich beeinträchtigende und oft auch beruflich einschränkende Störungen. Durch einen operativen Eingriff sind sie jedoch mehr oder weniger folgenlos zu beheben. Zum Verständnis der Schädigungsmuster und damit auch zur Prognose gab es viele Untersuchungen und zum Teil divergierende pathogenetische Erklärungsmuster. Da menschliches Nervenmaterial nicht ausreichend zur Verfügung steht, beruhen die Erkenntnisse zur Pathogenese zumeist auf experimentellen Untersuchungen mit verschiedenen Tiermodellen. Man kann auch für den Menschen davon ausgehen, dass eine chronische Kompression im Frühstadium zu einer Schwann-Zell-Proliferation und -Apoptose führt. Hierdurch kommt es im Kompressionsbereich zu einer lokalen Demyelinisierung und Remyelinisierung. Zusätzlich erlaubt die Herabregulierung von Proteinen der Myelinscheide die Aussprossung von Axonen.

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Authors and Affiliations

  1. Abtsweg 13, 69198, Schriesheim, Deutschland

    Hans Assmus

  2. Abteilung für Neurosurgery, Universität Ulm, Ludwig-Heilmeyer-Str. 2, 89312, Günzburg, Deutschland

    Gregor Antoniadis

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  1. Hans Assmus
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Editors and Affiliations

  1. Universitätsklinik für Neurochirurgie, Evangelisches Krankenhaus - Carl von Ossietzky Universität, Oldenburg, Germany

    Thomas Kretschmer

  2. Neurochirurgische Klinik der Universität Ulm am Bezirkskrankenhaus Günzburg, Günzburg, Germany

    Gregor Antoniadis

  3. Schriesheim, Baden-Württemberg, Germany

    Hans Assmus

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Assmus, H., Antoniadis, G. (2014). Nervenkompressionssyndrome. In: Kretschmer, T., Antoniadis, G., Assmus, H. (eds) Nervenchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36895-0_7

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